Protein Variants | Comment | Organism |
---|---|---|
C163A | the catalytic mutant is unabble to self-activate | Mus musculus |
C163A | the catalytic mutant is unable to self-activate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-VAD-fluoromethylketone | - |
Homo sapiens | |
Z-VAD-fluoromethylketone | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
actinin-4 + H2O | Mus musculus | - |
? | - |
? | |
actinin-4 + H2O | Homo sapiens | - |
? | - |
? | |
alpha-tubulin + H2O | Mus musculus | cleaved at Asp438 | ? | - |
? | |
alpha-tubulin + H2O | Homo sapiens | cleaved at Asp438 | ? | - |
? | |
amyloid precursor protein + H2O | Mus musculus | - |
? | - |
? | |
amyloid precursor protein + H2O | Homo sapiens | - |
? | - |
? | |
drebrin + H2O | Mus musculus | - |
? | - |
? | |
drebrin + H2O | Homo sapiens | - |
? | - |
? | |
p97 + H2O | Mus musculus | the main cleavage site is at VAPD179 | ? | - |
? | |
p97 + H2O | Homo sapiens | the main cleavage site is at VAPD179 | ? | - |
? | |
pro-caspase-6 + H2O | Mus musculus | the enzyme can self-process and self-activate | caspase-6 + ? | - |
? | |
pro-caspase-6 + H2O | Homo sapiens | the enzyme can self-process and self-activate | caspase-6 + ? | - |
? | |
spinophilin + H2O | Mus musculus | - |
? | - |
? | |
spinophilin + H2O | Homo sapiens | - |
? | - |
? | |
tau protein + H2O | Mus musculus | cleaved at Asp402 | ? | - |
? | |
tau protein + H2O | Homo sapiens | cleaved at Asp402 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55212 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
dendritic cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
actinin-4 + H2O | - |
Mus musculus | ? | - |
? | |
actinin-4 + H2O | - |
Homo sapiens | ? | - |
? | |
alpha-tubulin + H2O | cleaved at Asp438 | Mus musculus | ? | - |
? | |
alpha-tubulin + H2O | cleaved at Asp438 | Homo sapiens | ? | - |
? | |
amyloid precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
drebrin + H2O | - |
Mus musculus | ? | - |
? | |
drebrin + H2O | - |
Homo sapiens | ? | - |
? | |
p97 + H2O | the main cleavage site is at VAPD179 | Mus musculus | ? | - |
? | |
p97 + H2O | the main cleavage site is at VAPD179 | Homo sapiens | ? | - |
? | |
pro-caspase-6 + H2O | the enzyme can self-process and self-activate | Mus musculus | caspase-6 + ? | - |
? | |
pro-caspase-6 + H2O | the enzyme can self-process and self-activate | Homo sapiens | caspase-6 + ? | - |
? | |
spinophilin + H2O | - |
Mus musculus | ? | - |
? | |
spinophilin + H2O | - |
Homo sapiens | ? | - |
? | |
tau protein + H2O | cleaved at Asp402 | Mus musculus | ? | - |
? | |
tau protein + H2O | cleaved at Asp402 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Casp6 | - |
Mus musculus |
Casp6 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | caspase-6 mRNA levels decrease 3fold in the brains of adult mice exposed to an enriched environment | down |
Mus musculus | caspase-6 mRNA levels increase 2-3fold in the aging mouse cortex and hypothalamus | up |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase-6 activity is intimately associated with the pathologies of Alzheimer's disease. The enzyme is already highly abundant at the beginning of the symptomatic phase of the disease. Caspase-6 activation is necessary for increased amyloid beta levels in serum-deprived primary human neurons. Caspase cleavage of tau protein impairs microtubule polymerization and stability, and may lead to tangle formation. The enzyme also plays a role in axonal degeneration of both peripheral and central nervous system | Homo sapiens |