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Literature summary for 3.4.22.59 extracted from

  • Chan, J.Y.; Phoo, M.S.; Clement, M.V.; Pervaiz, S.; Lee, S.C.
    Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53 (2008), Cancer Biol. Ther., 7, 1305-1312.
    View publication on PubMed
Search for more literature for 3.4.22.59

Activating Compound

Activating Compound Comment Organism Structure
resveratrol activates caspase-6, and interacts in a synergistic manner with 5-fluorouracil. In p53-deficient cells it activates 5-fluorouracil-induced apoptosis and caspase-6 activity at low and high doses, while in P53 containing cells, it inhibits the activations at low concentrations, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens resveratrol-mediated activation of caspase-6 leads to apoptosis in HCT-116 colon cancer cells involving also p53, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-6 is activated by cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell line
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 Homo sapiens
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HCT-116 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information resveratrol-mediated activation of caspase-6 leads to apoptosis in HCT-116 colon cancer cells involving also p53, overview Homo sapiens ?
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 ?
VEID-7-amido-4-trifluoromethylcoumarin + H2O
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 Homo sapiens VEID + 7-amino-4-trifluoromethylcoumarin
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 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens