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3.5.1.4: amidase

This is an abbreviated version!
For detailed information about amidase, go to the full flat file.

Word Map on EC 3.5.1.4

Reaction

a monocarboxylic acid amide
+
H2O
=
a monocarboxylate
 +
NH3

Synonyms

4-guanidinobutyramide hydrolase, A-amidase, acetamidase, acid transferase, acylamidase, acylase, AMI1, amidase, amidase 1, amide hydrolase, amide transferase, amidohydrolase, AmiE, Ana, anandamide hydrolase, AtFAAH, Azl13, C-amidase, deaminase, ester transferase, FAAH, FAAH-1, FAAH-2, fatty acid amide hydrolase, fatty acid amide hydrolase 1, fatty acylamidase, half-amidase, indole-3-acetamide amidohydrolase, K1, mHG, Mhpg, More, murein peptide amidase A, mycothiol-S-conjugate amidase, N-acetylaminohydrolase, N-acylethanolamine acid amidase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, NAE-hydrolyzing acid amidase, PamH, PYCH_10400, R-stereospecific amidase, RhAmidase, signature amidase, SsAH, SSAM, SSO2122, tissue kallikrein, Wide spectrum amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.4 amidase

Inhibitors

Inhibitors on EC 3.5.1.4 - amidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+/-)-(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
-
-
(+/-)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(+/-)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
(+/-)-oxiran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
(+/-)-oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
(+/-)-oxiran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
(+/-)-oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
(+/-)-oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
(+/-)-oxiran-2-ylmethyl benzoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
(+/-)-tetrahydro-2H-pyran-2-ylmethyl benzoate
-
-
(2R,3R)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
(2R,3S)-2-methyl-4-oxo-3-oxetanylcarbamic acid benzyl ester
(2R,3S)-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid 5-phenylpentyl ester
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid benzyl ester
(2S,3R)-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
(2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
(5Z,8Z,11Z,14Z)-eicosantetraenoic acid 3-thienyl methyl ester
(R)-(2-oxo-3-oxetanyl)carbamic acid tert-butyl ester
(R)-1-methyl-3-(2-oxo-3-oxetanyl)urea
(R)-2-oxo-3-oxetanylcarbamic acid benzyl ester
(R,S)-2-oxocyclobutylcarbamic acid benzyl ester
(S)-(2-oxo-3-oxetanyl)carbamic acid tert-butyl ester
(S)-1-methyl-3-(2-oxo-3-oxetanyl)urea
(S)-2-oxo-3-oxetanylcarbamic acid benzyl ester
1,10-phenanthroline
20-30% inhibition at 1 mM
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
1-(1,3-oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one
-
-
1-(1,3-oxazol-2-yl)-3-[4-(phenoxymethyl)phenyl]propan-1-one
-
-
1-(1,3-oxazol-2-yl)-4-piperidin-4-ylbutan-1-one
-
-
1-(1,3-oxazol-2-yl)-4-[1-(3-phenylpropanoyl)piperidin-4-yl]butan-1-one
-
-
1-(1,3-oxazol-2-yl)-4-[1-(phenylacetyl)piperidin-4-yl]butan-1-one
-
-
1-(1,3-oxazol-2-yl)-4-[1-(phenylsulfonyl)piperidin-4-yl]butan-1-one
-
-
1-(1,3-oxazol-2-yl)-4-[1-[(2-phenylethyl)sulfonyl]piperidin-4-yl]butan-1-one
-
-
1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-3-[4-(phenoxymethyl)phenyl]propan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-(2-thienyl)heptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-(3-thienyl)heptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[2-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[2-(trifluoromethyl)phenyl]heptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[3-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[3-(trifluoromethyl)phenyl]heptan-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[4-(trifluoromethyl)phenyl]hept-6-yn-1-one
-
-
1-(5-pyridin-2-yl-1,3-oxazol-2-yl)-7-[4-(trifluoromethyl)phenyl]heptan-1-one
-
-
1-([4'-[3-(1,3-oxazol-2-yl)propyl]biphenyl-4-yl]methyl)piperidine
-
-
1-arachidin
-
10% inhibition at 0.1 mM
1-arachidonoylglycerol
1-myristin
-
IC50: 0.018, complete inhibition is possible
1-nor-arachidonoyl-3-(2'3-dihydroxypropyl) urea
-
i.e. O-1502, complete inhibition at 0.1 mM
1-palmitin
-
IC50: 0.0080, complete inhibition is possible
1-[6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]-3-phenylurea
-
-
11-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)undecan-1-one
-
-
2,3-dihydroxypropyl (11Z)-icos-11-enoate
-
i.e. O-4066, IC50: 0.010, complete inhibition is possible
