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3-hydroxy-3-methylglutaryl coenzyme A reductase kinase
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3-hydroxy-3-methylglutaryl-CoA reductase kinase
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5'-AMP-activated protein kinase
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5'-AMP-activated protein kinase catalytic subunit alpha-1
5-AMP-activated protein kinase
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adenosine 5'-monophosphate-activated protein kinase
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adenosine 5-monophosphate-activated protein kinase
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adenosine monophosphate-activated protein kinase
adenosine monophosphateactivated protein kinase
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AMP-activated protein kinase
AMP-activated protein kinase alpha
AMP-activated protein kinase alpha1
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AMP-activated protein kinase alpha2 subunit
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AMPK alpha2
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catalytic subunit
AMPKalpha1beta1gamma1
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isoform
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase
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EC 2.7.1.109
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formerly
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hydroxymethylglutaryl coenzyme A reductase kinase
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hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating)
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SNF1-interacting protein 1
SNF1-interacting protein 2
SNF1-interacting protein 3
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase
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additional information
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AMPK is a member of the serine/threonin protein kinases, as well as of a metabolite-sensing kinase family
5'-AMP-activated protein kinase catalytic subunit alpha-1

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5'-AMP-activated protein kinase catalytic subunit alpha-1
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5'-AMP-activated protein kinase catalytic subunit alpha-1
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adenosine monophosphate-activated protein kinase

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adenosine monophosphate-activated protein kinase
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AMP-activated protein kinase

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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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662296, 665496, 690657, 690725, 691704, 692001, 692091, 692365, 693032, 693151, 693205, 693207, 694825, 701571, 701572, 701573, 702079, 703102, 703277, 703348, 703612, 704431, 704459, 704545, 705267, 705694, 705799, 705939, 706364, 706902, 761093
AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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665636, 687732, 690346, 691621, 692170, 692365, 692814, 693047, 694183, 701571, 701572, 701573, 701620, 702079, 702510, 703241, 703277, 703348, 703386, 703612, 703617, 703618, 704122, 704431, 704433, 704450, 705267, 705939, 706085, 760259, 760351
AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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663952, 665636, 684366, 690726, 691132, 691165, 691556, 691704, 692000, 692195, 692277, 692365, 692682, 693207, 693356, 701571, 701572, 701573, 703277, 703348, 703381, 704433, 704688, 704936, 705267, 705884, 705939, 761360, 761734, 762101
AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase
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AMP-activated protein kinase alpha

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AMP-activated protein kinase alpha
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AMPK

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AMPK
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662296, 665496, 690657, 690725, 691704, 692001, 692091, 692267, 692365, 692554, 693032, 693205, 693207, 693328, 694825, 701571, 701572, 701573, 702079, 703102, 703277, 703348, 703612, 704431, 704459, 704545, 705267, 705694, 705799, 705939, 706364, 706902, 761093, 761640
AMPK
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665636, 687732, 690346, 691621, 692170, 692365, 692814, 693047, 694183, 701571, 701572, 701573, 701620, 702079, 702510, 703241, 703277, 703348, 703386, 703612, 703617, 703618, 704122, 704431, 704433, 704450, 705267, 705939, 706085, 760351
AMPK
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663952, 663969, 665636, 684366, 690726, 691132, 691165, 691556, 691704, 692000, 692195, 692267, 692277, 692365, 692682, 693207, 693356, 701571, 701572, 701573, 703277, 703348, 703381, 704433, 704688, 704936, 705267, 705884, 705939, 761360, 761734, 762101
AMPKalpha

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AMPKalpha1

subunit
AMPKalpha2

subunit
Snf1

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Snf1
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homolog to mammalian AMPK
Snf1
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homologue of mammalian AMPK catalytic alpha subunit
Snf1
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yeast homolog of mammalian AMPK
Snf1
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homologue of mammalian AMPK catalytic alpha subunit
Snf1 kinase

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Snf1 kinase
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i.e. sucrose non-fermenting 1 kinase
SNF1-interacting protein 1

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SNF1-interacting protein 1
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SNF1-interacting protein 2

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SNF1-interacting protein 2
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SNF1-interacting protein 3

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SNF1-interacting protein 3
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SNF4

