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3.4.22.59: caspase-6

This is an abbreviated version!
For detailed information about caspase-6, go to the full flat file.

Word Map on EC 3.4.22.59

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-/- =

Synonyms

apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, HLcaspase-6, MCH2, Pfcasp-6, VEIDase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.59 caspase-6

Reference

Reference on EC 3.4.22.59 - caspase-6

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P55212)
Manually annotated by BRENDA team
Srinivasula, S.M.; Fernandes-Alnemri, T.; Zangrilli, J.; Robertson, N.; Armstrong, R.C.; Wang, L.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri E.S.
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
J. Biol. Chem.
271
27099-27106
1996
Homo sapiens (P55212)
Manually annotated by BRENDA team
Nakajima, K.; Takahashi, A.; Yaoita, Y.
Structure, expression, and function of the Xenopus laevis caspase family
J. Biol. Chem.
275
10484-10491
2000
Xenopus laevis
Manually annotated by BRENDA team
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Manually annotated by BRENDA team
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Manually annotated by BRENDA team
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
Manually annotated by BRENDA team
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
Manually annotated by BRENDA team
van de Craen, M.; Berx, G.; van den Brande, I.; Fiers, W.; Declercq, W.; Vandenabeele, P.
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis
FEBS Lett.
458
167-170
1999
Mus musculus
Manually annotated by BRENDA team
Fernandes-Alnemri, T.; Litwack, G.; Alnemri, E.S.
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family
Cancer Res.
55
2737-2742
1995
Homo sapiens (P55212)
Manually annotated by BRENDA team
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
Mus musculus (O08738)
Manually annotated by BRENDA team
Cowling, V.; Downward, J.
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain
Cell Death Differ.
9
1046-1056
2002
Homo sapiens
Manually annotated by BRENDA team
Eleouet, J.F.; Slee, E.A.; Saurini, F.; Castagne, N.; Poncet, D.; Garrido, C.; Solary, E.; Martin, S.J.
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis
J. Virol.
74
3975-3983
2000
Homo sapiens
Manually annotated by BRENDA team
Galande, S.; Dickinson, L.A.; Mian, I.S.; Sikorska, M.; Kohwi-Shigematsu, T.
SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis
Mol. Cell. Biol.
21
5591-5604
2001
Homo sapiens
Manually annotated by BRENDA team
Mahoney, J.A.; Odin, J.A.; White, S.M.; Shaffer, D.; Koff, A.; Casciola-Rosen, L.; Rosen, A.
The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis
Biochem. J.
361
587-595
2002
Homo sapiens
Manually annotated by BRENDA team
Nyormoi, O.; Wang, Z.; Doan, D.; Ruiz, M.; McConkey, D.; Bar-Eli, M.
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells
Mol. Cell. Biol.
21
4856-4867
2001
Homo sapiens
Manually annotated by BRENDA team
Nyormoi, O.; Wang, Z.; Bar-Eli, M.
Sequence-based discovery of a synthetic peptide inhibitor of caspase 6
Apoptosis
8
371-376
2003
Homo sapiens
Manually annotated by BRENDA team
Hill, J.; Duckworth, M.; Murdock, P.; Rennie, G.; Sabido-David, C.; Ames, R.S.; Szekeres, P.; Wilson, S.; Bergsma, D.J.; Gloger, I.S.; Levy, D.S.; Chambers, J.K.; Muir, A.I.
Molecular cloning and functional characterization of MCH2, a novel human MCH receptor
J. Biol. Chem.
276
20125-20129
2001
Homo sapiens
Manually annotated by BRENDA team
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
9677-9682
1997
Homo sapiens
Manually annotated by BRENDA team
Samejima, K.; Svigen, P.A.; Basi, G.S.; Kottke, T.; Mesner, P.W.; Stewart, L.; Durrieu, F.; Poirier, G.G.; Alnemri, E.S.; Champoux, J.J.; Kaufmann, S.H.; Earnshaw, W.C.
caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis
J. Biol. Chem.
274
4335-4340
1999
Homo sapiens
Manually annotated by BRENDA team
Hirata, H.; Takahashi, A.; Kobayashi, S.; Yonehara, S.; Sawai, H.; Okazaki, T.; Yamamoto, K.; Sasada, M.
