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Literature summary for 3.4.22.59 extracted from

  • Baburamani, A.A.; Miyakuni, Y.; Vontell, R.; Supramaniam, V.G.; Svedin, P.; Rutherford, M.; Gressens, P.; Mallard, C.; Takeda, S.; Thornton, C.; Hagberg, H.
    Does caspase-6 have a role in perinatal brain injury? (2015), Dev. Neurosci., 37, 321-337.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.59

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-valinamide
-
 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-valinamide
-
 Mus musculus
Q-VD-OPH
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q3TPJ9
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
brain
-
 Mus musculus
-
microglia
-
 Rattus norvegicus
-
microglia
-
 Mus musculus
-
white matter
-
 Rattus norvegicus
-
white matter
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
Casp6
-
 Homo sapiens
Casp6
-
 Rattus norvegicus
Casp6
-
 Mus musculus

General Information

General Information Comment Organism
malfunction gene deletion of caspase-6 did not affect the outcome of brain injury following mild (50 min) or severe (60 min) hypoxia-ischaemia Homo sapiens
malfunction gene deletion of caspase-6 did not affect the outcome of brain injury following mild (50 min) or severe (60 min) hypoxia-ischaemia Rattus norvegicus
malfunction gene deletion of caspase-6 did not affect the outcome of brain injury following mild (50 min) or severe (60 min) hypoxia-ischaemia Mus musculus
physiological function the impact of caspase-6 on the developing brain is subtle and the enzyme is not essential for the cell death processes in the immature brain Homo sapiens
physiological function the impact of caspase-6 on the developing brain is subtle and the enzyme is not essential for the cell death processes in the immature brain Rattus norvegicus
physiological function the impact of caspase-6 on the developing brain is subtle and the enzyme is not essential for the cell death processes in the immature brain Mus musculus