3.4.22.59: caspase-6
This is an abbreviated version!
For detailed information about caspase-6, go to the full flat file.
Word Map on EC 3.4.22.59
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3.4.22.59
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caspases
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bcl-2
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alzheimer
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neurodegenerative
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pro-apoptotic
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huntington
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lamins
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apoptosis-related
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parp
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executioner
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caspase-dependent
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anti-apoptotic
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polyadp-ribose
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tunel
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caspase-mediated
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casps
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jurkat
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bid
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pan-caspase
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zvad-fmk
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apaf-1
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medicine
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procaspase-3
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fadd
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diagnostics
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fas-associated
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drug development
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molecular biology
- 3.4.22.59
-
caspases
- bcl-2
- alzheimer
- neurodegenerative
-
pro-apoptotic
- huntington
- lamins
-
apoptosis-related
- parp
-
executioner
-
caspase-dependent
-
anti-apoptotic
-
polyadp-ribose
-
tunel
-
caspase-mediated
-
casps
-
jurkat
- bid
-
pan-caspase
- zvad-fmk
- apaf-1
- medicine
- procaspase-3
- fadd
- diagnostics
-
fas-associated
- drug development
- molecular biology
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-/- =
Synonyms
apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, HLcaspase-6, MCH2, Pfcasp-6, VEIDase
ECTree
3.4.22.59 caspase-6Advanced search results
results (
results (KM Value
KM Value on EC 3.4.22.59 - caspase-6
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.08
(N-acetyl-VEID)2-rhodamine110
in 50 mM HEPES (pH 7.0), 25 mM MgSO4, 0.5 mM EGTA, 5 mM glutathione, 0.01% (v/v) Triton X-100 containing 0.1% (w/v) bovine gamma-globulin, at 22°C
0.0227
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7.2, mutant enzyme A34E
0.0312
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7., wild-type enzyme
0.0326
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7.2, mutant enzyme K284A
0.0333
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7.2, mutant enzyme T182S
0.0345
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7.2, mutant enzyme A109T
0.0371
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7.2, mutant enzyme E35K
0.315
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin
37°C, pH 7.2, mutant enzyme L200A
0.02371
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin
pH 7.5, 37°C, mutant enzyme R44K
0.0277
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin
pH 7.5, 37°, wild-type enzyme
0.03063
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin
pH 7.5, 37°C, mutant enzyme R42A/R43A/R44A
0.082
N-acetyl-VEID-7-amido-4-methylcoumarin
mutant enzyme E244A, in 100 mM HEPES, pH 7.5, 10% (w/v) sucrose, 0.1% (w/v) CHAPS, 20 mM TCEP, and 120 mM NaCl, at 37°C
0.093
N-acetyl-VEID-7-amido-4-methylcoumarin
wild type enzyme, in 100 mM HEPES, pH 7.5, 10% (w/v) sucrose, 0.1% (w/v) CHAPS, 20 mM TCEP, and 120 mM NaCl, at 37°C
0.109
N-acetyl-VEID-7-amido-4-methylcoumarin
mutant enzyme K36A, in 100 mM HEPES, pH 7.5, 10% (w/v) sucrose, 0.1% (w/v) CHAPS, 20 mM TCEP, and 120 mM NaCl, at 37°C
0.14
N-acetyl-VEID-7-amido-4-methylcoumarin
mutant enzyme H287A, in 100 mM HEPES, pH 7.5, 10% (w/v) sucrose, 0.1% (w/v) CHAPS, 20 mM TCEP, and 120 mM NaCl, at 37°C
0.176
N-acetyl-VEID-7-amido-4-methylcoumarin
mutant enzyme E244A/H287A, in 100 mM HEPES, pH 7.5, 10% (w/v) sucrose, 0.1% (w/v) CHAPS, 20 mM TCEP, and 120 mM NaCl, at 37°C
