EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
pancreatic beta cell |
- |
740804 |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
pancreatic beta cell |
primary |
687573 |
1.1.1.39 | malate dehydrogenase (decarboxylating) |
pancreatic beta cell |
- |
712942 |
1.1.1.39 | malate dehydrogenase (decarboxylating) |
pancreatic beta cell |
isozyme ME2 |
687568 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
pancreatic beta cell |
- |
687652, 710813 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
pancreatic beta cell |
isozymes ME1 and ME3 |
687568 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
pancreatic beta cell |
ME3 enzyme activity is low in beta-cells |
741010 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
pancreatic beta cell |
moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes. The animal show an improved glucose tolerance and insulin sensitivity when compared to old age-matched wild type ones |
761119 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
pancreatic beta cell |
insulin-producing beta-cells and primary islets. Pancreatic beta-cells are endowed with a unique high expression level of GPx4, while GPx4 expression is significantly lower in insulin-producing RINm5F cells |
-, 764207 |
1.11.1.9 | glutathione peroxidase |
pancreatic beta cell |
- |
686738 |
1.14.14.19 | steroid 17alpha-monooxygenase |
pancreatic beta cell |
- |
705395 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
pancreatic beta cell |
- |
713716 |
1.21.99.3 | thyroxine 5-deiodinase |
pancreatic beta cell |
- |
734596 |
1.3.8.1 | short-chain acyl-CoA dehydrogenase |
pancreatic beta cell |
low expression of ACADS during high expression of L-3-hydroxyacyl-CoA dehydrogenase short chain |
687573 |
1.4.1.2 | glutamate dehydrogenase |
pancreatic beta cell |
- |
698996 |
1.4.3.4 | monoamine oxidase |
pancreatic beta cell |
- |
655721 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
pancreatic beta cell |
- |
711828, 711856 |
2.3.1.B43 | protein-lysine desuccinylase (NAD+) |
pancreatic beta cell |
- |
756680 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
pancreatic beta cell |
- |
735872 |
2.5.1.46 | deoxyhypusine synthase |
pancreatic beta cell |
- |
-, 721984 |
2.7.1.1 | hexokinase |
pancreatic beta cell |
- |
660810, 663393, 702119, 702140, 702236, 702314, 703358, 703385, 703597, 703624, 703968, 759145 |
2.7.1.137 | phosphatidylinositol 3-kinase |
pancreatic beta cell |
- |
661681 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
pancreatic beta cell |
- |
761780 |
2.7.1.23 | NAD+ kinase |
pancreatic beta cell |
- |
721255 |
2.7.1.4 | fructokinase |
pancreatic beta cell |
- |
674062 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
pancreatic beta cell |
- |
641821 |
2.7.11.1 | non-specific serine/threonine protein kinase |
pancreatic beta cell |
akt expression is increased in dexamethasone-induced beta cell proliferation |
692669 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
pancreatic beta cell |
- |
661046, 721523 |
2.7.11.30 | receptor protein serine/threonine kinase |
pancreatic beta cell |
- |
664721 |
2.7.11.30 | receptor protein serine/threonine kinase |
pancreatic beta cell |
and beta cell lines |
690773 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
pancreatic beta cell |
- |
701620 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
pancreatic beta cell |
- |
760852 |
3.1.1.79 | hormone-sensitive lipase |
pancreatic beta cell |
- |
665562 |
3.1.1.79 | hormone-sensitive lipase |
pancreatic beta cell |
located in close association to insulin granules in beta-cells |
690762 |
3.1.1.79 | hormone-sensitive lipase |
pancreatic beta cell |
the beta-cell isoform of HSL is involved in maintaining lipid homeostasis in islets and contributes to the proper control of glucose stimulated insulin secretion |
679455 |
3.1.3.48 | protein-tyrosine-phosphatase |
pancreatic beta cell |
- |
693383 |
3.1.4.4 | phospholipase D |
pancreatic beta cell |
- |
714923 |
3.4.14.5 | dipeptidyl-peptidase IV |
pancreatic beta cell |
- |
699753 |
3.4.17.10 | carboxypeptidase E |
pancreatic beta cell |
- |
668420, 668816 |
3.4.17.10 | carboxypeptidase E |
pancreatic beta cell |
beta cells lacking the insulin receptor show a decreased expression of CPE. CPE protein expression is up-regulated upon insulin stimulation |
732836 |
3.4.21.61 | Kexin |
pancreatic beta cell |
- |
731241 |
3.4.21.93 | Proprotein convertase 1 |
pancreatic beta cell |
- |
731716 |
3.4.22.61 | caspase-8 |
pancreatic beta cell |
Casp8 is essential for beta-cell apoptosis in type 1 and type 2 diabetes models and in regulating beta-cell mass and insulin secretion under physiological conditions |
679441 |
3.4.22.B30 | calpain 10 |
pancreatic beta cell |
- |
664720 |
3.5.1.23 | ceramidase |
pancreatic beta cell |
- |
752416 |
3.9.1.3 | phosphohistidine phosphatase |
pancreatic beta cell |
- |
735423 |
4.1.1.15 | glutamate decarboxylase |
pancreatic beta cell |
isozyme GAD65 |
697617 |
4.1.1.32 | phosphoenolpyruvate carboxykinase (GTP) |
pancreatic beta cell |
- |
704540 |
4.6.1.1 | adenylate cyclase |
pancreatic beta cell |
- |
693436 |
6.4.1.1 | pyruvate carboxylase |
pancreatic beta cell |
- |
693143 |
6.4.1.1 | pyruvate carboxylase |
pancreatic beta cell |
beta-cells possess compensatory systems that are activated in response to suppression of pyruvate carboxylase nzyme levels. The compensatory events include allosteric activation of pyruvate carboxylase due to increased levels of acetyl-CoA and enhanced conversion of isocitrate to 2-oxoglutarate and downstream metabolites via the cytosolic, NADP-dependent isocitrate dehydrogenase |
674615 |
6.4.1.1 | pyruvate carboxylase |
pancreatic beta cell |
enzyme activity is preserved in the islets of obese animals, but it is reduced in the islets of animal models of type 2 diabetes |
692005 |
6.4.1.2 | acetyl-CoA carboxylase |
pancreatic beta cell |
- |
693050 |
7.2.2.10 | P-type Ca2+ transporter |
pancreatic beta cell |
- |
733277 |
7.2.2.13 | Na+/K+-exchanging ATPase |
pancreatic beta cell |
- |
700591 |
7.6.2.2 | ABC-type xenobiotic transporter |
pancreatic beta cell |
- |
698233 |