3.4.22.59: caspase-6
This is an abbreviated version!
For detailed information about caspase-6, go to the full flat file.
Word Map on EC 3.4.22.59
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3.4.22.59
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caspases
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bcl-2
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alzheimer
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neurodegenerative
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pro-apoptotic
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huntington
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lamins
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apoptosis-related
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parp
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executioner
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caspase-dependent
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anti-apoptotic
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polyadp-ribose
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tunel
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caspase-mediated
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casps
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jurkat
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bid
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pan-caspase
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zvad-fmk
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apaf-1
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medicine
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procaspase-3
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fadd
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diagnostics
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fas-associated
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drug development
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molecular biology
- 3.4.22.59
-
caspases
- bcl-2
- alzheimer
- neurodegenerative
-
pro-apoptotic
- huntington
- lamins
-
apoptosis-related
- parp
-
executioner
-
caspase-dependent
-
anti-apoptotic
-
polyadp-ribose
-
tunel
-
caspase-mediated
-
casps
-
jurkat
- bid
-
pan-caspase
- zvad-fmk
- apaf-1
- medicine
- procaspase-3
- fadd
- diagnostics
-
fas-associated
- drug development
- molecular biology
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-/- =
Synonyms
apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, HLcaspase-6, MCH2, Pfcasp-6, VEIDase
ECTree
3.4.22.59 caspase-6Advanced search results
results (
results (Activating Compound
Activating Compound on EC 3.4.22.59 - caspase-6
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
adriamycin
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increases caspase-6 mRNA levels in HCT116 p53+ and neo cells but not in E6 cells
RCasp1
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mediates increased self-processing of pro-Casp6a into its active subunits
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Tumor necrosis factor alpha
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activates caspase-6 which in turn cleaves transcription factor AP2alpha
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resveratrol
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activates caspase-6, and interacts in a synergistic manner with 5-fluorouracil. In p53-deficient cells it activates 5-fluorouracil-induced apoptosis and caspase-6 activity at low and high doses, while in P53 containing cells, it inhibits the activations at low concentrations, overview
additional information
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caspase-6 can be entirely self-activated through self-processing, the prodomain of Casp6 entirely prevents self-processing and activation in vivo but not in vitro, removal of the pro-domain promotes Casp6 activation
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additional information
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glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9
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additional information
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ZBP-89, a Kruppel-type, zinc finger transcription factor, induces caspase-6 activation leading to inhibition of cell death in hepatoccellular carcinoma cells, inhibition of caspase-6 abolishes the effect of ZBP-89
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additional information
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activation of CASP6 in response to ischemia-induced injury. Activation by proteolytic self-cleavage, during activation, the N-terminal prodomain is removed by cleavage at a TETD site. Double cleavage in an unstructured linker region at a DVVD and a TEVD site gives rise to a large 20-kDa and a small 10-kDa subunit. The two large p20 and two small p10 subunits then assemble to form the active CASP6 complex
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additional information
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cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6
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additional information
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glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9
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