Caspases are activated in a branched protease cascade and control didtinct downstream processes in fas-induced apoptosis
J. Exp. Med.
187
587-600
1998
Homo sapiens
Manually annotated by BRENDA team
Guo, H.; Albrecht, S.; Bourdeau, M.; Petzke, T.; Bergeron, C.; LeBlanc, A.C.
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease
Am. J. Pathol.
165
523-531
2004
Homo sapiens
Manually annotated by BRENDA team
Kang, B.H.; Ko, E.; Kwon, O.K.; Choi, K.Y.
The structure of procaspase 6 is similar to that of active mature caspase 6
Biochem. J.
364
629-634
2002
Homo sapiens
Manually annotated by BRENDA team
Guo, H.; Petrin, D.; Zhang, Y.; Bergeron, C.; Goodyer, C.G.; LeBlanc, A.C.
Caspase-1 activation of caspase-6 in human apoptotic neurons
Cell Death Differ.
13
285-292
2006
Homo sapiens
Manually annotated by BRENDA team
Loegering, D.A.; Ruchaud, S.; Earnshaw, W.C.; Kaufmann, S.H.
Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis
Cell Death Differ.
13
346-347
2006
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Schmeck, B.; Gross, R.; N'Guessan, P.D.; Hocke, A.C.; Hammerschmidt, S.; Mitchell, T.J.; Rosseau, S.; Suttorp, N.; Hippenstiel, S.
Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium
Infect. Immun.
72
4940-4947
2004
Homo sapiens
Manually annotated by BRENDA team
Foley, J.D.; Rosenbaum, H.; Griep, A.E.
Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development
J. Biol. Chem.
279
32142-32150
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kalinin, A.E.; Kalinin, A.E.; Aho, M.; Uitto, J.; Aho, S.
Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region
J. Invest. Dermatol.
124
46-55
2005
Homo sapiens
Manually annotated by BRENDA team
Horowitz, P.M.; Patterson, K.R.; Guillozet-Bongaarts, A.L.; Reynolds, M.R.; Carroll, C.A.; Weintraub, S.T.; Bennett, D.A.; Cryns, V.L.; Berry, R.W.; Binder, L.I.
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
J. Neurosci.
24
7895-7902
2004
Homo sapiens
Manually annotated by BRENDA team
Narkilahti, S.; Pitkanen, A.
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy
Neuroscience
131
887-897
2005
Rattus norvegicus
Manually annotated by BRENDA team
Suzuki, A.; Kusakai, G.; Kishimoto, A.; Shimojo, Y.; Miyamoto, S.; Ogura, T.; Ochiai, A.; Esumi, H.
Regulation of caspase-6 and FLIP by the AMPK family member ARK5
Oncogene
23
7067-7075
2004
Homo sapiens
Manually annotated by BRENDA team
MacLachlan, T.K.; El-Deiry, W.S.
Apoptotic threshold is lowered by p53 transactivation of caspase-6
Proc. Natl. Acad. Sci. USA
99
9492-9497
2002
Homo sapiens
Manually annotated by BRENDA team
Lee, S.C.; Chan, J.; Clement, M.V.; Pervaiz, S.
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop
Proteomics
6
2386-2394
2006
Homo sapiens
Manually annotated by BRENDA team
Torres, F.; Quintana, J.; Diaz, J.G.; Carmona, A.J.; Estevez, F.
Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway
Apoptosis
13
716-728
2008
Homo sapiens
Manually annotated by BRENDA team
Garner, E.; Martinon, F.; Tschopp, J.; Beard, P.; Raj, K.
Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6
Cancer Res.
67
7631-7637
2007
Homo sapiens
Manually annotated by BRENDA team
Takle, H.; McLeod, A.; Andersen, O.
Cloning and characterization of the executioner caspases 3, 6, 7 and Hsp70 in hyperthermic Atlantic salmon (Salmo salar) embryos
Comp. Biochem. Physiol. B
144B
188-198
2006
Salmo salar (Q4ZHU8), Salmo salar (Q4ZHV1)
-
Manually annotated by BRENDA team
Blazquez, S.; Sirvent, J.J.; Olona, M.; Aguilar, C.; Pelegri, A.; Garcia, J.F.; Palacios, J.
Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study
Histol. Histopathol.
21
1321-1329
2006
Homo sapiens
Manually annotated by BRENDA team
Nassiri, M.; Woolery-Lloyd, H.; Ramos, S.; Jacob, S.E.; Gugic, D.; Viciana, A.; Romanelli, P.; Elgart, G.; Berman, B.; Vincek, V.
Gene expression profiling reveals alteration of caspase 6 and 14 transcripts in normal skin of keloid-prone patients
Arch. Dermatol. Res.
301
183-188
2009
Homo sapiens
Manually annotated by BRENDA team
Klaiman, G.; Champagne, N.; Leblanc, A.C.
Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells
Biochim. Biophys. Acta
1793
592-601
2009
Homo sapiens
Manually annotated by BRENDA team
Chan, J.Y.; Phoo, M.S.; Clement, M.V.; Pervaiz, S.; Lee, S.C.
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53
Cancer Biol. Ther.
7
1305-1312
2008
Homo sapiens
Manually annotated by BRENDA team
Chen, G.G.; Chan, U.P.; Bai, L.C.; Fung, K.Y.; Tessier, A.; To, A.K.; Merchant, J.L.; Lai, P.B.
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest
Cancer Lett.
283
52-58
2009
Homo sapiens
Manually annotated by BRENDA team
Eguchi, R.; Tone, S.; Suzuki, A.; Fujimori, Y.; Nakano, T.; Kaji, K.; Ohta, T.
Possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells
Exp. Cell Res.
315
327-335
2009
Homo sapiens
Manually annotated by BRENDA team
Warby, S.C.; Doty, C.N.; Graham, R.K.; Carroll, J.B.; Yang, Y.Z.; Singaraja, R.R.; Overall, C.M.; Hayden, M.R.
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
Hum. Mol. Genet.
17
2390-2404
2008
Mus musculus, Mus musculus YAC128
Manually annotated by BRENDA team
Rust, C.; Wild, N.; Bernt, C.; Vennegeerts, T.; Wimmer, R.; Beuers, U.
Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent
J. Biol. Chem.
284
2908-2916
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Watanabe, C.; Shu, G.L.; Zheng, T.S.; Flavell, R.A.; Clark, E.A.
Caspase 6 regulates B cell activation and differentiation into plasma cells
J. Immunol.
181
6810-6819
2008
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Chu, W.; Rothfuss, J.; Chu, Y.; Zhou, D.; Mach, R.H.
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6
J. Med. Chem.
52
2188-2191
2009
Homo sapiens
Manually annotated by BRENDA team
Klaiman, G.; Petzke, T.L.; Hammond, J.; Leblanc, A.C.
Targets of caspase-6 activity in human neurons and Alzheimer disease
Mol. Cell. Proteomics
7
1541-1555
2008
Homo sapiens
Manually annotated by BRENDA team
Chan, Y.W.; Chen, Y.; Poon, R.Y.
Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe
Oncogene
28
170-183
2009
Homo sapiens
Manually annotated by BRENDA team
Beretta, F.; Bassani, S.; Binda, E.; Verpelli, C.; Bello, L.; Galli, R.; Passafaro, M.
The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells
Eur. J. Neurosci.
30
25-34
2009
Homo sapiens
Manually annotated by BRENDA team
Baumgartner, R.; Meder, G.; Briand, C.; Decock, A.; Darcy, A.; Hassiepen, U.; Morse, R.; Renatus, M.
The crystal structure of caspase-6, a selective effector of axonal degeneration
Biochem. J.
423
429-439
2009
Homo sapiens (P55212)
Manually annotated by BRENDA team
Soares, J.; Lowe, M.M.; Jarstfer, M.B.
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate
Biochemistry
50
9046-9055
2011
Homo sapiens
Manually annotated by BRENDA team
Lee, A.W.; Champagne, N.; Wang, X.; Su, X.D.; Goodyer, C.; Leblanc, A.C.
Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A
J. Biol. Chem.
285
31974-31984
2010
Homo sapiens
Manually annotated by BRENDA team
Mueller, I.; Lamers, M.B.; Ritchie, A.J.; Park, H.; Dominguez, C.; Munoz-Sanjuan, I.; Maillard, M.; Kiselyov, A.
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme
J. Mol. Biol.
410
307-315
2011
Homo sapiens (P55212)
Manually annotated by BRENDA team
Mintzer, R.; Ramaswamy, S.; Shah, K.; Hannoush, R.N.; Pozniak, C.D.; Cohen, F.; Zhao, X.; Plise, E.; Lewcock, J.W.; Heise, C.E.
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin a/c
PLoS ONE
7
e30376
2012
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Graham, R.K.; Ehrnhoefer, D.E.; Hayden, M.R.
Caspase-6 and neurodegeneration
Trends Neurosci.
34
646-656
2011
Homo sapiens
Manually annotated by BRENDA team
Cho, J.H.; Lee, P.Y.; Son, W.C.; Chi, S.W.; Park, B.C.; Kim, J.H.; Park, S.G.
Identification of the novel substrates for caspase-6 in apoptosis using proteomic approaches
BMB Rep.
46
588-593
2013
Homo sapiens (P55212)
Manually annotated by BRENDA team
Shahzidi, S.; Brech, A.; Sioud, M.; Li, X.; Suo, Z.; Nesland, J.M.; Peng, Q.
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett.
339
25-32
2013
Homo sapiens
Manually annotated by BRENDA team
van Raam, B.J.; Ehrnhoefer, D.E.; Hayden, M.R.; Salvesen, G.S.
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
Cell Death Differ.
20
86-96
2013
Homo sapiens
Manually annotated by BRENDA team
LeBlanc, A.C.; Ramcharitar, J.; Afonso, V.; Hamel, E.; Bennett, D.A.; Pakavathkumar, P.; Albrecht, S.
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment
Cell Death Differ.
21
696-706
2014
Homo sapiens
Manually annotated by BRENDA team
Baburamani, A.A.; Miyakuni, Y.; Vontell, R.; Supramaniam, V.G.; Svedin, P.; Rutherford, M.; Gressens, P.; Mallard, C.; Takeda, S.; Thornton, C.; Hagberg, H.
Does caspase-6 have a role in perinatal brain injury?
Dev. Neurosci.
37
321-337
2015
Homo sapiens, Rattus norvegicus, Mus musculus (Q3TPJ9)
Manually annotated by BRENDA team
LeBlanc, A.C.
Caspase-6 as a novel early target in the treatment of Alzheimers disease
Eur. J. Neurosci.
37
2005-2018
2013
Homo sapiens (P55212), Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Velazquez-Delgado, E.M.; Hardy, J.A.
Zinc-mediated allosteric inhibition of caspase-6
J. Biol. Chem.
287
36000-36011
2012
Homo sapiens (P55212)
Manually annotated by BRENDA team
Lee, P.Y.; Cho, J.H.; Chi, S.W.; Bae, K.H.; Cho, S.; Park, B.C.; Kim, J.H.; Park, S.G.
Expression of the pro-domain-deleted active form of caspase-6 in Escherichia coli
J. Microbiol. Biotechnol.
24
719-723
2014
Homo sapiens (P55212)
Manually annotated by BRENDA team
Gafni, J.; Papanikolaou, T.; Degiacomo, F.; Holcomb, J.; Chen, S.; Menalled, L.; Kudwa, A.; Fitzpatrick, J.; Miller, S.; Ramboz, S.; Tuunanen, P.I.; Lehtimaeki, K.K.; Yang, X.W.; Park, L.; Kwak, S.; Howland, D.; Park, H.; Ellerby, L.M.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment
J. Neurosci.
32
7454-7465
2012
Mus musculus
Manually annotated by BRENDA team
Heise, C.E.; Murray, J.; Augustyn, K.E.; Bravo, B.; Chugha, P.; Cohen, F.; Giannetti, A.M.; Gibbons, P.; Hannoush, R.N.; Hearn, B.R.; Jaishankar, P.; Ly, C.Q.; Shah, K.; Stanger, K.; Steffek, M.; Tang, Y.; Zhao, X.; Lewcock, J.W.; Renslo, A.R.; Flygare, J.; Arkin, M.R.
