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Information on EC 1.14.14.19 - steroid 17alpha-monooxygenase

for references in articles please use BRENDA:EC1.14.14.19

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IUBMB Comments

Requires NADPH and EC 1.6.2.4, NADPH—hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17α-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17α-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32, 17α-hydroxyprogesterone deacetylase). The ratio of the 17α-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.

The enzyme appears in viruses and cellular organisms

Synonyms
17,20-lyase, 17ohd, p450 17, cyp 17, p450(17alpha), cytochrome p450c17alpha, cytochrome p450 17alpha-hydroxylase, 17-hydroxylase/17,20-lyase, 17 alpha-hydroxylase/c17,20-lyase, 17alpha-ohase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 = a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
11-oxyandrogens biosynthesis, androgen biosynthesis, backdoor pathway of androgen biosynthesis, glucocorticoid biosynthesis