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homologue of mammalian AMPK catalytic gamma1 subunit
SNF4
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homologue of mammalian AMPK catalytic gamma1 subunit
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AMP + H2O
IMP + NH3
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ir
ATP + 3-hydroxy-3-methyl-glutaryl-CoA reductase
ADP + [3-hydroxy-3-methyl-glutaryl-CoA reductase]phosphate
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?
ATP + 3-mercaptopyruvate sulfurtransferase
ADP + phosphorylated 3-mercaptopyruvate sulfurtransferase
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?
ATP + acetyl-CoA carboxylase
ADP + phosphorylated acetyl-CoA carboxylase
ATP + acetyl-CoA carboxylase
ADP + [acetyl-CoA carboxylase] phosphate
ATP + acetyl-CoA carboxylase
ADP + [acetyl-CoA carboxylase]phosphate
ATP + acetyl-CoA carboxylase 1
ADP + phosphorylated acetyl-CoA carboxylase 1
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?
ATP + actin
ADP + [actin]phosphate
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?
ATP + acylamino-acid-releasing enzyme
ADP + phosphorylated acylamino-acid-releasing enzyme
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?
ATP + adenylate kinase isoenzyme 1
ADP + phosphorylated adenylate kinase isoenzyme 1
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?
ATP + adipose hormone-sensitive lipase
ADP + adipose hormone-sensitive lipase phosphate
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?
ATP + adipose hormone-sensitive lipase
ADP + [adipose hormone-sensitive lipase] phosphate
ATP + ATF1
ADP + phospho-ATF1
ATP + ATF2
ADP + phospho-ATF2
ATP + ATPase
ADP + [ATPase]phosphate
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?
ATP + band 3 anion transport protein
ADP + phosphorylated band 3 anion transport protein
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?
ATP + beta actin
ADP + phosphorylated beta actin
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?
ATP + beta-synuclein
ADP + [beta-synuclein]phosphate
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?
ATP + biotin-GGHMRSAMSGLHLVKRR-NH2
ADP + phosphorylated biotin-GGHMRSAMpSGLHLVKRR-NH2
ATP + bis(5'-nucleosyl)-tetraphosphatase
ADP + [bis(5'-nucleosyl)-tetraphosphatase]phosphate
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?
ATP + bisphosphoglycerate mutase
ADP + phosphorylated bisphosphoglycerate mutase
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?
ATP + bovine serum albumin
ADP + [bovine serum albumin] phosphate
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fraction V
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?
ATP + carbonic anhydrase 1
ADP + phosphorylated carbonic anhydrase 1
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?
ATP + casein
ADP + casein phosphate
ATP + catalase
ADP + phosphorylated catalase
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?
ATP + citrate synthase
ADP + [citrate synthase]phosphate
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?
ATP + collapsing response mediator protein-2
ADP + [collapsing response mediator protein-2]phosphate
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?
ATP + CREB
ADP + phospho-CREB
ATP + CREB1
ADP + phospho-CREB1
ATP + CREBL2
ADP + phospho-CREBL2
ATP + CREM
ADP + phospho-CREM
ATP + Cy5-SAMS peptide
ADP + phosphorylated Cy5-SAMS peptide
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?
ATP + cytoplasmic malate dehydrogenase
ADP + phosphorylated cytoplasmic malate dehydrogenase
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?
ATP + dephospho-alpha,beta-tubulin
ADP + [alpha,beta-tubulin] phosphate
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relative kinase activity high MW-kinase 15%
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?
ATP + dephospho-beta-tubulin
ADP + [beta-tubulin]phosphate
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?
ATP + dihydropteridine reductase
ADP + phosphorylated dihydropteridine reductase
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?
ATP + dihydropyrimidinase-like 2
ADP + [dihydropyrimidinase-like 2]phosphate
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?
ATP + DNA damage-binding protein 1
ADP + phosphorylated DNA damage-binding protein 1
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?
ATP + dynein intermediate chain 2
ADP + [dynein intermediate chain 2]phosphate
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?
ATP + elongation factor Ts
ADP + [elongation factor Ts]phosphate
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?
ATP + elongation factor Tu
ADP + [elongation factor Tu]phosphate
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?
ATP + erythrocyte spectrin alpha chain
ADP + phosphorylated erythrocyte spectrin alpha chain
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?
ATP + erythrocyte spectrin beta chain
ADP + phosphorylated erythrocyte spectrin beta chain
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?
ATP + eukaryotic elongation factor 2 kinase
ADP + phosphorylated eukaryotic elongation factor 2 kinase
ATP + far upstream element binding protein 1
ADP + [far upstream element binding protein 1]phosphate
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?
ATP + fascin homologue 1
ADP + [fascin homologue 1]phosphate
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?
ATP + flavin reductase
ADP + phosphorylated flavin reductase
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?
ATP + glial fibrillary acidic protein
ADP + [glial fibrillary acidic protein]phosphate
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?
ATP + glutamate dehydrogenase 1
ADP + [glutamate dehydrogenase 1]phosphate
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?
ATP + glutamine synthetase
ADP + [glutamine synthetase]phosphate
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?
ATP + glutathione S-transferase omega-1
ADP + phosphorylated glutathione S-transferase omega-1
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?
ATP + glutathione synthetase
ADP + phosphorylated glutathione synthetase
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?
ATP + glyceraldehyde-3-phosphate dehydrogenase
ADP + [glyceraldehyde-3-phosphate dehydrogenase]phosphate
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?
ATP + glycerophosphate acyltransferase
ADP + [glycerophosphate acyltransferase]phosphate
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?
ATP + glycogen synthase
ADP + [glycogen synthase] phosphate
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relative kinase activity for low-MW kinase 7%, high MW-kinase 87%
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?
ATP + heat shock protein 8
