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Information on EC 1.1.1.35 - 3-hydroxyacyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.1.1.35

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IUBMB Comments

Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3-hydroxyacyl-hydrolipoate. Some enzymes act, more slowly, with NADP+. Broad specificity to acyl chain-length (cf. EC 1.1.1.211 [long-chain-3-hydroxyacyl-CoA dehydrogenase]).

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
3-hydroxyacyl-coa dehydrogenase, l-3-hydroxyacyl-coa dehydrogenase, beta-hydroxyacyl coa dehydrogenase, hadhsc, 3-hydroxyacyl-coenzyme a dehydrogenase, short-chain 3-hydroxyacyl-coa dehydrogenase, short-chain l-3-hydroxyacyl-coa dehydrogenase, 3-ketoacyl-coa reductase, beta-ketoacyl-coa reductase, 3-hydroxyacyl coenzyme a dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered), 2-methyl-branched fatty acid beta-oxidation, 2-methylpropene degradation, 3-hydroxypropanoate/4-hydroxybutanate cycle, 3-phenylpropanoate degradation, 4-hydroxybenzoate biosynthesis III (plants), adipate biosynthesis, adipate degradation, androstenedione degradation I (aerobic), androstenedione degradation II (anaerobic), benzoate biosynthesis I (CoA-dependent, beta-oxidative), benzoyl-CoA biosynthesis, benzoyl-CoA degradation I (aerobic), cholesterol degradation to androstenedione I (cholesterol oxidase), cholesterol degradation to androstenedione II (cholesterol dehydrogenase), crotonate fermentation (to acetate and cyclohexane carboxylate), fatty acid beta-oxidation I (generic), fatty acid beta-oxidation II (plant peroxisome), fatty acid beta-oxidation VI (mammalian peroxisome), fatty acid salvage, glutaryl-CoA degradation, L-glutamate degradation V (via hydroxyglutarate), methyl ketone biosynthesis (engineered), methyl tert-butyl ether degradation, oleate beta-oxidation, phenylacetate degradation I (aerobic), platensimycin biosynthesis, pyruvate fermentation to butanoate, pyruvate fermentation to butanol I, pyruvate fermentation to butanol II (engineered), pyruvate fermentation to hexanol (engineered), valproate beta-oxidation