3.4.22.59: caspase-6
This is an abbreviated version!
For detailed information about caspase-6, go to the full flat file.
Word Map on EC 3.4.22.59
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3.4.22.59
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caspases
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bcl-2
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alzheimer
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neurodegenerative
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pro-apoptotic
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huntington
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lamins
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apoptosis-related
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parp
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executioner
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caspase-dependent
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anti-apoptotic
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polyadp-ribose
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tunel
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caspase-mediated
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casps
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jurkat
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bid
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pan-caspase
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zvad-fmk
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apaf-1
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medicine
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procaspase-3
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fadd
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diagnostics
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fas-associated
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drug development
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molecular biology
- 3.4.22.59
-
caspases
- bcl-2
- alzheimer
- neurodegenerative
-
pro-apoptotic
- huntington
- lamins
-
apoptosis-related
- parp
-
executioner
-
caspase-dependent
-
anti-apoptotic
-
polyadp-ribose
-
tunel
-
caspase-mediated
-
casps
-
jurkat
- bid
-
pan-caspase
- zvad-fmk
- apaf-1
- medicine
- procaspase-3
- fadd
- diagnostics
-
fas-associated
- drug development
- molecular biology
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-/- =
Synonyms
apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, HLcaspase-6, MCH2, Pfcasp-6, VEIDase
ECTree
3.4.22.59 caspase-6Advanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.22.59 - caspase-6
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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A549 cell line infected by unencapsulated Streptococcus pneumoniae type 2 strain R6x and capsulated Streptococcus pneumoniae strain D39 and the pneumolysin-deficient R6xply mutant
after the challenges of high temperatures and Aeromonas hydrophila, the transcript expressions of Pfcasp-6 are significantly upregulated in blood and spleen
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BEAS-2B cell line infected by unencapsulated Streptococcus pneumoniae type 2 strain R6x
expression of HLcaspase-6 mRNA in coelomocytes is significantly upregulated by lipopolysaccharides or polyriboinosinic-polyribocytidylic acid [poly (I:C)] challenge
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keloid fioblasts show a decreased expression of apoptosis-related genes compared to scars
additional information
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caspase-6 is elevated in Huntington disease brain, active caspase-6 is present in post mortem brains of Huntington and Alzheimer disease subjects that do not yet display apoptotic morphology
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invasive operable pT1 and pT2 ductal breast carcinoma are analysed of 210 patients: caspase-6 is overexpressed in 52.9%
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a human hepatoma cell line expressing the sodium taurocholate cotransporting polypeptide, Ntcp
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transfected with Ntcp, sodium taurocholate cotransporting polypeptide
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a human hepatoma cell line expressing the sodium taurocholate cotransporting polypeptide, Ntcp
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primary neurons, active caspase-6 is localized in neuritic plaques, in neuropil threads, and in neurofibrillary tangles containing neurons that are not morphologically apoptotic in nature
expression of Casp6 protein and mRNA in distal branches of sensory axons undergoing axonal degeneration. Intra-axonal synthesis of Casp6 emerges at early time points following axotomy
after the challenges of high temperatures and Aeromonas hydrophila, the transcript expressions of Pfcasp-6 are significantly upregulated in blood and spleen
additional information
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p53 up-regulates caspase -6mRNA in H460, H460-neo, H460-E6, HCT16-neo, HCT16-E6, HCT16-P53-, SKBR3, U2OS, M3, HCC1937 and SW13 cell lines, MCF7 cells fail to show induction of caspase 6-mRNA
additional information
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present in neurophil threads and neuritic plaques, not in the cerebellum
additional information
whole mount in situ hybridisation of the salmon embryo shows expression in multiple tissues, cardiac expression is only shown in heat stressed embryos
additional information
whole mount in situ hybridisation of the salmon embryo shows expression in multiple tissues, cardiac expression is only shown in heat stressed embryos