2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate
-
i.e. O-3907, IC50: 0.0057, complete inhibition is possible
2,3-dihydroxypropyl (4Z,7Z,10Z,13Z)-17-ethylcycloheptadeca-4,7,10,13-tetraene-1-carboxylate
-
i.e. O-1428, 28% inhibition at 0.1 mM
2,3-dihydroxypropyl (5Z)-icos-5-enoate
-
i.e. 3908, IC50: 0.011, 84% inhibition is possible
2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate
-
i.e. O-3973, IC50: 0.0024, 95% inhibition is possible
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
-
i.e. O-3832, IC50: 0.0076, complete inhibition is possible
2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate
-
i.e. O-4081, IC50: 0.0051, 90% inhibition is possible
2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate
-
i.e. O-3872, IC50: 0.014, complete inhibition is possible
2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate
-
i.e. 3846, IC50: 0.023, complete inhibition is possible
2,6-difluorophenyl [6-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]hexyl]carbamate
-
-
2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazole-5-carbonitrile
-
-
2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazole-5-carboxamide
-
-
2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazole-5-carboxylic acid
-
-
2-(3-biphenyl-4-ylpropanoyl)-N,N-dimethyl-1,3-oxazole-5-carboxamide
-
-
2-(4-phenylbutoxy)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbonitrile
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylic acid
-
-
2-(hexadecyloxy)ethanamine
-
70% inhibition at 0.1 mM
2-aminoethyl decanoate
-
11% inhibition at 0.1 mM
2-aminoethyl dodecanoate
-
26% inhibition at 0.1 mM
2-aminoethyl hexadecanoate
-
50% inhibition at 0.1 mM
2-aminoethyl tetradecanoate
-
54% inhibition at 0.1 mM
2-arachidonoylglycerol
-
37% inhibition at 0.1 mM
2-chloro-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-dodecyloxy-1-ethylamine
-
49% inhibition at 0.1 mM
2-fluorophenyl [1-ethyl-6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
-
2-fluorophenyl [1-methyl-6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
-
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)-1-(1-methylethyl)hexyl]carbamate
-
-
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)-1-phenylhexyl]carbamate
-
-
2-fluorophenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
2-fluorophenyl [6-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]hexyl]carbamate
-
-
2-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
2-mercaptoethanol
2-tetradecyloxy-1-ethylamine
-
71% inhibition at 0.1 mM
2-[(4-phenylbutyl)sulfinyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-[(4-phenylbutyl)sulfonyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-[(4-phenylbutyl)thio]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carbonitrile
2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxamide
-
-
2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxylic acid
-
-
2-[3-(benzyloxy)phenoxy]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carbonitrile
2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxylic acid
-
-
2-[4-(benzyloxy)phenoxy]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanone
-
-
2-[methyl(4-phenylbutyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)ethanol
-
-
3'-(aminocarbonyl)biphenyl-3-yl cyclohexylcarbamate
-
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
-
3'-{[(E)-(cyclohexylimino)(hydroxy)methyl]oxy}biphenyl-3-carboximidic acid
-
the inhibitor markedly increases the preference for ethanol. The inhibitor specifically acts through FAAH
3-(2-naphthyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(3-phenylpropoxy)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-anilinophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-benzylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-phenoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-(4-phenoxyphenyl)-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
3-(4-phenylbutyl)oxetan-2-one
3-aminopropyl decanoate
-
45% inhibition at 0.1 mM
3-aminopropyl dodecanoate
-
37% inhibition at 0.1 mM
3-aminopropyl hexadecanoate
-
52% inhibition at 0.1 mM
3-aminopropyl tetradecanoate
-
54% inhibition at 0.1 mM
3-biphenyl-4-yl-1-(1,3-oxazol-2-yl)propan-1-one
-
-
3-biphenyl-4-yl-1-(5-iodo-1,3-oxazol-2-yl)propan-1-one
-
-
3-biphenyl-4-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
