3.5.1.4: amidase

This is an abbreviated version!
For detailed information about amidase, go to the full flat file.

Reaction

Synonyms

4-guanidinobutyramide hydrolase, A-amidase, acetamidase, acid transferase, acylamidase, acylase, AMI1, amidase, amidase 1, amide hydrolase, amide transferase, amidohydrolase, AmiE, Ana, anandamide hydrolase, AtFAAH, Azl13, C-amidase, deaminase, ester transferase, FAAH, FAAH-1, FAAH-2, fatty acid amide hydrolase, fatty acid amide hydrolase 1, fatty acylamidase, half-amidase, indole-3-acetamide amidohydrolase, K1, mHG, Mhpg, More, murein peptide amidase A, mycothiol-S-conjugate amidase, N-acetylaminohydrolase, N-acylethanolamine acid amidase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, NAE-hydrolyzing acid amidase, PamH, PYCH_10400, R-stereospecific amidase, RhAmidase, signature amidase, SsAH, SSAM, SSO2122, tissue kallikrein, Wide spectrum amidase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.4 amidase

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Results	in table
18	Activating Compound
23224	AA Sequence
38	Application
1	CAS Registry Number
37	Cloned(Commentary)
9	Crystallization (Commentary)
1520	Disease/ Diagnostics
15	General Information
1	General Stability
122	IC50 Value
650	Inhibitors
80	kcat/KM [mM/s]
272	Ki Value [mM]
192	KM Value [mM]
18	Localization
24	Metals/Ions
97	Molecular Weight [Da]
81	Natural Substrates/ Products (Substrates)
17	Organic Solvent Stability
455	Organism
2	Oxidation Stability
18	Pathway
52	PDB ID
55	pH Optimum
26	pH Range
10	pH Stability
5	pI Value
55	Protein Variants
58	Purification (Commentary)
9	Reaction
56	Reaction Type
194	Reference
2	Renatured (Commentary)
70	Source Tissue
135	Specific Activity [micromol/min/mg]
10	Storage Stability
572	Substrates and Products (Substrate)
77	Subunits
103	Synonyms
1	Systematic Name
49	Temperature Optimum [°C]
19	Temperature Range [°C]
40	Temperature Stability [°C]
124	Turnover Number [1/s]

Organism

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Organism on EC 3.5.1.4 - amidase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Achromobacter xylosoxidans

gene ana

668663

Q5YFS2

SwissProt

brenda

Aeribacillus pallidus

3 entries

Aeribacillus pallidus BTP-5x MTCC 9225

isolated from thermal springs of Tatapani (Himachal Pradesh)

733127

-

-

brenda

Aeribacillus pallidus RAPc8

2 entries

Agrobacterium tumefaciens

Crown gall

209117

-

-

brenda

Alcaligenes sp.

2 entries

Alcaligenes sp. DSM 11172

strain FB188, or Bordetella sp.

655874

Q70I53

SwissProt

brenda

Alcaligenes sp. MTCC 10674

isolated as a nitrile degrading bacterium from the soil

734464

-

-

brenda

Arabidopsis thaliana

-

686659, 689668, 689737

-

-

brenda

Arthrobacter sp.

-

209107

-

-

brenda

Blastobacter sp.

-

209109

-

-

brenda

Brevibacterium epidermidis

-

687348

-

-

brenda

Brevibacterium epidermidis ZJB-07021

-

687348

-

-

brenda

Brevibacterium sp.

2 entries

Brevibacterium sp. R312

-

209108, 209125, 209126

-

-

brenda

Brevundimonas diminuta

-

663744

-

-

brenda

Brevundimonas diminuta AM10-C-1

-

663744

-

-

brenda

Burkholderia cepacia

hospital isolate

665225

-

-

brenda

Burkholderia cepacia C

hospital isolate

665225

-

-

brenda

Burkholderia sp.

