Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3'-(aminocarbonyl)biphenyl-3-yl cyclohexylcarbamate | - |
Homo sapiens | |
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | - |
Homo sapiens | |
4-(benzyloxy)phenyl butylcarbamate | - |
Homo sapiens | |
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | FAAH-1 shows predominantly cytoplasmic orientation | Homo sapiens | 16020 | - |
membrane | FAAH-2 is luminally orientated in the membrane | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | FAAH-1 plays a primary role in regulating endocannabinoid signaling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00519 | from COS-7 cells transfected with human FAAH-1 | - |
Homo sapiens | Q6GMR7 | from COS-7 cells transfected with human FAAH-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | FAAH-1 is highly expressed | Homo sapiens | - |
heart | FAAH-2 | Homo sapiens | - |
kidney | FAAH-1 | Homo sapiens | - |
kidney | FAAH-2 | Homo sapiens | - |
liver | FAAH-1 | Homo sapiens | - |
liver | FAAH-2 | Homo sapiens | - |
lung | FAAH-1 | Homo sapiens | - |
lung | FAAH-2 | Homo sapiens | - |
additional information | no FAAH-1 activity is detected in heart | Homo sapiens | - |
prostate | FAAH-1 | Homo sapiens | - |
prostate | FAAH-2 | Homo sapiens | - |
small intestine | FAAH-1 is highly expressed | Homo sapiens | - |
testis | FAAH-1 is highly expressed | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | FAAH-1 | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
anandamide + H2O | FAAH-2 | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
additional information | FAAH-1 plays a primary role in regulating endocannabinoid signaling | Homo sapiens | ? | - |
? | |
additional information | no FAAH-2 activity is detected with N-oleoyl taurine | Homo sapiens | ? | - |
? | |
N-oleoyl ethanolamine + H2O | FAAH-1 | Homo sapiens | oleic acid + ethanolamine | - |
? | |
N-oleoyl ethanolamine + H2O | FAAH-2 | Homo sapiens | oleic acid + ethanolamine | - |
? | |
N-oleoyl taurine + H2O | FAAH-1 | Homo sapiens | oleic acid + taurine | - |
? | |
N-palmitolyl ethanolamine + H2O | FAAH-1 | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
N-palmitolyl ethanolamine + H2O | FAAH-2 | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
oleamide + H2O | FAAH-1 | Homo sapiens | oleic acid + NH3 | - |
? | |
oleamide + H2O | FAAH-2 | Homo sapiens | oleic acid + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAAH-1 | - |
Homo sapiens |
FAAH-2 | - |
Homo sapiens |
fatty acid amide hydrolase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000038 | - |
- |
Homo sapiens | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | |
0.000001 | - |
- |
Homo sapiens | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | |
0.0000134 | - |
- |
Homo sapiens | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | |
0.000206 | - |
- |
Homo sapiens | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | |
0.000283 | - |
- |
Homo sapiens | 4-(benzyloxy)phenyl butylcarbamate | |
0.00136 | - |
- |
Homo sapiens | 4-(benzyloxy)phenyl butylcarbamate |