Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbobenzyloxy-VAD-fluoromethyl ketone | i.e. zVAD-fmk, a broad-spectrum caspase inhibitor, which inhibits activation of caspase-6 and caspase-3, but not of caspase-7 | Homo sapiens | |
additional information | carbobenzyloxy-LEHD-fluoromethyl ketone specifically inhibits initiator caspase-9 upstream of caspase-3 and caspase-3 activation, but fails to inhibit caspase-6 and caspase-7 activation | Homo sapiens | |
SB203580 | a p38 inhibitor, also inhibits activation of caspase-6, caspase-3, and caspase-7 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells, caspase-6 is responsible for DNA ladder formation durirng hypoxia, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | HUVECs are isolated from human umbilical cord | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells, caspase-6 is responsible for DNA ladder formation durirng hypoxia, overview | Homo sapiens | ? | - |
? |