3-biphenyl-4-yl-1-(5-pyridin-3-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-biphenyl-4-yl-1-(5-pyridin-4-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-biphenyl-4-yl-1-[5-(methylthio)-1,3-oxazol-2-yl]propan-1-one
-
-
3-biphenyl-4-yl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]propan-1-one
-
-
3-biphenyl-4-yl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
-
-
3-biphenyl-4-yl-1-[5-[6-(1H-tetrazol-1-yl)pyridin-2-yl]-1,3-oxazol-2-yl]propan-1-one
-
-
3-dodecyloxy-1-propanamine
-
27% inhibition at 0.1 mM
3-hexadecyloxy-1-propanamine
-
16% inhibition at 0.1 mM
3-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
3-tetradecyloxy-1-propanamine
-
29% inhibition at 0.1 mM
3-[3-(benzyloxy)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[4-(benzyloxy)cyclohexa-1,5-dien-1-yl]-1-[1,3]oxazolo[4,5-b]pyridin-2-ylpropan-1-one
-
-
3-[4-(benzyloxy)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
3-[4-(phenoxymethyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
3-[4-(phenoxymethyl)phenyl]-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]propan-1-one
3-[4-(phenoxymethyl)phenyl]-1-[5-[6-(1H-tetrazol-5-yl)pyridin-2-yl]-1,3-oxazol-2-yl]propan-1-one
-
-
3-[4-(phenylthio)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[4-[hydroxy(phenyl)methyl]cyclohexa-1,5-dien-1-yl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
3-[4-[hydroxy(phenyl)methyl]phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
3-[methyl(3-phenylpropyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-1-one
-
-
4-(1-benzoylpiperidin-4-yl)-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-(1-benzylpiperidin-4-yl)-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-(2-phenylethoxy)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)butan-1-one
-
-
4-(benzyloxy)phenyl butylcarbamate
-
4-chloromercuribenzoic acid
-
as -SH-blocking reagent, substrate 4-nitroacetanilide, incubation 10 min, 10 micromol 4-chloromercuribenzoic acid, residual activity 4.8%, activity restored by addition of 1 mM cysteine, 1 h incubation 67% restored
4-chloromercurybenzoate
-
4-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
4-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(2-bromobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(2-chlorobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(2-methoxybenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(2-methylbenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(3,3-dimethylbutanoyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(3-bromobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(3-chlorobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(3-cyclohexylpropanoyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(3-methoxybenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(3-methylbenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(4-bromobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(4-chlorobenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(4-methoxybenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(4-methylbenzyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(benzylsulfonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(cyclohexylacetyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(cyclohexylcarbonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(cyclopropylcarbonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-(isopropylsulfonyl)piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-[3-(1-methylethoxy)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-[3-(1-methylethyl)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-[4-(1-methylethoxy)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[1-[4-(1-methylethyl)benzyl]piperidin-4-yl]-1-(1,3-oxazol-2-yl)butan-1-one
-
-
4-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
4-[methyl(2-phenylethyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)butan-1-one
-
-
5-(benzyloxy)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
-
-
5-(benzylsulfinyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
-
-
5-(benzylthio)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
5-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
5-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
-
-
5-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
5-[benzyl(methyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentan-1-one
6-(2-[3-[4'-(morpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(piperidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4'-(thiomorpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carbonitrile
