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Literature summary for 3.4.22.59 extracted from

  • Warby, S.C.; Doty, C.N.; Graham, R.K.; Carroll, J.B.; Yang, Y.Z.; Singaraja, R.R.; Overall, C.M.; Hayden, M.R.
    Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus (2008), Hum. Mol. Genet., 17, 2390-2404.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 Mus musculus

Application

Application Comment Organism
diagnostics excessive activation of caspase-6 is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm endogenous caspase-6 zymogen is cytoplasmic and nuclear Mus musculus 5737
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additional information cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 Mus musculus
-
-
nucleus endogenous caspase-6 zymogen is cytoplasmic and nuclear Mus musculus 5634
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perinuclear space caspase-6 is distinctly co-localized with gamma-tubulin Mus musculus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
huntingtin + H2O Mus musculus cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview ?
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?
huntingtin + H2O Mus musculus YAC128 cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview ?
-
?
additional information Mus musculus caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment ?
-
?
additional information Mus musculus YAC128 caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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YAC128 mice
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Mus musculus YAC128
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YAC128 mice
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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corpus striatum
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Mus musculus
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neuron striatal, primary Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
huntingtin + H2O cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview Mus musculus ?
-
?
huntingtin + H2O cleavage at the capase-6 consensus sequence at amino acid 586, a position 586 mutant of huntingtin is not cleaved by caspase-6, mutational caspase cleavage site analysis of huntingtin, overview Mus musculus ?
-
?
huntingtin + H2O cleavage at the capase-6 consensus sequence at amino acid 586 in the nucleus, proteolysis of mutant huntingtin is crucial to the development of Huntington disease. Cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 and increased cleavage of huntingtin, overview. Differential localization of different endogenous caspase-cleaved huntingtin fragments in perinuclear and nuclear regions, overview Mus musculus YAC128 ?
-
?
huntingtin + H2O cleavage at the capase-6 consensus sequence at amino acid 586, a position 586 mutant of huntingtin is not cleaved by caspase-6, mutational caspase cleavage site analysis of huntingtin, overview Mus musculus YAC128 ?
-
?
additional information caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment Mus musculus ?
-
?
additional information caspase-6 is a key caspase known to play both initiator and effector roles in programmed cell death, excessive activation of the enzyme is an early marker of neuronal dysfunction and implicated in the pathogenesis of Huntington disease, Alzheimer's disease and other forms of cognitive impairment Mus musculus YAC128 ?
-
?
VEID-7-amido-4-trifluoromethylcoumarin + H2O
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Mus musculus VEID + 7-amino-4-trifluoromethylcoumarin
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?
VEID-7-amido-4-trifluoromethylcoumarin + H2O
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Mus musculus YAC128 VEID + 7-amino-4-trifluoromethylcoumarin
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?