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Literature summary for 3.4.22.59 extracted from

  • Graham, R.K.; Ehrnhoefer, D.E.; Hayden, M.R.
    Caspase-6 and neurodegeneration (2011), Trends Neurosci., 34, 646-656.
    View publication on PubMed
Search for more literature for 3.4.22.59

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of CASP6 in response to ischemia-induced injury. Activation by proteolytic self-cleavage, during activation, the N-terminal prodomain is removed by cleavage at a TETD site. Double cleavage in an unstructured linker region at a DVVD and a TEVD site gives rise to a large 20-kDa and a small 10-kDa subunit. The two large p20 and two small p10 subunits then assemble to form the active CASP6 complex Homo sapiens

Application

Application Comment Organism
drug development selective inhibitors of caspase-6 may have therapeutic potential for various neurodegenerative disorders Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 2 * 34000, isozyme pro-caspase-6alpha, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CBP + H2O Homo sapiens
-
 ?
-
 ?
NF-kappaB + H2O Homo sapiens
-
 ?
-
 ?
pro-caspase-2 + H2O Homo sapiens
-
 caspase-2 + ?
-
 ?
pro-caspase-3 + H2O Homo sapiens
-
 caspase-3 + ?
-
 ?
pro-caspase-8 + H2O Homo sapiens
-
 caspase-8 + ?
-
 ?
tau protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation by proteolytic self-cleavage, during activation, the N-terminal prodomain is removed by cleavage at a TETD site. Double cleavage in an unstructured linker region at a DVVD and a TEVD site gives rise to a large 20-kDa and a small 10-kDa subunit. The two large p20 and two small p10 subunits then assemble to form the active CASP6 complex Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain caspase-6 is elevated in Huntington disease brain, active caspase-6 is present in post mortem brains of Huntington and Alzheimer disease subjects that do not yet display apoptotic morphology Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CBP + H2O
-
 Homo sapiens ?
-
 ?
CBP + H2O i.e. cAMP response element binding binding protein Homo sapiens ?
-
 ?
NF-kappaB + H2O
-
 Homo sapiens ?
-
 ?
pro-caspase-2 + H2O
-
 Homo sapiens caspase-2 + ?
-
 ?
pro-caspase-3 + H2O
-
 Homo sapiens caspase-3 + ?
-
 ?
pro-caspase-8 + H2O
-
 Homo sapiens caspase-8 + ?
-
 ?
tau protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 34000, isozyme pro-caspase-6alpha, SDS-PAGE Homo sapiens
More activation by proteolytic self-cleavage, during activation, the N-terminal prodomain is removed by cleavage at a TETD site. Double cleavage in an unstructured linker region at a DVVD and a TEVD site gives rise to a large 20-kDa and a small 10-kDa subunit. The two large p20 and two small p10 subunits then assemble to form the active CASP6 complex Homo sapiens

Synonyms

Synonyms Comment Organism
Casp6
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function caspase-6 is an end-stage executioner caspase with an important role in nuclear apoptosis by cleaving the nuclear structural protein NuMA and the lamin proteins, which induces nuclear shrinkage and fragmentation. Roles for CASP6 in neurodegenerative diseases, including Huntington disease and Alzheimer disease, signaling pathway leading to activation of caspases and neurodegeneration in Huntington disease, overview. Caspase cleavage of proteins involved in autophagic pathways also occurs and may contribute to the reduction in protein clearance observed in some neurodegenerative diseases. Caspase-6 cleaves also caspases-2, 3 and 8. Role of caspase-6 in neurodegeneration, overview. Activation of CASP6 as a crucial step in the pathogenesis of stroke, activation of CASP6 in response to ischemia-induced injury Homo sapiens