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3.5.1.4: amidase

This is an abbreviated version!
For detailed information about amidase, go to the full flat file.

Word Map on EC 3.5.1.4

Reaction

a monocarboxylic acid amide
+
H2O
=
a monocarboxylate
 +
NH3

Synonyms

4-guanidinobutyramide hydrolase, A-amidase, acetamidase, acid transferase, acylamidase, acylase, AMI1, amidase, amidase 1, amide hydrolase, amide transferase, amidohydrolase, AmiE, Ana, anandamide hydrolase, AtFAAH, Azl13, C-amidase, deaminase, ester transferase, FAAH, FAAH-1, FAAH-2, fatty acid amide hydrolase, fatty acid amide hydrolase 1, fatty acylamidase, half-amidase, indole-3-acetamide amidohydrolase, K1, mHG, Mhpg, More, murein peptide amidase A, mycothiol-S-conjugate amidase, N-acetylaminohydrolase, N-acylethanolamine acid amidase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, NAE-hydrolyzing acid amidase, PamH, PYCH_10400, R-stereospecific amidase, RhAmidase, signature amidase, SsAH, SSAM, SSO2122, tissue kallikrein, Wide spectrum amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.4 amidase

IC50 Value

IC50 Value on EC 3.5.1.4 - amidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.09
(+/-)-(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
Rattus norvegicus
-
-
0.098
(+/-)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.012
(+/-)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.0082
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
Rattus norvegicus
-
-
0.011
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate
Rattus norvegicus
-
-
0.01
(+/-)-oxiran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
Rattus norvegicus
-
-
0.0016
(+/-)-oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
-
0.061
(+/-)-oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
Rattus norvegicus
-
-
0.035
(+/-)-oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
-
0.051
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.01
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z)-hexadec-9-enoate
Rattus norvegicus
-
-
0.029
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
Rattus norvegicus
-
-
0.0075
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
Rattus norvegicus
-
-
0.019
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
Rattus norvegicus
-
-
0.043
(+/-)-tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
Rattus norvegicus
-
-
0.018
(+/-)-tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
Rattus norvegicus
-
-
0.032
(+/-)-tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
Rattus norvegicus
-
-
0.053
(+/-)-tetrahydro-2H-pyran-2-ylmethyl benzoate
Rattus norvegicus
-
-
0.0049
(2R,3R)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
0.1
(2R,3S)-2-methyl-4-oxo-3-oxetanylcarbamic acid benzyl ester
0.08
(2R,3S)-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
0.000127
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid 5-phenylpentyl ester
0.001
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid benzyl ester
0.00022
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
0.00019
(2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
0.01
(5Z,8Z,11Z,14Z)-eicosantetraenoic acid 3-thienyl methyl ester
Rattus norvegicus
-
i.e. CAY-10402, IC50: 0.010 mM, 37% inhibition at 0.1 mM
0.0005
(R)-(2-oxo-3-oxetanyl)carbamic acid tert-butyl ester
0.0492
(R)-1-methyl-3-(2-oxo-3-oxetanyl)urea
0.0007
(R)-2-oxo-3-oxetanylcarbamic acid benzyl ester
0.1
(R,S)-2-oxocyclobutylcarbamic acid benzyl ester
0.00058
(S)-(2-oxo-3-oxetanyl)carbamic acid tert-butyl ester
0.015
(S)-1-methyl-3-(2-oxo-3-oxetanyl)urea
0.00296
(S)-2-oxo-3-oxetanylcarbamic acid benzyl ester
0.091
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.0057
1-(1,3-oxazol-2-yl)-4-piperidin-4-ylbutan-1-one
Homo sapiens
-
-
0.000022
1-(1,3-oxazol-2-yl)-4-[1-(3-phenylpropanoyl)piperidin-4-yl]butan-1-one
Homo sapiens
-
-
0.0005
1-(1,3-oxazol-2-yl)-4-[1-(phenylacetyl)piperidin-4-yl]butan-1-one
Homo sapiens
-
-
0.0000025
1-(1,3-oxazol-2-yl)-4-[1-(phenylsulfonyl)piperidin-4-yl]butan-1-one
Homo sapiens
-
-
0.000006
1-(1,3-oxazol-2-yl)-4-[1-[(2-phenylethyl)sulfonyl]piperidin-4-yl]butan-1-one
Homo sapiens
-
-
0.0062
1-arachidonoylglycerol
Rattus norvegicus
-
IC50: 0.0062 mM
0.018
1-myristin
Rattus norvegicus
-
IC50: 0.018 mM, complete inhibition is possible
0.008
1-palmitin
Rattus norvegicus
-
IC50: 0.0080 mM, complete inhibition is possible
0.01
2,3-dihydroxypropyl (11Z)-icos-11-enoate
Rattus norvegicus
-
i.e. O-4066, IC50: 0.010 mM, complete inhibition is possible
0.0057
2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate
Rattus norvegicus
-
i.e. O-3907, IC50: 0.0057 mM, complete inhibition is possible
0.011
2,3-dihydroxypropyl (5Z)-icos-5-enoate
Rattus norvegicus
