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Information on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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IUBMB Comments
Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32, 17alpha-hydroxyprogesterone deacetylase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.
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The enzyme appears in viruses and cellular organisms
Synonyms
17,20-lyase, 17ohd, p450 17, cyp 17, p450(17alpha), cytochrome p450c17alpha, cytochrome p450 17alpha-hydroxylase, 17-hydroxylase/17,20-lyase, 17 alpha-hydroxylase/c17,20-lyase, 17alpha-ohase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 = a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
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