Literature summary for 3.4.22.59 extracted from

Guo, H.; Petrin, D.; Zhang, Y.; Bergeron, C.; Goodyer, C.G.; LeBlanc, A.C.
Caspase-1 activation of caspase-6 in human apoptotic neurons (2006), Cell Death Differ., 13, 285-292.

Search for more literature for 3.4.22.59

Activating Compound

Activating Compound	Comment	Organism	Structure
caspase-1	caspase-1 activates caspase-6 in vitro	Homo sapiens

Application

Application	Comment	Organism
molecular biology	the results show that caspase-1 is an upstream positive regulator of caspase-6-mediated cell death in primary human neurons	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
BOC-Asp(OMe)-fluoromethyl ketone	for general caspase inhibition	Homo sapiens
Z-IETD-fluoromethylketone	for Csp-6- and caspase-8-like inhibition	Homo sapiens
Z-VEID-fluoromethylketone	for Csp-6-like inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuronal cell line	human primary neuronal culture	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O	-	Homo sapiens	N-acetyl-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
caspase-6	-	Homo sapiens
Csp-6	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	-	Homo sapiens

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Release 2023.1 (January 2023)