-
-
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-3-carboxylic acid
-
-
6-(2-[3-[4-(piperidin-4-yloxy)phenyl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylic acid
-
-
6-(benzyloxy)-N-[(3S)-2-oxooxetan-3-yl]naphthalene-2-carboxamide
6-(phenylsulfinyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
6-(phenylsulfonyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
6-(phenylthio)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
6-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
6-methoxy-N-[(3S)-2-oxooxetan-3-yl]naphthalene-2-carboxamide
6-oxo-N-phenyl-6-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexanamide
-
-
6-phenoxy-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
6-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]nicotinic acid
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]nicotinamide
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]nicotinic acid
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carbonitrile
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]nicotinamide
-
-
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]nicotinic acid
-
-
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(3-[4'-[(4-aminopiperazin-1-yl)methyl]biphenyl-4-yl]propyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]nicotinic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carbonitrile
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]nicotinic acid
-
-
6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-[3-(4-[[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy]phenyl)propyl]-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[methyl(phenyl)amino]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexan-1-one
-
-
7-(2,3-dichlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(2,3-dichlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
7-(2-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(2-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(2-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(2-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(2-methoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(2-methylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(2-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(3-aminophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(3-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(3-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(3-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(3-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(3-methoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(3-methylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(3-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(4-aminophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(4-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(4-chlorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(4-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(4-fluorophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(4-methoxyphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(4-methylphenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-(4-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-(4-nitrophenyl)-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-hydroxy-7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-naphthalen-1-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-naphthalen-2-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
7-phenyl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[6-(1H-tetrazol-5-yl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-pyridin-2-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-pyridin-2-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-pyridin-3-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-pyridin-3-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-pyridin-4-yl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-6-yn-1-one
-
-
7-[2-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[3-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[3-(tert-butylamino)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[4-(methylsulfanyl)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-[4-(tert-butylamino)phenyl]-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
8-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)octan-1-one
-
-
