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Literature summary for 2.7.2.3 extracted from

  • Boyle, H.A.; Fairbrother, W.J.; Williams, R.J.P.
    An NMR analysis of the binding of inhibitors to yeast phosphoglycerate kinase (1989), Eur. J. Biochem., 184, 535-543.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(p-Sulfophenylazo)-1,8-dihydroxy-3,6-naphthalene disulfonic acid competitive against MgATP2- and 3-phospho-D-glycerate Saccharomyces cerevisiae
Hexametaphosphate competitive against 3-phospho-D-glycerate and noncompetitive against MgATP2- Saccharomyces cerevisiae
hydroxyethylidene bisphosphonic acid competitive against MgATP2- and 3-phospho-D-glycerate Saccharomyces cerevisiae
Naphthalene-1,3,6-trisulfonic acid competitive against 3-phospho-D-glycerate and noncompetitive against MgATP2-, binding structure Saccharomyces cerevisiae
suramin competitive against MgATP2- and 3-phospho-D-glycerate Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
commercial product
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
Saccharomyces cerevisiae ADP + 1,3-diphosphoglycerate
-
r

Cofactor

Cofactor Comment Organism Structure
ADP
-
Saccharomyces cerevisiae
ATP true substrate is the magnesium complexes of ATP Saccharomyces cerevisiae
ATP required as phosphate donor Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
2-(p-Sulfophenylazo)-1,8-dihydroxy-3,6-naphthalene disulfonic acid pH 7.5, versus 3-phospho-D-glycerate Saccharomyces cerevisiae
0.13
-
suramin pH 7.5, versus MgATP2- Saccharomyces cerevisiae
0.15
-
2-(p-Sulfophenylazo)-1,8-dihydroxy-3,6-naphthalene disulfonic acid pH 7.5, versus MgATP2- Saccharomyces cerevisiae
0.16
-
suramin pH 7.5, versus 3-phospho-D-glycerate Saccharomyces cerevisiae
1.28
-
Hexametaphosphate pH 7.5, versus 3-phospho-D-glycerate Saccharomyces cerevisiae
5.5
-
Naphthalene-1,3,6-trisulfonic acid pH 7.5, versus 3-phospho-D-glycerate Saccharomyces cerevisiae
23
-
hydroxyethylidene bisphosphonic acid pH 7.5, versus MgATP2- Saccharomyces cerevisiae
25
-
hydroxyethylidene bisphosphonic acid pH 7.5, versus 3-phospho-D-glycerate Saccharomyces cerevisiae