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Information on EC 2.7.1.23 - NAD+ kinase
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2.7.1.23 NAD+ kinaseSpecify your search results
The enzyme appears in viruses and cellular organisms
Synonyms
nad kinase, nadk, nad+ kinase, nadk2, nad(h) kinase, utr1p, osnadk1, slr0400, c5orf33, sll1415, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ATP: NAD(H) 2'-phosphotransferase
ATP:NAD 2'-phosphotransferase
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DPN kinase
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kinase (phosphorylating), nicotinamide adenine dinucleotide
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kinase, nicotinamide adenine dinucleotide (phosphorylating)
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MJ0917
NAD kinase
NAD kinase 1
NAD(H) kinase
NADHK
NADK
NADK1
NADK2
nicotinamide adenine dinucleotide kinase
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PH1074
Poly(P)/ATP NAD kinase
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poly(P)/ATP-NAD kinase
poly(P)/ATPdependent NAD kinase
polyP/ATP-dependent NAD kinase
polyphosphate/ATP-NAD kinase
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Ppnk
sll1415
Yef1p
YfjB
YjbN
NAD kinase
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NAD kinase
Corynebacterium glutamicum subsp. lactofermentum JHI3-156
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NADK
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poly(P)/ATPdependent NAD kinase
Corynebacterium glutamicum subsp. lactofermentum JHI3-156
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Ppnk
Corynebacterium glutamicum subsp. lactofermentum JHI3-156
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + NAD+ = ADP + NADP+
isoenzyme 1: ping-pong mechanism. Isoenzyme 2: sequential mechanism
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ATP + NAD+ = ADP + NADP+
AMP portion of ATP uses the same binding site as the nicotinamide ribose portion of NAD/NADP, proposal for phosphate transfer mechanism
ATP + NAD+ = ADP + NADP+
NAD+-binding mode and intersubunit contact
ATP + NAD+ = ADP + NADP+
isoenzyme 1: ping-pong mechanism. Isoenzyme 2: sequential mechanism
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ATP + NAD+ = ADP + NADP+
NAD+-binding mode and intersubunit contact
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ATP + NAD+ = ADP + NADP+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
ATP:NAD+ 2'-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY
9032-66-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
hexametaphosphate + NAD+
NADP+ + ?
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47% of the activity with ATP
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?
tetrapolyphosphate + NAD+
tripolyphosphate + NADP+
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84% activity compared to ATP
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?
ATP + NAD+
ADP + NADP+
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the Ca2+-calmodulin-dependent NAD+ kinase isoforms, amongst which is the isoform bound to mitochondrial membranes play an important role at the end of sensu stricto germination and during the following growth of Avena sativa
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?
ATP + NAD+
ADP + NADP+
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the 410000 Da isoenzyme could be a housekeeping enzyme, the 63000 Da isoenzyme could be mainly involved in the adaption and response of Avena sativa to environmental signals or stress through changes of redox potential and/or calcium signalling pathways
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?
ATP + NAD+
ADP + NADP+
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key enzyme for NADP+ metabolism and quinolinic acid metabolism
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?
ATP + NAD+
ADP + NADP+
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ATP is the preferred phosphoryl donor and NAD+ is the preferred acceptor
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?
ATP + NAD+
ADP + NADP+
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the catalytic efficiency with ATP as phosphate donor for phosphorylation of NAD is higher than with polyphosphate. The enzyme prefers ATP over ADP and polyphosphate(20)
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?
ATP + NAD+
ADP + NADP+
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the catalytic efficiency with ATP as phosphate donor for phosphorylation of NAD is higher than with polyphosphate. The enzyme prefers ATP over ADP and polyphosphate(20)
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?
ATP + NAD+
ADP + NADP+
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ATP is the preferred phosphoryl donor and NAD+ is the preferred acceptor
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?
ATP + NAD+
ADP + NADP+
Corynebacterium glutamicum subsp. lactofermentum
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ATP is the preferred phosphoryl donor and NAD+ is the preferred acceptor
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?