-
i.e. O-3908, IC50: 0.011 mM, 84% inhibition is possible
0.0024
2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate
Rattus norvegicus
-
i.e. O-3973, IC50: 0.0024, 95% inhibition is possible
0.0076
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
Rattus norvegicus
-
i.e. O-3832, IC50: 0.0076 mM, complete inhibition is possible
0.0051
2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate
Rattus norvegicus
-
i.e. O-4081, IC50: 0.0051 mM, 90% inhibition is possible
0.014
2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate
Rattus norvegicus
-
i.e. O-3872, IC50: 0.014, complete inhibition is possible
0.023
2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate
Rattus norvegicus
-
i.e. 3846, IC50: 0.023, complete inhibition is possible
0.021
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.000002
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
Rattus norvegicus
-
-
0.00000038 - 0.000001
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
0.000077
4-(1-benzoylpiperidin-4-yl)-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000315
4-(1-benzylpiperidin-4-yl)-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000283 - 0.00136
4-(benzyloxy)phenyl butylcarbamate
0.000315
4-[1-(2-bromobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00026
4-[1-(2-chlorobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.004
4-[1-(2-methoxybenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.0012
4-[1-(2-methylbenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00009
4-[1-(3,3-dimethylbutanoyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00001
4-[1-(3-bromobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00006
4-[1-(3-chlorobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000003
4-[1-(3-cyclohexylpropanoyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000034
4-[1-(3-methoxybenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00009
4-[1-(3-methylbenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000045
4-[1-(4-bromobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000066
4-[1-(4-chlorobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00013
4-[1-(4-methoxybenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.0004
4-[1-(4-methylbenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.0006
4-[1-(benzylsulfonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.0001
4-[1-(cyclohexylacetyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000045
4-[1-(cyclohexylcarbonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00025
4-[1-(cyclopropylcarbonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.00014
4-[1-(isopropylsulfonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000005
4-[1-[3-(1-methylethoxy)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000001
4-[1-[3-(1-methylethyl)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.000014
4-[1-[4-(1-methylethoxy)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.0000036
4-[1-[4-(1-methylethyl)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
Homo sapiens
-
-
0.0000134 - 0.000206
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
0.033
alpha-methyl-1-arachidonoylglycerol
Rattus norvegicus
-
IC50: 0.033 mM, complete inhibition at 0.1 mM
0.058
arachidonic acid
Rattus norvegicus
-
IC50: 0.058 mM, complete inhibition at 0.1 mM
0.0049
arachidonoyl glycine
Rattus norvegicus
-
IC50: 0.0049 mM, complete inhibition at 0.1 mM
0.078
arachidonoyl serinol
Rattus norvegicus
-
IC50: 0.078 mM, complete inhibition at 0.1 mM
0.000004
benzyl 4-[4-(1,3-oxazol-2-yl)-4-oxobutyl]piperidine-1-carboxylate
Homo sapiens
-
-
0.0000005
CAY10400
Rattus norvegicus
-
-
0.1
cyclobutylcarbamic acid benzyl ester
0.000004
isopropyl 4-[4-(1,3-oxazol-2-yl)-4-oxobutyl]piperidine-1-carboxylate
Homo sapiens
-
-
0.0026
N-(4-hydroxy-2-methylphenyl)arachidonylamide
Rattus norvegicus
-
i.e. VDM11, an anandamide uptake inhibitor, IC50 is 0.0026 mM, inhibitory potency depends upon the concentration of bovine serum albumin
0.0021
N-(4-hydroxyphenyl)arachidonylamide
Rattus norvegicus
-
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM
0.000115
N-[(3S)-2-oxooxetan-3-yl]biphenyl-4-carboxamide
0.1
N-[(benzyloxy)carbonyl]-D-serine
0.1
N-[(benzyloxy)carbonyl]-L-serine
0.003
noladin ether
Rattus norvegicus
-
IC50: 0.003 mM, complete inhibition at 0.1 mM
0.0075
pentadecylamine
Rattus norvegicus
-
pH 5.0, 37°C
0.000002
tert-butyl 4-[4-(1,3-oxazol-2-yl)-4-oxobutyl]piperidine-1-carboxylate
Homo sapiens
-
-
0.0053
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Rattus norvegicus
-
-
0.0118
tridecyl 2-aminoacetate
Rattus norvegicus
-
pH 5.0, 37°C
0.05
UCM707
Rattus norvegicus
-
-
0.000002
URB597
Rattus norvegicus
-
-
0.005
VDM11
Rattus norvegicus
-
-