2 entries

Burkholderia sp. DR.Y27

2 entries

Citrus sinensis

-

655071

-

-

brenda

Cucurbita maxima

Duch, tissues of aseptically grown squash

209117

-

-

brenda

Cyberlindnera jadinii

-

655819

-

-

brenda

Delftia acidovorans

2 entries

Delftia acidovorans AE1

-

209120, 209121

-

-

brenda

Delftia acidovorans KPO-2771-4

-

209116

-

-

brenda

Delftia tsuruhatensis

-

684599

-

-

brenda

Delftia tsuruhatensis MA52

-

684599

-

-

brenda

Dictyostelium discoideum

-

209110

-

-

brenda

Escherichia coli

3 entries

Escherichia coli JM109

harboring pALJ30 and pALJ20

209113, 209116, 209131, 209132

-

-

brenda

Escherichia coli RB791

and strain HB101

209130

-

-

brenda

Geobacillus subterraneus

isolated from Manikaran thermal spring (Himachal Pradesh, India)

733808

-

-

brenda

Geobacillus subterraneus RL-2a

isolated from Manikaran thermal spring (Himachal Pradesh, India)

733808

-

-

brenda

Helicobacter pylori

-

209143

-

-

brenda

Homo sapiens

6 entries

Human immunodeficiency virus 1

i.e. HIV1

668250

-

-

brenda

Klebsiella oxytoca

-

670923

-

-

brenda

Klebsiella pneumoniae

-

209115

-

-

brenda

Meleagris gallopavo

-

690119

-

-

brenda

Methylophilus methylotrophus

wild-type is strain MM6, mutant strains are MM8 and MM15

209107

-

-

brenda

Microbacterium hydrocarbonoxydans

2 entries

Microbacterium imperiale

-

686460

-

-

brenda

Microbacterium imperiale CBS 498-74

-

686460

-

-

brenda

Mus musculus

2 entries

Mycobacterium avium

-

655819

-

-

brenda

Mycobacterium tuberculosis

-

685580

-

-

brenda

Nesterenkonia sp.

isolated from mineral soil collected from the Miers Valley, McMurdo region, eastern Antarctica

718637

C6K3Z5

UniProt

brenda

Nesterenkonia sp. AN1

isolated from mineral soil collected from the Miers Valley, McMurdo region, eastern Antarctica

718637

C6K3Z5

UniProt

brenda

Ochrobactrum sp.

-

684599

-

-

brenda

Ochrobactrum sp. T12

-

684599

-

-

brenda

Paracoccus sp.

gene pamH

718672

G9FKH7

UniProt

brenda

Porphyromonas gingivalis

and strain H66

209112

-

-

brenda

Porphyromonas gingivalis OMGS 100

and strain H66

209112

-

-

brenda

Pseudomonas aeruginosa

13 entries

Pseudomonas aeruginosa 8602

2 entries

Pseudomonas aeruginosa AI3

2 entries

Pseudomonas aeruginosa PAC 111 (C11)

-

209118

-

-

brenda

Pseudomonas aeruginosa PAC 142 (L10R)

-

209118, 209129

-

-

brenda

Pseudomonas aeruginosa PAC142

PAC142

663911

-

-

brenda

Pseudomonas chlororaphis

-

209105

-

-

brenda

Pseudomonas chlororaphis B23

-

209105

-

-

brenda

Pseudomonas putida

3 entries

Pseudomonas putida 5B

-

679461

-

-

brenda

Pseudomonas putida BR-1

isolated from rhizosphere of cyanogenic plant Circium vulgare

733617

-

-

brenda

Pseudomonas putida PP3

and strain PPW3

209127

-

-

brenda

Pseudomonas sp.

-

209106, 684599

-

-

brenda

Pseudomonas sp. W13

-

684599

-

-

brenda

Pseudonocardia thermophila

thermophilic actinomycete, DSMZ 43832

667278

-

-

brenda

Pyrococcus yayanosii

-

724942

F8AEP0

UniProt

brenda

Pyrococcus yayanosii CH1

-

724942

F8AEP0

UniProt

brenda

Raoultella terrigena

DSM 9174

660534

-

-

brenda

Rattus norvegicus

8 entries

Rhodococcus erythropolis

7 entries

Rhodococcus erythropolis MP50

-

209114

-

-

brenda

Rhodococcus erythropolis NCIMB11540

sequence identical to the sequenced enzyme fragment from strain NCIMB11540; NCIMB11540

664412

P22984

UniProt

brenda

Rhodococcus erythropolis No. 7

-

699491

B4XEY3

UniProt

brenda

Rhodococcus erythropolis R4

-

753001

-

-

brenda

Rhodococcus rhodochrous

-

209113, 209132, 666090

-

-

brenda

Rhodococcus rhodochrous IFO 15564

-

666090

-

-

brenda

Rhodococcus rhodochrous J1

-

209113, 209132

-

-

brenda

Rhodococcus sp.