ATP + NAD+
ADP + NADP+
Corynebacterium glutamicum subsp. lactofermentum JHI3-156
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ATP is the preferred phosphoryl donor and NAD+ is the preferred acceptor
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?
ATP + NAD+
ADP + NADP+
50% activity compared to NADH
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?
ATP + NAD+
ADP + NADP+
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isoenzyme 1: most effective phosphate donor. Isoenzyme 2: 35% of the activity with GTP
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?
ATP + NAD+
ADP + NADP+
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treatment with AlCl3 of cell grown heterotrophically grown in darkness at pH 3.5 in the presence of lactate as sole carbon source, slows down the culture growth and suppresses the peak of NAD+ kinase activity, which characterizes the beginning of the exponential phase of growth of the control cultures, possible explanations
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?
ATP + NAD+
ADP + NADP+
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treatment with AlCl3 of cell grown heterotrophically grown in darkness at pH 3.5 in the presence of lactate as sole carbon source, slows down the culture growth and suppresses the peak of NAD+ kinase activity, which characterizes the beginning of the exponential phase of growth of the control cultures, possible explanations
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?
ATP + NAD+
ADP + NADP+
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isoenzyme 1: most effective phosphate donor. Isoenzyme 2: 35% of the activity with GTP
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?
ATP + NAD+
ADP + NADP+
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preferentially accepts NAD+ as substrate. At 100 micromol, NAD+ is 10fold faster phosphorylated than NADH
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?
ATP + NAD+
ADP + NADP+
NAD+ kinase is the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+
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?
ATP + NAD+
ADP + NADP+
the enzyme is required for the de novo synthesis of NADP+ from NAD+
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?
ATP + NAD+
ADP + NADP+
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Asp-45 is a key residue for the catalytic activity of NADK1
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?
ATP + NAD+
ADP + NADP+
the enzyme regulates the intracellular balance of NAD(H) and NADP(H)
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?
ATP + NAD+
ADP + NADP+
the enzyme regulates the intracellular balance of NAD(H) and NADP(H)
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?
ATP + NAD+
ADP + NADP+
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the membranal Ca2+-calmodulin-dependent enzyme might be important for early growth metabolism. Except for drought-stressed Phaseolus vulgaris at the stage of radicle protrusion in which NAD+ kinase activities are not perturbed, in both Phaseolus vulgaris and Phaseolus acutifolius NAD+ kinase activities temporarily decrease in response to drought stress, these being restored after subsequent rehydration
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?
ATP + NAD+
ADP + NADP+
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the membranal Ca2+-calmodulin-dependent enzyme might be important for early growth metabolism. Except for drought-stressed Phaseolus vulgaris at the stage of radicle protrusion in which NAD+ kinase activities are not perturbed, in both Phaseolus vulgaris and Phaseolus acutifolius NAD+ kinase activities temporarily decrease in response to drought stress, these being restored after subsequent rehydration
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?
ATP + NAD+
ADP + NADP+
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NAD kinase is responsible for the light-induced conversion of NAD to NADP in the chloroplast
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?
ATP + NAD+
ADP + NADP+
Utr1 is responsible for essentially all of the NAD/NADH kinase activity resident in the cytoplasm
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?
ATP + NAD+
ADP + NADP+
Yef1 contributes very slightly to total NAD and NADH kinase activities in vivo
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?
ATP + NAD+
ADP + NADP+
specific activity is 43fold higher than with NADH and ATP
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?
ATP + NAD+
ADP + NADP+
specific activity is about 3fold higher than with NADH
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?
ATP + NAD+
ADP + NADP+
the enzyme exhibits very high affinity for NAD+ compared to adenosine triphosphate
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?
ATP + NAD+
ADP + NADP+
the enzyme exhibits very high affinity for NAD+ compared to adenosine triphosphate
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?
ATP + NADH
ADP + NADPH
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conversion is slow at a NADH concentration of 5 mM. At lower concentrations (50-150 micromol) and particularly when NAD+ is concomitantly present as substrate, NADH becomes farmore efficiently phosphorylated
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?