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Literature summary for 3.2.1.143 extracted from

  • Vilchez Larrea, S.C.; Schlesinger, M.; Kevorkian, M.L.; Flawia, M.M.; Alonso, G.D.; Fernandez Villamil, S.H.
    Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle (2013), PLoS ONE, 8, e67356.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme is a promising therapeutic target for the treatment of Chagas' disease Trypanosoma cruzi
pharmacology the enzyme is a promising therapeutic target for the treatment of Chagas' disease Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
6,9-diamino-2-ethoxyacridine lactate
-
Trypanosoma cruzi
adenosine diphosphate (hydroxymethyl) pyrrolidinediol
-
Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the enzyme is localized in the nucleus independently of the presence of DNA damage or cell cycle stage Trypanosoma cruzi 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poly(ADP-D-ribose)n + H2O Trypanosoma cruzi
-
poly(ADP-D-ribose)n-1 + ADP-ribose
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q0PW90
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote the enzyme is expressed in a life stage-dependant manner Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(ADP-D-ribose)n + H2O
-
Trypanosoma cruzi poly(ADP-D-ribose)n-1 + ADP-ribose
-
?

General Information

General Information Comment Organism
evolution conservation of key residues involved in the catalytic process Trypanosoma cruzi
malfunction lack of poly(ADPribose) glycohydrolase activity in Vero and A549 host cells, achieved by chemical inhibition or iRNA, produces the reduction of the percentage of infected cells as well as the number of amastigotes per cell and trypomastigotes released, leading to a nearly complete abrogation of the infection process Trypanosoma cruzi
physiological function poly(ADP-ribose) glycohydrolase (PARG) represents the main poly(ADP-D-ribose) hydrolyzing activity in the cell to ADP-ribose units. The enzyme is crucial for Trypanosoma cruzi infection cycle in the human host cell. Both, Trypanosoma cruzi and the human host, poly(ADP-ribose) glycohydrolase activities are important players in the life cycle of Trypanosoma cruzi Trypanosoma cruzi