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
PLoS ONE
7
e50864
2012
Homo sapiens (P55212)
Manually annotated by BRENDA team
Wang, X.; Cao, Q.; Zhang, Y.; Su, X.
Activation and regulation of caspase-6 and its role in neurodegenerative diseases
Annu. Rev. Pharmacol. Toxicol.
55
553-572
2015
Homo sapiens (P55212)
Manually annotated by BRENDA team
Suita, H.; Shinomiya, T.; Nagahara, Y.
Caspase-6 induces 7A6 antigen localization to mitochondria during FAS-induced apoptosis of Jurkat cells
Anticancer Res.
37
1697-1704
2017
Homo sapiens (P55212), Homo sapiens
Manually annotated by BRENDA team
Fu, S.; Ding, M.; Yang, Y.; Kong, J.; Li, Y.; Guo, Z.; Wang, A.; Ye, J.
Molecular cloning, characterization and expression analysis of caspase-6 in puffer fish (Takifugu obscurus)
Aquaculture
490
311-320
2018
Takifugu obscurus (H2TDB0)
-
Manually annotated by BRENDA team
Hogg, M.C.; Mitchem, M.R.; Koenig, H.G.; Prehn, J.H.
Caspase 6 has a protective role in SOD1(G93A) transgenic mice
Biochim. Biophys. Acta
1862
1063-1073
2016
Mus musculus (O08738), Mus musculus
Manually annotated by BRENDA team
Yan, A.; Ren, C.; Chen, T.; Huo, D.; Jiang, X.; Sun, H.; Hu, C.
A novel caspase-6 from sea cucumber Holothuria leucospilota Molecular characterization, expression analysis and apoptosis detection
Fish Shellfish Immunol.
80
232-240
2018
Holothuria leucospilota (A0A2I6STS0), Holothuria leucospilota
Manually annotated by BRENDA team
Watanabe, C.; Shu, G.L.; Giltiay, N.V.; Clark, E.A.
Regulation of B-lineage cells by caspase 6
Immunol. Cell Biol.
96
1072-1082
2018
Mus musculus (O08738)
Manually annotated by BRENDA team
Yao, Y.; Shi, Q.; Chen, B.; Wang, Q.; Li, X.; Li, L.; Huang, Y.; Ji, J.; Shen, P.
Identification of caspase-6 as a new regulator of alternatively activated macrophages
J. Biol. Chem.
291
17450-17466
2016
Mus musculus (O08738)
Manually annotated by BRENDA team
MacPherson, D.J.; Mills, C.L.; Ondrechen, M.J.; Hardy, J.A.
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis
J. Biol. Chem.
294
71-88
2019
Homo sapiens (P55212)
Manually annotated by BRENDA team
Woo, V.; Cheng, C.; Duraikannu, A.; Chandrasekhar, A.; Purdy, K.; Martinez, J.A.; Zochodne, D.W.
Caspase-6 is a dispensable enabler of adult mammalian axonal degeneration
Neuroscience
371
242-253
2018
Mus musculus (O08738)
Manually annotated by BRENDA team
Waldron-Roby, E.; Hoerauf, J.; Arbez, N.; Zhu, S.; Kulcsar, K.; Ross, C.A.
Sox11 reduces caspase-6 cleavage and activity
PLoS ONE
10
e0141439
2015
Homo sapiens (P55212)
Manually annotated by BRENDA team
Bartel, A.; Goehler, A.; Hopf, V.; Breitbach, K.
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines
PLoS ONE
12
e0180203
2017
Mus musculus (O08738), Mus musculus
Manually annotated by BRENDA team
Tubeleviciute-Aydin, A.; Beautrait, A.; Lynham, J.; Sharma, G.; Gorelik, A.; Deny, L.J.; Soya, N.; Lukacs, G.L.; Nagar, B.; Marinier, A.; LeBlanc, A.C.
Identification of allosteric inhibitors against active caspase-6
Sci. Rep.
9
5504
2019
Homo sapiens (P55212), Homo sapiens
Manually annotated by BRENDA team