-

209106, 209108, 655819, 671557, 684599

-

-

brenda

Rhodococcus sp. AA21

-

684599

-

-

brenda

Rhodococcus sp. N-771

-

711308

Q7DKE4

UniProt

brenda

Rhodococcus sp. R312

-

655819

-

-

brenda

Rhodococcus sp. S13-4

-

671557

-

-

brenda

Saccharolobus solfataricus

4 entries

Saccharolobus solfataricus MT4

2 entries

Saccharolobus solfataricus P2

-

724144, 724954

P95896

SwissProt

brenda

Streptococcus phage EJ-1

bacteriophage isolated from Pneumococcus sp., strain 101/87

657289

-

-

brenda

Streptococcus pneumoniae

wild-type strain R6

209130

-

-

brenda

Streptomyces sp.

gene azl13

733190

A0A088BHP3

UniProt

brenda

Streptomyces sp. 211726

gene azl13

733190

A0A088BHP3

UniProt

brenda

Sulfurisphaera tokodaii

gene ST0478

670782

-

-

brenda

Sulfurisphaera tokodaii 7

gene ST0478

670782

-

-

brenda

Sus scrofa

2 entries

Torula cremoris

-

655819

-

-

brenda

Aeribacillus pallidus

-

684137, 684607

-

-

brenda

Aeribacillus pallidus

isolated from thermal springs of Tatapani (Himachal Pradesh)

733127

-

-

brenda

Aeribacillus pallidus

recombinantly expressed in Escherichia coli

684206

-

-

brenda

Aeribacillus pallidus RAPc8

-

684137, 684607

-

-

brenda

Aeribacillus pallidus RAPc8

recombinantly expressed in Escherichia coli

684206

-

-

brenda

Alcaligenes sp.

isolated as a nitrile degrading bacterium from the soil

734464

-

-

brenda

Alcaligenes sp.

strain FB188, or Bordetella sp.

655874

Q70I53

SwissProt

brenda

Brevibacterium sp.

-

209106, 209108, 209125, 209126, 209128

-

-

brenda

Brevibacterium sp.

mutant strains A4 and 19

209124, 209126

-

-

brenda

Burkholderia sp.

an acrylamide-degrading bacterium isolated from the grounds of a palm estate in Serdang, Selangor

718531

-

-

brenda

Burkholderia sp.

previously isolated from the grounds of a palm estate in Serdang, Selangor

718531

-

-

brenda

Burkholderia sp. DR.Y27

an acrylamide-degrading bacterium isolated from the grounds of a palm estate in Serdang, Selangor

