Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-VEID-CHO | a caspase-6-specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclin B1 + H2O | Homo sapiens | overriding the G2 DNA damage checkpoint permits precocious entry into mitosis that ultimately leads to mitotic catastrophe, caused by caffeine. Mitotic catastrophe is manifested by an unscheduled activation of CDK1, caspase activation and apoptotic cell death. Cyclin B1 is required for mitotic catastrophe, but is also cleaved into a 35 kDa protein by a caspase-dependent mechanism during the process, overview | truncated cyclin B1 + ? | expression of the truncated product enhanced cell death | ? | |
lamin A + H2O | Homo sapiens | specific cleavage by caspase-6 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation through cleavage mainly by caspase-8, partly by caspase-2 and caspase-9 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclin B1 + H2O | overriding the G2 DNA damage checkpoint permits precocious entry into mitosis that ultimately leads to mitotic catastrophe, caused by caffeine. Mitotic catastrophe is manifested by an unscheduled activation of CDK1, caspase activation and apoptotic cell death. Cyclin B1 is required for mitotic catastrophe, but is also cleaved into a 35 kDa protein by a caspase-dependent mechanism during the process, overview | Homo sapiens | truncated cyclin B1 + ? | expression of the truncated product enhanced cell death | ? | |
cyclin B1 + H2O | cleavage occurs after Asp123 in the motif ILVD123k, mutation of this motif to D123N attenuates the cleavage, cleavage still occurred in the control D160N mutant | Homo sapiens | truncated cyclin B1 + ? | lacking part of the NH2-terminal regulatory domain including the destruction box sequence | ? | |
lamin A + H2O | specific cleavage by caspase-6 | Homo sapiens | ? | - |
? | |
poly(ADP-ribose) polymerase + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | cyclin B1 migrates anomalously on SDS-PAGE with 48 kDa predicted size versus 67 kDa experimental size | Homo sapiens |