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Literature summary for 3.4.22.59 extracted from

  • Shahzidi, S.; Brech, A.; Sioud, M.; Li, X.; Suo, Z.; Nesland, J.M.; Peng, Q.
    Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells (2013), Cancer Lett., 339, 25-32.
    View publication on PubMed
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Application

Application Comment Organism
medicine lamin A/C cleavage by caspase-6 is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-valinamide pan-caspase inhibitor Homo sapiens
Z-VE(OMe)ID(OMe)-fluoromethylketone specific inhibitor Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15000
-
 x * 15000, cleaved enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lamin A/C + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DAUDI cell B-cell lymphoma cell line Homo sapiens
-
Ramos cell B-cell lymphoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lamin A/C + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 15000, cleaved enzyme, SDS-PAGE Homo sapiens