Literature summary for 3.5.1.4 extracted from

Vinod, K.Y.; Sanguino, E.; Yalamanchili, R.; Manzanares, J.; Hungund, B.L.
Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol (2008), J. Neurochem., 104, 233-243.

Search for more literature for 3.5.1.4

Application

Application	Comment	Organism
medicine	down-regulated state of FAAH - through its effects on CB1 and opioid receptor in the brain reward circuitry - promotes ethanol drinking behavior. Manipulation of the FAAH activity might represent a novel therapeutic target for the treatment of ethanol dependence	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
3'-{[(E)-(cyclohexylimino)(hydroxy)methyl]oxy}biphenyl-3-carboximidic acid	the inhibitor markedly increases the preference for ethanol. The inhibitor specifically acts through FAAH	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	FAAH is a key regulator in the development of ethanol dependence	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	FAAH is a key regulator in the development of ethanol dependence	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
FAAH	-	Mus musculus
fatty acid amide hydrolase	-	Mus musculus

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Release 2023.1 (January 2023)