Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.4 extracted from

  • Sit, S.Y.; Conway, C.; Bertekap, R.; Xie, K.; Bourin, C.; Burris, K.; Deng, H.
    Novel inhibitors of fatty acid amide hydrolase (2007), Bioorg. Med. Chem. Lett., 17, 3287-3291.
    View publication on PubMed
Search for more literature for 3.5.1.4

Application

Application Comment Organism
medicine FAAH inhibition shows potential utility for the clinical treatment of persistent and neuropathic pain Homo sapiens
medicine FAAH inhibition shows potential utility for the clinical treatment of persistent and neuropathic pain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-[6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]-3-phenylurea
-
 Homo sapiens
2,6-difluorophenyl [6-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]hexyl]carbamate
-
 Homo sapiens
2-fluorophenyl [1-ethyl-6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
2-fluorophenyl [1-methyl-6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)-1-(1-methylethyl)hexyl]carbamate
-
 Homo sapiens
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)-1-phenylhexyl]carbamate
-
 Homo sapiens
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models of persistent (formalin test) and neuropathic (Chung model) pain Rattus norvegicus
2-fluorophenyl [6-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]hexyl]carbamate
-
 Homo sapiens
ethyl 4-[3-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]butanoate
-
 Homo sapiens
ethyl 4-[4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]butanoate
-
 Homo sapiens
ethyl 6-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)hexanoate
-
 Homo sapiens
ethyl 7-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)heptanoate
-
 Homo sapiens
ethyl 7-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]heptanoate
-
 Homo sapiens
ethyl 8-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)octanoate
-
 Homo sapiens
methyl [3-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
-
 Homo sapiens
methyl [4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
-
 Homo sapiens
N,N-dimethyl-7-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)heptanamide
-
 Homo sapiens
N-methyl-7-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)heptanamide
-
 Homo sapiens
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000016
-
 phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
0.000002
-
 2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
0.0000042
-
 2-fluorophenyl [1-methyl-6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
0.00001
-
 2-fluorophenyl [6-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]hexyl]carbamate
-
 Homo sapiens
0.000011
-
 ethyl 7-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)heptanoate
-
 Homo sapiens
0.000024
-
 2,6-difluorophenyl [6-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]hexyl]carbamate
-
 Homo sapiens
0.00003
-
 2-fluorophenyl [1-ethyl-6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
 Homo sapiens
0.000031
-
 ethyl 8-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)octanoate
-
 Homo sapiens
0.000032
-
 ethyl 6-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)hexanoate
-
 Homo sapiens
0.000064
-
 ethyl 4-[4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]butanoate
-
 Homo sapiens
0.000064
-
 ethyl 7-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]heptanoate
-
 Homo sapiens
0.000091
-
 ethyl 4-[3-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]butanoate
-
 Homo sapiens
0.00011
-
 2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)-1-phenylhexyl]carbamate
-
 Homo sapiens
0.00025
-
 2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)-1-(1-methylethyl)hexyl]carbamate
-
 Homo sapiens
0.00067
-
 methyl [4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
-
 Homo sapiens
0.00097
-
 N,N-dimethyl-7-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)heptanamide
-
 Homo sapiens
0.0017
-
 N-methyl-7-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)heptanamide
-
 Homo sapiens
0.0065
-
 methyl [3-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
-
 Homo sapiens
0.01
-
 1-[6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]-3-phenylurea
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000002
-
-
 Rattus norvegicus 2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate