Literature summary for 3.4.22.59 extracted from

Woo, V.; Cheng, C.; Duraikannu, A.; Chandrasekhar, A.; Purdy, K.; Martinez, J.A.; Zochodne, D.W.
Caspase-6 is a dispensable enabler of adult mammalian axonal degeneration (2018), Neuroscience, 371, 242-253 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
axon	expression of Casp6 protein and mRNA in distal branches of sensory axons undergoing axonal degeneration. Intra-axonal synthesis of Casp6 emerges at early time points following axotomy	Mus musculus	30424	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O08738	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	expression of Casp6 protein and mRNA in distal branches of sensory axons undergoing axonal degeneration. Intra-axonal synthesis of Casp6 emerges at early time points following axotomy	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Casp6	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	caspase-6 inhibition or knockdown slows the progress of axon damage in serially imaged cutaneous nerves. Inhibition of caspase-6 delays neurofilament dissolution following nerve resection. Mice lacking Casp6 exhibit subtle delays in axonal degeneration	Mus musculus
physiological function	increases in capase-6 expression and action contribute to the progression of axonal degeneration	Mus musculus

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Release 2023.1 (January 2023)