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Literature summary for 2.7.1.23 extracted from

  • Gray, J.P.; Alavian, K.N.; Jonas, E.A.; Heart, E.A.
    NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic beta-cells (2012), Am. J. Physiol. Endocrinol. Metab., 303, E191-E199.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.23

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus F7EXV6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 832/13 cell
-
 Rattus norvegicus
-
pancreatic beta cell
-
 Mus musculus
-
pancreatic beta cell
-
 Rattus norvegicus
-
pancreatic islet
-
 Mus musculus
-
pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NAD+
-
 Mus musculus ADP + NADP+
-
 ?
ATP + NAD+
-
 Rattus norvegicus ADP + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
ATP: NAD(H) 2'-phosphotransferase
-
 Mus musculus
ATP: NAD(H) 2'-phosphotransferase
-
 Rattus norvegicus
NAD kinase
-
 Mus musculus
NAD kinase
-
 Rattus norvegicus
NADK
-
 Mus musculus
NADK
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme regulates the size of the NADPH pool and insulin secretion in pancreatic beta-cells. Enzyme overexpression also protects beta-cells against oxidative damage by the redox cycling agent menadione and reverses menadione-mediated inhibition of glucose-stimulated insulin secretion Mus musculus
physiological function the enzyme regulates the size of the NADPH pool and insulin secretion in pancreatic beta-cells. Enzyme overexpression also protects beta-cells against oxidative damage by the redox cycling agent menadione and reverses menadione-mediated inhibition of glucose-stimulated insulin secretion Rattus norvegicus