718531

-

-

brenda

Burkholderia sp. DR.Y27

previously isolated from the grounds of a palm estate in Serdang, Selangor

718531

-

-

brenda

Delftia acidovorans

-

209116, 209120, 209121

-

-

brenda

Delftia acidovorans

DSM 6351

659837

-

-

brenda

Escherichia coli

-

655866

-

-

brenda

Escherichia coli

and strain HB101

209130

-

-

brenda

Escherichia coli

harboring pALJ30 and pALJ20

209113, 209116, 209131, 209132

-

-

brenda

Homo sapiens

-

685574, 685597

-

-

brenda

Homo sapiens

-

686040

O00519, Q02083

SwissProt

brenda

Homo sapiens

-

688249, 688512

-

-

brenda

Homo sapiens

from COS-7 cells transfected with human FAAH-1

687528

O00519, Q6GMR7

SwissProt

brenda

Homo sapiens

healthy male individuals

669651

-

-

brenda

Homo sapiens

recombinantly expressed in COS-7 cells

688296

-

-

brenda

Microbacterium hydrocarbonoxydans

additionally acts as as (+)-gamma-lactamase

735550

E3SVS0

UniProt

brenda

Microbacterium hydrocarbonoxydans

additionally acts as isochorismatase, EC 3.3.2.1 and as (+)-gamma-lactamase

735550

A0A077AY47

UniProt

brenda

Mus musculus

-

686040

O08914, Q9D7V9

SwissProt

brenda

Mus musculus

-

688513

-

-

brenda

Pseudomonas aeruginosa

-

209106, 209107, 209118, 209119, 209122, 209129, 654182

-

-

brenda

Pseudomonas aeruginosa

-

654500

P11436

SwissProt

brenda

Pseudomonas aeruginosa

-

680785, 681854, 681860, 688472

-

-

brenda

Pseudomonas aeruginosa

and strains AIU1N and OUCH4

209123

-

-

brenda

Pseudomonas aeruginosa

and the mutant strains AIU1N and OUCH4

209123

-

-

brenda

Pseudomonas aeruginosa

C166S and C166A mutants

209131

-

-

brenda

Pseudomonas aeruginosa

gene amiE

719144

-

-

brenda

Pseudomonas aeruginosa

gene amiE, inducible enzyme

677370, 680785

-

-

brenda

Pseudomonas aeruginosa

mutant strain KLAM59

209131, 666303

-

-

brenda

Pseudomonas aeruginosa

mutant strain Ph1

666303

-

-

brenda

Pseudomonas aeruginosa

mutant strains B6, AI3, AIU1N, OUCH and L10

664239

-

-

brenda

Pseudomonas aeruginosa

PAC142

663911

-

-

brenda

Pseudomonas aeruginosa

PAU3 and PAU5

209127

-

-

brenda

Pseudomonas aeruginosa 8602

-

654182, 681860

-

-

brenda

Pseudomonas aeruginosa 8602

gene amiE

719144

-

-

brenda

Pseudomonas aeruginosa AI3

and strains AIU1N and OUCH4

209123

-

-

brenda

Pseudomonas aeruginosa AI3

and the mutant strains AIU1N and OUCH4

209123

-

-

brenda

Pseudomonas putida

-

679461

-

-

brenda

Pseudomonas putida

and strain PPW3

209127

-

-

brenda

Pseudomonas putida

isolated from rhizosphere of cyanogenic plant Circium vulgare

733617

-

-

brenda

Rattus norvegicus

-

681315, 685574

-

-

brenda

Rattus norvegicus

-

686040

P97612, Q5KTC7

SwissProt

brenda

Rattus norvegicus

-

686058, 687535, 690174, 720200, 733491

-

-

brenda

Rattus norvegicus

adult Sprague-Dawley rats

664468

-

-

brenda

Rattus norvegicus

adults

655133

-

-

brenda

Rattus norvegicus

expressed in Escherichia coli

688249

-

-

brenda

Rattus norvegicus

recombinantly expressed in Escherichia coli

688296

-

-

brenda

Rattus norvegicus

Sprague-Dawley rats

663883, 664469

-

-

brenda

Rhodococcus erythropolis

-

209114

-

-

brenda

Rhodococcus erythropolis

-

699491

B4XEY3

UniProt

brenda

Rhodococcus erythropolis

-

699632

P22984

UniProt

brenda

Rhodococcus erythropolis

-

712726, 753001

-

-

brenda

Rhodococcus erythropolis

gene ami

712780

-

-

brenda

Rhodococcus erythropolis

sequence identical to the sequenced enzyme fragment from strain NCIMB11540; NCIMB11540

664412

P22984

UniProt

brenda

Rhodococcus erythropolis

strain MTCC 1526, Rhodococcus erythropolis strain MTCC 1548 and Rhodococcus sp. strains MTCC 2574, 2678, 2683, 2794 and 3951 produce also amidase

699367

-

-

brenda

Saccharolobus solfataricus

-

694992, 711039

-

-

brenda

Saccharolobus solfataricus

-

719432, 724144, 724954

P95896

SwissProt

brenda

Saccharolobus solfataricus

gene SsAH

694992

-

-

brenda

Saccharolobus solfataricus

MT4 strain

654122

-

-

brenda

Saccharolobus solfataricus MT4

-

719432

P95896

SwissProt

brenda

Saccharolobus solfataricus MT4

MT4 strain

654122

-

-

brenda

Sus scrofa

-

655819

-

-

brenda

Sus scrofa

-

686040

Q9TUI8

SwissProt

brenda