9-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)nonan-1-one
-
-
acetaldehyde
acetaldehyde ammonia
-
-
acetamide
acetanilide
-
substrate 4-nitroacetanilide, Ki: 14 micromol, competitive inhibition
acetic acid
acetone
acetonitrile
-
5% v/v, 93% inhibition; 93% decreased activity at 5% (v/v)
acetonnitrile
-
Ki: 120 mM
Acrylamide
-
substrate inhibition
acrylonitrile
-
Ki: 34 mM
alpha-methyl-1-arachidonoylglycerol
-
IC50: 0.033 mM, complete inhibition at 0.1 mM
ammonia
-
non-competitive product inhibitor at pH 9.0
arachidonic acid
-
IC50: 0.058 mM, complete inhibition at 0.1 mM
arachidonoyl glycine
-
IC50: 0.0049 mM, complete inhibition at 0.1 mM
arachidonoyl serinol
-
IC50: 0.078 mM, complete inhibition at 0.1 mM
arachidonoyl serotonin
-
more potent inhibitor at pH 8.4 than at pH 5.3
aromatic amide
-
-
benzyl 4-[4-(1,3-oxazol-2-yl)-4-oxobutyl]piperidine-1-carboxylate
-
-
Butyric acid
-
-
CaCl2
-
relative activity 91.7%, incubated for 10 min
CAY10400
-
-
Chloroacetone
-
pH 8.66, 25°C, irreversible strong inhibition at concentrations of 0.1 mM and above, acetamide protects enzyme from inhibition and slowly recovers activity of inactivated enzyme
Cyanate
-
Ki of strain AI3 is 1.1 mM, Ki of strain AIU1N is 1.8 mM and Ki of strain OUCH4 is 50 mM; reversible inhibition, pH 7.2 and 37°C
cyclobutylcarbamic acid benzyl ester
cyclopentyl(5-pyridin-2-yl-1,3-oxazol-2-yl)methanone
-
-
cyclopropyl(5-pyridin-2-yl-1,3-oxazol-2-yl)methanone
-
-
diethyl dicarbonate
-
-
Diethyl-4-nitrophenyl phosphate
-
-
diisopropylphosphorofluoridate
-
-
Dimethyl sulfide
-
5% v/v, complete inhibition; complete inhibition at 5% (v/v)
dimethyl sulfoxide
-
5% v/v, complete inhibition; complete inhibition at 5% (v/v)
dithiothreitol
DNA containing thymine glycol
-
dodecyl 2-aminoacetate
-
66% inhibition at 0.1 mM
dodecyl 3-aminopropanoate
-
27% inhibition at 0.1 mM
DTT
-
21% inhibition at 1 mM
ethanol
ethyl 4-[3-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]butanoate
-
-
ethyl 4-[4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]butanoate
-
-
ethyl 6-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)hexanoate
-
-
ethyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
ethyl 6-[[(3S)-2-oxooxetan-3-yl]carbamoyl]naphthalene-2-carboxylate
ethyl 7-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)heptanoate
-
-
ethyl 7-[4,5-bis(4-fluorophenyl)-2-methyl-1H-imidazol-1-yl]heptanoate
-
-
ethyl 8-(2-ethyl-4,5-diphenyl-1H-imidazol-1-yl)octanoate
-
-
H2O2
-
5% v/v, complete inhibition; complete inhibition at 5% (v/v) H2O2
heptadecanoic acid
-
-
hexadecyl 2-aminoacetate
-
29% inhibition at 0.1 mM
hexadecylamine
-
-
hexadecyltrimethylammonium chloride
-
-
hydroxylamine
-
competitive inhibitor at pH 7.2
Hydroxyurea
-
Ki of strain AI3 is 1.4 mM, Ki of strain AIU1N is 10.8 mM and Ki of strain OUCH4 is 337 mM, regaines full activity within 24 h at 37°C in 0.05 M Tris buffer at pH 7.2; reversible inhibition, pH 7.2 and 37°C
Ibuprofen
-
both enantiomers, more potent inhibitors at pH 5.3 than at pH 8.4
iodoacetamide
iodoacetate
Isopropanol
isopropyl 4-[4-(1,3-oxazol-2-yl)-4-oxobutyl]piperidine-1-carboxylate
-
-
K+
-
1-linear competitive inhibition of the amidase activity
L-ascorbic acid
-
19% inhibition at 1 mM
mercaptoethanol
-
5% v/v, complete inhibition
Methacrylonitrile
-
Ki: 90 mM
methanol
methyl 2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazole-5-carboxylate
methyl 2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazole-5-sulfinate
-
-
methyl 2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylate
-
-
methyl 2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxylate
-
-
methyl 2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxylate
-
-
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
methyl 2-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzoate
-
-
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
methyl 3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzoate
-
-
methyl 4-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]benzoate
-
-
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzenesulfinate
-
-
methyl 4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptyl]benzoate
-
-
methyl 5-oxo-5-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentanoate
-
-
methyl 5-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(morpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(piperidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(pyrrolidin-1-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4'-(thiomorpholin-4-ylmethyl)biphenyl-4-yl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazol-5-yl)pyridine-3-carboxylate
