3.4.22.59: caspase-6
This is an abbreviated version!
For detailed information about caspase-6, go to the full flat file.
Word Map on EC 3.4.22.59
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3.4.22.59
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caspases
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bcl-2
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alzheimer
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neurodegenerative
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pro-apoptotic
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huntington
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lamins
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apoptosis-related
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parp
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executioner
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caspase-dependent
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anti-apoptotic
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polyadp-ribose
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tunel
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caspase-mediated
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casps
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jurkat
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bid
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pan-caspase
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zvad-fmk
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apaf-1
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medicine
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procaspase-3
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fadd
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diagnostics
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fas-associated
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drug development
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molecular biology
- 3.4.22.59
-
caspases
- bcl-2
- alzheimer
- neurodegenerative
-
pro-apoptotic
- huntington
- lamins
-
apoptosis-related
- parp
-
executioner
-
caspase-dependent
-
anti-apoptotic
-
polyadp-ribose
-
tunel
-
caspase-mediated
-
casps
-
jurkat
- bid
-
pan-caspase
- zvad-fmk
- apaf-1
- medicine
- procaspase-3
- fadd
- diagnostics
-
fas-associated
- drug development
- molecular biology
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-/- =
Synonyms
apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, HLcaspase-6, MCH2, Pfcasp-6, VEIDase
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diagnostics
drug development
medicine
molecular biology
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excessive activation of caspase-6 is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment
diagnostics
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excessive activation of caspase-6 is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment
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selective inhibitors of caspase-6 may have therapeutic potential for various neurodegenerative disorders
drug development
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the enzyme is a target for therapeutic intervention in Alzheimer's and Huntington's diseases
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caspase 6 expression remains elevated long after the occurrence of acute cell death during epileptogenesis and epilepsy, indicating that the enzyme has functions other than execution of programmed cell death in epileptogenic hippocampus
medicine
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caspase-6 is active early in the pathogenesis of Alzheimer´s disease, the enzyme is strongly implicated in human neuronal degeneration and apoptosis, its inhibition may be an efficient treatment
medicine
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caspase-6 is phosphorylated by AMP-activated protein kinase related kinase 5 at Ser257 in colorectal cancer cells, leading to inactivation of caspase-6 and resulting in resistance to cell death via cFLIPs protection and leading to resistance to the FAS ligand/Fas system
medicine
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caspase-6 is upregulated in response to p53 overexpression, induction of caspase-6 expression lowers the cell death threshold in response to apoptotic signals that activate caspase-6, potential mechanism of lowering the death threshold, which could be important for chemosensitization
medicine
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critical role of caspase-6 and its cleavage of lamin A in apoptotic signaling triggered by resveratrol in the colon carcinoma cells
medicine
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difference between normal fiber cell differentation and apoptosis and the capacity of the lens to differentially regulate these two processes
medicine
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difference between normal fiber cell differentation and apoptosis and the capacity of the lens to differentially regulate these two processes
medicine
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role for caspase-6 and N-terminal truncation of tau during neurovibrillary tangle evolution and the progression of Alzheimer´s disease
medicine
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Streptococcus pneumoniae induces apoptosis of human alveolar and bronchial epithelial cells, programmed cell death is excecuted by caspase 6, and can be blocked by overexpression of Bcl2
medicine
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the loss of caspase-6 does not appear to impair the ability of any anticancer agents to induce apoptosis
medicine
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compared to caspase-3 there is a siginificant correlation between caspase-6 protein and necrosis and proliferation index of the analysed tumors
medicine
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lamin A/C cleavage by caspase-6 is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
medicine
caspase-6 inhibition is a promising strategy to stop early stage neurodegenerative events
medicine
caspase-6 might be a key nod molecule to regulate immunological steady-state and be a therapeutic candidate for tumor immunotherapy
heat sensitive expression of caspase-6 in the embryonic heart is of interest since cardiac malformations are an emergent problem in salmon aquaculture
molecular biology
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it is shown that caspase-6 is the major caspase responsible for the death of cells infected with Adeno-associated virus (AAV) infection
molecular biology
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it is shown that trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6
molecular biology
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the results show that caspase-1 is an upstream positive regulator of caspase-6-mediated cell death in primary human neurons