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3.4.22.59: caspase-6

This is an abbreviated version!
For detailed information about caspase-6, go to the full flat file.

Word Map on EC 3.4.22.59

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-/- =

Synonyms

apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, HLcaspase-6, MCH2, Pfcasp-6, VEIDase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.59 caspase-6

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.59 - caspase-6

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O
Ac-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
?
actin + H2O
?
show the reaction diagram
-
-
-
?
actinin-4 + H2O
?
show the reaction diagram
alpha-actinin-4 + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-drebrin + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-spinophilin + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-tubulin + H2O
?
show the reaction diagram
amyloid precursor protein + H2O
?
show the reaction diagram
annexin V + H2O
?
show the reaction diagram
-
-
-
-
?
beta-actin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-catenin + H2O
?
show the reaction diagram
-
processing of beta-catenin, production of a 70000 Da fragment
-
-
?
capping protein alpha + H2O
?
show the reaction diagram
-
-
-
-
?
caspase-8 + H2O
?
show the reaction diagram
-
caspase-6 cleaves, but does not activate caspase-8
-
-
?
CBP + H2O
?
show the reaction diagram
-
-
-
-
?
cofilin I + H2O
?
show the reaction diagram
-
-
-
-
?
cyclin B1 + H2O
truncated cyclin B1 + ?
show the reaction diagram
-
overriding the G2 DNA damage checkpoint permits precocious entry into mitosis that ultimately leads to mitotic catastrophe, caused by caffeine. Mitotic catastrophe is manifested by an unscheduled activation of CDK1, caspase activation and apoptotic cell death. Cyclin B1 is required for mitotic catastrophe, but is also cleaved into a 35 kDa protein by a caspase-dependent mechanism during the process, overview
expression of the truncated product enhanced cell death
-
?
drebrin + H2O
?
show the reaction diagram
eukaryotic elongation factor 1 + H2O
?
show the reaction diagram
-
-
-
-
?
ezrin + H2O
?
show the reaction diagram
GEP100 + H2O
?
show the reaction diagram
-
-
-
?
glial fibrillary acidic protein + H2O
?
show the reaction diagram
-
-
-
-
?
glyceraldehyde-3-phosphate dehydrogenase + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein gp96 precursor + H2O
?
show the reaction diagram
-
-
-
-
?
herpesvirus associated ubiquitin-specific protease + H2O
?
show the reaction diagram
-
-
-
?
Hsp90alpha + H2O
?
show the reaction diagram
-
-
-
-
?
human telomerase + H2O
?
show the reaction diagram
-
caspase-6 cleaves human telomerase, hTERT, during apoptosis in cultured cells
-
-
?
huntingtin + H2O
?
show the reaction diagram
huntingtin + H2O
huntingtin peptide fragments
show the reaction diagram
-
a key step in the onset of Huntington’s disease is the caspase-6 mediated cleavage of the protein huntingtin into toxic fragments
-
-
?
inhibitor-2 of protein phosphatase 2A + H2O
?
show the reaction diagram
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-
-
-
?
inorganic pyrophosphatase + H2O
?
show the reaction diagram
-
-
-
-
?
kinesin5B + H2O
?
show the reaction diagram
-
-
-
?
lamin A + H2O
?
show the reaction diagram
lamin A/C + H2O
?
show the reaction diagram
lamin c + H2O
?
show the reaction diagram
neurolysin + H2O
?
show the reaction diagram
-
-
-
-
?
NF-kappaB + H2O
?
show the reaction diagram
-
-
-
-
?
p97 + H2O
?
show the reaction diagram
PARP + H2O
?
show the reaction diagram
-
-
-
-
?
partitioning-defective 3-like protein splice variant c + H2O
?
show the reaction diagram
-
-
-
?
periplakin + H2O
?
show the reaction diagram
-
caspase 6 has a specific epidermal target which is periplakin
-
-
?
poly(ADP-ribose)polymerase + H2O
?
show the reaction diagram
the enzyme may participate in poly(ADP-ribose)polymerase cleavage observed during apoptosis
-
-
?
pro-caspase-2 + H2O
caspase-2 + ?
show the reaction diagram
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-
-
-
?
pro-caspase-3 + H2O
caspase-3 + ?
show the reaction diagram
-
-
-
-
?
pro-caspase-6 + H2O
?
show the reaction diagram
-
caspase-8 activates caspase-3, and caspase-3 in turn activates caspase-6. Caspase 3 has a major role in nuclear apoptosis
-
-
?
pro-caspase-6 + H2O
caspase-6 + ?
show the reaction diagram
pro-caspase-8 + H2O
?
show the reaction diagram
-
caspase-6 is the major activator of caspase-8 in the cytochrome c-induced apoptosis pathway. Caspase-8 precursor is initially cleaved between the p18 and p10 domains resulting in fragments of 42000 Da and 10000 Da. The 42000 Da fragment is further cleaved resulting in fragments of 25000 Da and 18000 Da
-
-
?
pro-caspase-8 + H2O
caspase-8 + ?
show the reaction diagram
-
-
-
-
?
procaspase-3 + H2O
caspase-3 + ?
show the reaction diagram
procaspase-8 + H2O
caspase-8 + ?
show the reaction diagram
prolyl endopeptidase + H2O
?
show the reaction diagram
-
-
-
-
?
protein 14-3-3epsilon + H2O
?
show the reaction diagram
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-
-
-
?
protein 14-3-3zeta + H2O
?
show the reaction diagram
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-
-
-
?
Rab GDP dissociation factor inhibitor alpha + H2O
?
show the reaction diagram
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-
-
-
?
receptor-interacting protein kinase-1 + H2O
?
show the reaction diagram
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-
?
SATB1 + H2O
?
show the reaction diagram
-
cleavage disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis
-
-
?
serologically defined colon cancer antigen 3 + H2O
?
show the reaction diagram
-
-
-
?
spinophilin + H2O
?
show the reaction diagram
tau protein + H2O
?
show the reaction diagram
transcription factor AP-2alpha + H2O
?
show the reaction diagram
tubulin + H2O
?
show the reaction diagram
-
-
-
?
Ufd2p + H2O
?
show the reaction diagram
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cleavage of polyubiquitination factor Ufd2p at Asp123 within the putative regulatory N-terminal domain might have important functional consequences within the apoptotic cascade
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?
valosin-containing protein + H2O
?
show the reaction diagram
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-
-
-
?
vimentin + H2O
?
show the reaction diagram
-
-
-
?
viral nucleocapsid protein of transmissible gastroenteritis coronovirus + H2O
?
show the reaction diagram
-
cleavage site VVPD359-/-. Destruction of viral protein by the host cell death machinery
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?
additional information
?
-