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Literature summary for 3.4.22.59 extracted from

  • Gafni, J.; Papanikolaou, T.; Degiacomo, F.; Holcomb, J.; Chen, S.; Menalled, L.; Kudwa, A.; Fitzpatrick, J.; Miller, S.; Ramboz, S.; Tuunanen, P.I.; Lehtimaeki, K.K.; Yang, X.W.; Park, L.; Kwak, S.; Howland, D.; Park, H.; Ellerby, L.M.
    Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment (2012), J. Neurosci., 32, 7454-7465.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 x * 32000, pro-enzyme, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
huntingtin + H2O Mus musculus the enzyme cleaves at Asp-586 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
 Mus musculus
-
striatum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
huntingtin + H2O the enzyme cleaves at Asp-586 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 32000, pro-enzyme, SDS-PAGE Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme plays a role in clearance pathways for the huntingtin protein whose proteolysis is a critical pathological event in Huntington's diesease Mus musculus