Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a promising therapeutic target for the treatment of Chagas' disease | Trypanosoma cruzi |
pharmacology | the enzyme is a promising therapeutic target for the treatment of Chagas' disease | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6,9-diamino-2-ethoxyacridine lactate | - |
Trypanosoma cruzi | |
adenosine diphosphate (hydroxymethyl) pyrrolidinediol | - |
Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | the enzyme is localized in the nucleus independently of the presence of DNA damage or cell cycle stage | Trypanosoma cruzi | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ADP-D-ribose)n + H2O | Trypanosoma cruzi | - |
poly(ADP-D-ribose)n-1 + ADP-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | Q0PW90 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epimastigote | the enzyme is expressed in a life stage-dependant manner | Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ADP-D-ribose)n + H2O | - |
Trypanosoma cruzi | poly(ADP-D-ribose)n-1 + ADP-ribose | - |
? |
General Information | Comment | Organism |
---|---|---|
evolution | conservation of key residues involved in the catalytic process | Trypanosoma cruzi |
malfunction | lack of poly(ADPribose) glycohydrolase activity in Vero and A549 host cells, achieved by chemical inhibition or iRNA, produces the reduction of the percentage of infected cells as well as the number of amastigotes per cell and trypomastigotes released, leading to a nearly complete abrogation of the infection process | Trypanosoma cruzi |
physiological function | poly(ADP-ribose) glycohydrolase (PARG) represents the main poly(ADP-D-ribose) hydrolyzing activity in the cell to ADP-ribose units. The enzyme is crucial for Trypanosoma cruzi infection cycle in the human host cell. Both, Trypanosoma cruzi and the human host, poly(ADP-ribose) glycohydrolase activities are important players in the life cycle of Trypanosoma cruzi | Trypanosoma cruzi |