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Literature summary for 3.4.22.59 extracted from

  • Fernandes-Alnemri, T.; Litwack, G.; Alnemri, E.S.
    Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family (1995), Cancer Res., 55, 2737-2742.
    View publication on PubMed
Search for more literature for 3.4.22.59

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 Mch2alpha transcript encodes the full-length Mch2, whereas the Mch2beta transcript encodes a shorter Mch2 isoform, probably as a result of alternative slicing Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poly(ADP-ribose)polymerase + H2O Homo sapiens the enzyme may participate in poly(ADP-ribose)polymerase cleavage observed during apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55212
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
T-cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens DEVD + 7-amino-4-methylcoumarin
-
 ?
additional information Mch2alpha but not Mch2beta possesses protease activity Homo sapiens ?
-
 ?
poly(ADP-ribose)polymerase + H2O
-
 Homo sapiens ?
-
 ?
poly(ADP-ribose)polymerase + H2O the enzyme may participate in poly(ADP-ribose)polymerase cleavage observed during apoptosis Homo sapiens ?
-
 ?