Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 | Mus musculus |
Application | Comment | Organism |
---|---|---|
diagnostics | excessive activation of caspase-6 is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | endogenous caspase-6 zymogen is cytoplasmic and nuclear | Mus musculus | 5737 | - |
additional information | cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 | Mus musculus | - |
- |
nucleus | endogenous caspase-6 zymogen is cytoplasmic and nuclear | Mus musculus | 5634 | - |
perinuclear space | caspase-6 is distinctly co-localized with gamma-tubulin | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
huntingtin + H2O | Mus musculus | cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview | ? | - |
? | |
huntingtin + H2O | Mus musculus YAC128 | cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview | ? | - |
? | |
additional information | Mus musculus | caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment | ? | - |
? | |
additional information | Mus musculus YAC128 | caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
YAC128 mice | - |
Mus musculus YAC128 | - |
YAC128 mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | - |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
corpus striatum | - |
Mus musculus | - |
neuron | striatal, primary | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
huntingtin + H2O | cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview | Mus musculus | ? | - |
? | |
huntingtin + H2O | cleavage at the capase-6 consensus sequence at amino acid 586, a position 586 mutant of huntingtin is not cleaved by caspase-6, mutational caspase cleavage site analysis of huntingtin, overview | Mus musculus | ? | - |
? | |
huntingtin + H2O | cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview | Mus musculus YAC128 | ? | - |
? | |
huntingtin + H2O | cleavage at the capase-6 consensus sequence at amino acid 586, a position 586 mutant of huntingtin is not cleaved by caspase-6, mutational caspase cleavage site analysis of huntingtin, overview | Mus musculus YAC128 | ? | - |
? | |
additional information | caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment | Mus musculus | ? | - |
? | |
additional information | caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment | Mus musculus YAC128 | ? | - |
? | |
VEID-7-amido-4-trifluoromethylcoumarin + H2O | - |
Mus musculus | VEID + 7-amino-4-trifluoromethylcoumarin | - |
? | |
VEID-7-amido-4-trifluoromethylcoumarin + H2O | - |
Mus musculus YAC128 | VEID + 7-amino-4-trifluoromethylcoumarin | - |
? |