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Literature summary for 2.3.1.B43 extracted from

  • Ma, Y.; Fei, X.
    SIRT5 regulates pancreatic beta-cell proliferation and insulin secretion in type 2 diabetes (2018), Exp. Therap. Med., 16, 1417-1425 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Protein Variants

Protein Variants Comment Organism
additional information SIRT5 ectopic expression downregulates the expression of pancreatic and duodenal homeobox 1 (PDX1) and the inhibition of SIRT5 upregulated PDX1 expression. SIRT5 knockout using small interfering RNA targeting sirtuin 5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [histone H4]-N6-acetyl-L-lysine16 Homo sapiens deacetylation, cf. EC 2.3.1.286 nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information sirtuin 5 (SIRT5) is upregulated in patients with type 2 diabetes and in pancreatic beta cell lines Homo sapiens
-
pancreas
-
 Homo sapiens
-
pancreatic beta cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H4]-N6-acetyl-L-lysine16 deacetylation, cf. EC 2.3.1.286 Homo sapiens nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
-
 Homo sapiens
sirtuin 5
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens sirtuin 5 (SIRT5) is upregulated in patients with type 2 diabetes and in pancreatic beta cell lines up

General Information

General Information Comment Organism
evolution sirtuins (SIRTs) are proteins that possess nicotinxadamide-adenine dinucleotide-dependent deacetylase activity and belong to the histone deacetylase (HDAC) family, which consist of seven different subtypes in mammals (SIRT1-7) Homo sapiens
physiological function sirtuin 5 (SIRT5) is upregulated in patients with type 2 diabetes. Elevated SIRT5 expression is positively associated with age and blood glucose levels, and negatively associated with pancreatic and duodenal homeobox 1 (PDX1) expression. SIRT5 regulates pancreatic beta cell proliferation and insulin secretion in type 2 diabetes. SIRT5 suppresses the proliferation of pancreatic beta cells in vitro. While SIRT5 possesses weak deacetylase activity, it catalyzes the modification of acidic lysine residues by glutaryxadlation, succinylation, and malonylation well. PDX1 is transcriptionally regulated by SIRT5 via H4K16 deacetylation. PDX1 is involved in SIRT5-mediated insulin secretion and pancreatic beta cell proliferation Homo sapiens