-
-
methyl 6-(2-[3-[4-(piperidin-4-yloxy)phenyl]propyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-oxo-6-(5-pyridin-2-yl-1,3-oxazol-2-yl)hexanoate
-
-
methyl 6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-yl-1-hydroxypropyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
methyl 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(3-biphenyl-4-ylpropyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-(3-[4'-[(dimethylamino)methyl]biphenyl-4-yl]propyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 6-[2-[3-(4-[[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy]phenyl)propyl]-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl [3-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
-
-
methyl [4-(4,5-diphenyl-1H-imidazol-1-yl)phenoxy]acetate
-
-
MnCl2
-
relative activity 94.4%, incubated for 10 min
N,N-dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N,N-dimethyl-2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxamide
-
-
N,N-dimethyl-2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
N,N-dimethyl-7-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)heptanamide
-
-
N-(4-hydroxy-2-methylphenyl)arachidonylamide
-
i.e. VDM11, an anandamide uptake inhibitor, IC50 is 0.0026 mM, inhibitory potency depends upon the concentration of bovine serum albumin
N-(4-hydroxyphenyl)arachidonylamide
-
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM
N-(cyclohexylcarbonyl)pentadecylamine
N-benzyl-5-oxo-5-(5-pyridin-2-yl-1,3-oxazol-2-yl)pentanamide
-
-
n-butanol
-
48% decreased activity at 5% (v/v); 5% v/v, 48% inhibition
N-ethylmaleimide
-
inhibition at 10 mM, C-amidase
N-methyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-methyl-2-[3-(4-phenoxyphenyl)propanoyl]-1,3-oxazole-5-carboxamide
-
-
N-methyl-2-[3-[4-(phenoxymethyl)phenyl]propanoyl]-1,3-oxazole-5-carboxamide
-
-
N-methyl-7-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)heptanamide
-
-
N-methylpropionamide
-
amide analogue, inhibits the biosynthesis of acetamidase, strain R312
N-[(3S)-2-oxooxetan-3-yl]biphenyl-4-carboxamide
N-[(3S)-2-oxooxetan-3-yl]naphthalene-2-carboxamide
N-[(benzyloxy)carbonyl]-D-serine
N-[(benzyloxy)carbonyl]-L-serine
NH3
-
selective product inhibition
noladin ether
-
IC50: 0.003 mM, complete inhibition at 0.1 mM
o-Nitrophenol
-
competitive inhibition
oleoyltrifluoromethylketone
-
more potent inhibitor at pH 5.3 than at pH 8.4
OMDM2
-
0.01 mM, 16% inhibition
p-chloromercuribenzoate
-
relative activity 36.1%, incubated for 10 min
p-hydroxymercuribenzoate
PEG
-
8% inhibition at 1 mM
pentadecyl 2-aminoacetate
-
56% inhibition at 0.1 mM
pentadecyl 3-aminopropanoate
-
27% inhibition at 0.1 mM
pentadecylamine
-
-
Phenacetin
-
substrate 4-nitroacetanilide, Ki: 8.9 nM, competitive inhibition, induction of activity for 2-nitrophenylacetate and methylbutyrate
Phenetidine
-
uncompetitive inhibition
phenyl 6-[[(3S)-2-oxooxetan-3-yl]carbamoyl]naphthalene-2-carboxylate
phenyl hydrazine
-
complete inhibition at 1 mM
phenyl [6-(2-methyl-4,5-diphenyl-1H-imidazol-1-yl)hexyl]carbamate
-
-
phenylmethanesulfonyl fluoride
phenylmethyl sulfonyl fluoride
-
more potent inhibitor at pH 8.4 than at pH 5.3
phenylphosphorodiamidate
-
competitive inhibitor, the inhibitory effect is fully reversed by SSAM substrate benzamide, demonstrating the hydrophobicity of the active site
physostigmine sulfate
-
-
propionic acid
-
-
Propionitrile
-
Ki: 280 mM
specific iron chelator
-
-
-
suberoylanilide hydroxamic acid
strong inhibition
succinate
Blastobacter sp.
-
-
sulfhydyl reagents
Blastobacter sp.
-
-
-
tert-butyl 4-[4-(1,3-oxazol-2-yl)-4-oxobutyl]piperidine-1-carboxylate
-
-
tert-butyl [3-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]phenyl]carbamate
-
-
tert-butyl [4-[7-oxo-7-(5-pyridin-2-yl-1,3-oxazol-2-yl)hept-1-yn-1-yl]phenyl]carbamate
-
-
tetradecyl 2-aminoacetate
-
84% inhibition at 0.1 mM
tetradecylamine
-
-
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
Thioacetamide
-
amide analogues, inhibits the biosynthesis of acetamidase, strain R312
thiol blocking reagent
-
-
-
tricostatin A
strong inhibition
tridecyl 2-aminoacetate
-
89% inhibition at 0.1 mM
tridecyl 3-aminopropanoate
-
27% inhibition at 0.1 mM
Triton X-100
-
undecylamine
-
-
URB597
Valeric acid
-
-
additional information
-