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Literature summary for 3.4.17.10 extracted from
- Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in beta-cells (2005), Endocrinology, 146, 1808-1817.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | metabolic analysis of female and male heterozygous and homozygeous enzyme-deficient mutant mice, CPEfat/fat, in comparison to the wild-type mice, the mutant mice show reduced pro-islet amyloid polypeptide processing activity and reduced levels of PC2-chaperone protein 7B2 and prohormone invertase PC2, but not PC1/3, in beta cells, overview | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-islet amyloid polypeptide + H2O | Mus musculus | processing in pancreatic beta-cells | islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
female and male mice | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially by isolation of beta-islet cells | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Mus musculus | - |
| pancreatic beta cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
metabolic parameters of wild-type, heterozygous and homozygeous enzyme-deficient mutant mice, overview | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-islet amyloid polypeptide + H2O | processing | Mus musculus | islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide | - |
? | |
| pro-islet amyloid polypeptide + H2O | processing in pancreatic beta-cells | Mus musculus | islet amyloid polypeptide + pro-islet amyloid polypeptide propeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPE | - |
Mus musculus |
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Release 2023.1 (January 2023)
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