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3.5.1.4: amidase

This is an abbreviated version!
For detailed information about amidase, go to the full flat file.

Word Map on EC 3.5.1.4

Reaction

a monocarboxylic acid amide
+
H2O
=
a monocarboxylate
+
NH3

Synonyms

4-guanidinobutyramide hydrolase, A-amidase, acetamidase, acid transferase, acylamidase, acylase, AMI1, amidase, amidase 1, amide hydrolase, amide transferase, amidohydrolase, AmiE, Ana, anandamide hydrolase, AtFAAH, Azl13, C-amidase, deaminase, ester transferase, FAAH, FAAH-1, FAAH-2, fatty acid amide hydrolase, fatty acid amide hydrolase 1, fatty acylamidase, half-amidase, indole-3-acetamide amidohydrolase, K1, mHG, Mhpg, More, murein peptide amidase A, mycothiol-S-conjugate amidase, N-acetylaminohydrolase, N-acylethanolamine acid amidase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, NAE-hydrolyzing acid amidase, PamH, PYCH_10400, R-stereospecific amidase, RhAmidase, signature amidase, SsAH, SSAM, SSO2122, tissue kallikrein, Wide spectrum amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.4 amidase

Natural Substrates Products

Natural Substrates Products on EC 3.5.1.4 - amidase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-(+)-2-chloropropionamide + H2O
(+)-2-chloropropionic acid + NH3
show the reaction diagram
(S)-(-)-2-chloropropionamide + H2O
(-)-2-chloropropionic acid + NH3
show the reaction diagram
1-naphthaleneacetamide + H2O
1-naphthaleneacetic acid + NH3
show the reaction diagram
-
-
-
?
2 indole-3-acetonitrile + 3 H2O
indole-3-acetamide + indole-3-acetic acid + NH3
show the reaction diagram
-
-
-
?
2-arylpropionic amide + H2O
(S)-2-arylpropionic acid + NH3
show the reaction diagram
2-chloropropionamide + H2O
2-chloropropionate + NH3
show the reaction diagram
2-nitroacetanilide
2-nitrophenylamine + acetate
show the reaction diagram
3,3,3-trifluoro-2-hydroxy-2-methylpropanamide + H2O
3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid + NH3
show the reaction diagram
-
-
-
-
?
3-hydroxymyristoyl lipid A + H2O
?
show the reaction diagram
-
3-hydroxymyristoyl group linked to the proximal glucosamine residue of de-O-acylated lipid A, hydolysis by isozyme FAAI
-
-
?
4-guanidinobutyramide + H2O
?
show the reaction diagram
probably the natural substrate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
acetamide + H2O
acetic acid + NH3
show the reaction diagram
-
-
-
?
acetanilide + H2O
acetate + aniline
show the reaction diagram
acetohydrazide + H2O
hydrazine + acetate
show the reaction diagram
-
-
-
?
acetohydroxamate + H2O
hydroxylamine + acetate
show the reaction diagram
-
-
-
?
acrylamide + H2O
acrylic acid + NH3
show the reaction diagram
-
-
-
?
acylamide + H2O
carboxylic acid + NH3
show the reaction diagram
-
-
-
?
anandamide + H2O
?
show the reaction diagram
anandamide + H2O
arachidonic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
benzamide
benzoic acid + NH3
show the reaction diagram
Blastobacter sp.
-
-
-
?
benzamide + H2O
benzoic acid + NH3
show the reaction diagram
butyramide + H2O
n-butyrate + NH3
show the reaction diagram
-
-
-
?
carboxylic acid + hydroxylamine
N-hydroxy-carboxylic acid amide + H2O
show the reaction diagram
carboxylic acid amide + H2O
carboxylic acid + NH3
show the reaction diagram
carboxylic acid amide + hydroxylamine
N-hydroxy-carboxylic acid amide + NH3
show the reaction diagram
carboxylic acid ester + hydroxylamine
N-hydroxy-carboxylic acid amide + alcohol
show the reaction diagram
DL-lactamide + H2O
DL-lactate + NH3
show the reaction diagram
ethyl acetate + H2O
ethanol + acetate
show the reaction diagram
-
-
-
?
ethyl acrylate + H2O
acrylate + ethanol
show the reaction diagram
-
-
-
?
ethyl propionate + H2O
ethanol + propionate
show the reaction diagram
-
-
-
?
glutaramic acid + H2O
glutaric acid + NH3
show the reaction diagram
Blastobacter sp.
-
-
-
?
hydroxylamine + acylamide
acylhydroxamate + NH3
show the reaction diagram
-
acyltransferase activity
-
?
indole-3-acetamide + H2O
indole-3-acetic acid + NH3
show the reaction diagram
isobutyramide + H2O
isobutyrate + NH3
show the reaction diagram
-
-
-
?
ketoprofen amide
2-(3-benzoylphenyl)propionic acid + NH3
show the reaction diagram
monoamidated dicarboxylate + H2O
dicarboxylate + ammonia
show the reaction diagram
Blastobacter sp.
-
-
-
?
N-methylacetamide + H2O
methylamine + acetate
show the reaction diagram
-
-
-
?
N-methylpropionamide + H2O
methylamine + propionate
show the reaction diagram
-
-
-
?
phenetidine + acetate
phenacetin + H2O
show the reaction diagram
phenylacetamide
phenylacetic acid + NH3
show the reaction diagram
pivalamide + H2O
pivalate + NH3
show the reaction diagram
propionamide + H2O
propionic acid + NH3
show the reaction diagram
propionohydrazide + H2O
hydrazine + propionate
show the reaction diagram
-
-
-
?
propionohydroxamate + H2O
hydroxylamine + propionate
show the reaction diagram
-
-
-
?
RCONH2 + H2O
RCOOH + NH3
show the reaction diagram
succinamic acid + H2O
succinic acid + NH3
show the reaction diagram
Blastobacter sp.
-
-
-
?
valeramide + H2O
valerate + NH3
show the reaction diagram
additional information
?
-