Literature summary for 3.4.21.93 extracted from

Ozawa, S.; Katsuta, H.; Suzuki, K.; Takahashi, K.; Tanaka, T.; Sumitani, Y.; Nishida, S.; Yoshimoto, K.; Ishida, H.
Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic beta-cells of type 2 diabetic patients (2014), Endocr. J., 61, 607-614.

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Application

Application	Comment	Organism
medicine	prohormone convertase 1/3 activity is significantly lower in type 2 diabetic patients than in the control group. Decreased activity of prohormone convertase 1/3 rather than prohormone convertase 2 in pancreatic beta-cells is involved in the impaired proinsulin processing, resulting in elevated intact proinsulin levels in type 2 diabetic patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29120	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Homo sapiens	-
pancreatic beta cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)