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Information on EC 3.1.1.79 - hormone-sensitive lipase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.79 hormone-sensitive lipase
IUBMB Comments
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters , retinyl esters and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond . The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
13-HSL, alpha/beta hydrolase, Blip, cardiac HSL, cold-active hormone-sensitive lipase, Est06, Est22, Est25, EstB, EstE5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
diacylglycerol + H2O = monoacylglycerol + a carboxylate
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monoacylglycerol + H2O = glycerol + a carboxylate
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triacylglycerol + H2O = diacylglycerol + a carboxylate
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PATHWAY SOURCE
PATHWAYS