Application | Comment | Organism |
---|---|---|
medicine | difference between normal fiber cell differentation and apoptosis and the capacity of the lens to differentially regulate these two processes | Mus musculus |
medicine | difference between normal fiber cell differentation and apoptosis and the capacity of the lens to differentially regulate these two processes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-Leu-vinylsulfone | - |
Homo sapiens | |
beta-lactone | - |
Homo sapiens | |
epoxomicin | - |
Homo sapiens | |
IETD-CHO | caspase-6 in lens extracts from neonatal mice partially inhibited by 0.0005 mM | Mus musculus | |
lactacystin | - |
Homo sapiens | |
VEID-CHO | caspase-6 in lens extracts from neonatal mice efficiently inhibited by 0.0005 mM | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
neonatal FVB/n cell line and alphaAE7 transgenic mice line 75a (as a source of apoptotic lens cells) | - |
Rattus norvegicus | - |
E15.5-18.5 embryos from Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fiber | primary fiber cells | Rattus norvegicus | - |
lens | - |
Mus musculus | - |
lens | - |
Rattus norvegicus | - |
leukemia cell | THP-1 human monocytic cell culture | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
VEID-7-amido-4-trifluoromethylcoumarin cleavage acitivity overall increases by 6.1fold between E15.5 and E18.5 rat embryos | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IETD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Mus musculus | IETD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
IETD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | IETD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
IETD-7-amido-4-trifluoromethylcoumarin + H2O | very low cleavage activity | Rattus norvegicus | IETD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
VEID-7-amido-4-trifluoromethylcoumarin + H2O | - |
Rattus norvegicus | VEID + 7-amino-4-trifluoromethylcoumarin | - |
? | |
VEID-7-amido-4-trifluoromethylcoumarin + H2O | preferred substrate for caspase-6 | Mus musculus | VEID + 7-amino-4-trifluoromethylcoumarin | - |
? | |
VEID-7-amido-4-trifluoromethylcoumarin + H2O | preferred substrate for caspase-6 | Homo sapiens | VEID + 7-amino-4-trifluoromethylcoumarin | - |
? |