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Literature summary for 3.4.22.59 extracted from

  • MacLachlan, T.K.; El-Deiry, W.S.
    Apoptotic threshold is lowered by p53 transactivation of caspase-6 (2002), Proc. Natl. Acad. Sci. USA, 99, 9492-9497.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.59

Activating Compound

Activating Compound Comment Organism Structure
adriamycin increases caspase-6 mRNA levels in HCT116 p53+ and neo cells but not in E6 cells Homo sapiens
etoposide mild induction of the enzyme in HCT116 p53+ cells Homo sapiens
P53
-
 Homo sapiens

Application

Application Comment Organism
medicine caspase-6 is upregulated in response to p53 overexpression, induction of caspase-6 expression lowers the cell death threshold in response to apoptotic signals that activate caspase-6, potential mechanism of lowering the death threshold, which could be important for chemosensitization Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DMSO
-
 Homo sapiens
VEID-FMK
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DLD-1 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
additional information p53 up-regulates caspase -6mRNA in H460, H460-neo, H460-E6, HCT16-neo, HCT16-E6, HCT16-P53-, SKBR3, U2OS, M3, HCC1937 and SW13 cell lines, MCF7 cells fail to show induction of caspase 6-mRNA Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lamin A + H2O
-
 Homo sapiens ?
-
 ?