ADP + [heat shock protein 8]phosphate
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?
ATP + heavy meromyosin
ADP + [heavy meromyosin] phosphate
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relative kinase activity for low-MW kinase 2%, high MW-kinase 100%
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?
ATP + heterogeneous nuclear ribonucleoproteins A2/B1
ADP + [heterogeneous nuclear ribonucleoproteins A2/B1]phosphate
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?
ATP + HGRSAMSGLHLVKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + histone 2A
?
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?
ATP + histone H1
ADP + phosphohistone H1
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?
ATP + histone H1 (IIIS)
ADP + [histone H1 (IIIS)] phosphate
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histones are better substrates for high-MW kinase than hydroxymethylglutaryl-CoA reductase, relative kinase activity for low-MW kinase 275%, high MW-kinase 103%
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?
ATP + histone H1B
ADP + phospho-histone H1B
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?
ATP + histone II-S
ADP + [histone II-S] phosphate
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relative kinase activity for low-MW kinase 38%, high MW-kinase 159%
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?
ATP + histone VIIIS
ADP + [histone VIIIS] phosphate
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relative kinase activity for low-MW kinase 65%, high MW-kinase 141%
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?
ATP + HMGSAMSGLHLVKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + HMHSAMSGLHLVKRR
?
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?
ATP + HMKSAMSGLHLVKRR
ADP + ?
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synthetic SAMS-containing peptide as substrate
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?
ATP + HMRSAGSGLHLVKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + HMRSAMSGLHGGKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + HMRSAMSGLHGVKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + HMRSAMSGLHLGKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + HMRSAMSGLHLVKRR
ADP + ?
ATP + HMRSAMTGLHGVKRR
?
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?
ATP + HMRSAMTGLHLVKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + HMRSAMYGLHLVKRR
ADP + ?
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SAMS-containing peptide as substrate
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?
ATP + hormone-sensitive lipase
ADP + phosphorylated hormone-sensitive lipase
ATP + JAK1
ADP + phosphorylated JAK1
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phosphorylation at Ser515 and Ser518
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?
ATP + MAP-2
ADP + MAP-2 phosphate
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relative kinase activity for low-MW kinase 14%, high MW-kinase 566%
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?
ATP + Mig1 protein
ADP + phosphorylated Mig1 protein
ATP + Mig2 protein
ADP + phosphorylated Mig2 protein
ATP + myelin basic protein
ADP + [myelin basic protein] phosphate
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moderate substrate for low-MW kinase, better than hydroxymethylglutaryl-CoA reductase for high-MW kinase, relative kinase activity for low-MW kinase 36%, high MW-kinase 238%
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?
ATP + myosin mixed light chains
ADP + [myosin mixed light chains] phosphate
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relative kinase activity for low-MW kinase 4%, high MW-kinase 27%
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?
ATP + neurofilament triplet L protein
ADP + [neurofilament triplet L protein]phosphate
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-
-
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?
ATP + Ngg1 interacting factor 3-like 1
ADP + [Ngg1 interacting factor 3-like 1]phosphate
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-
-
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?
ATP + NmrA-like family domain containing 1
ADP + [NmrA-like family domain containing 1]phosphate
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-
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?
ATP + nucleolin
ADP + [nucleolin]phosphate
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-
-
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?
ATP + p27
ADP + phospho-p27
ATP + p38
ADP + phospho-p38
ATP + p53
ADP + phospho-p53
ATP + peptide SAMS
ADP + phosphorylated peptide SAMS
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-
-
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?
ATP + peroxiredoxin-2
ADP + phosphorylated peroxiredoxin-2
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-
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?
ATP + peroxiredoxin-6
ADP + phosphorylated peroxiredoxin-6
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-
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?
ATP + PFK2
ADP + phospho-PFK2
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phosphorylation at Ser466 induced by UV radiation and H2O2 treatment
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?
ATP + phosphoglycerate kinase 1
ADP + phosphorylated phosphoglycerate kinase 1
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-
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?
ATP + phosphoribosylformylglycinamidine synthase
ADP + phosphorylated phosphoribosylformylglycinamidine synthase
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-
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?
ATP + phosphorylase B
ADP + [phosphorylase B] phosphate
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relative kinase activity high MW-kinase 12%
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-
?
ATP + phosvitin
ADP + phosvitin phosphate
ATP + PKZeta
?
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AMPK alpha phosphorylates PKZeta on residue Thr410 within the PKCzeta activation loop
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-
?
ATP + protamine
ADP + protamine phosphate
ATP + proteasome subunit alpha type-1
ADP + phosphorylated proteasome subunit alpha type-1
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-
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?
ATP + proteasome subunit alpha type-7
ADP + phosphorylated proteasome subunit alpha type-7
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-
-
?
ATP + protein GFAP
ADP + [protein GFAP]phosphate
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-
-
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?
ATP + protein kinase C and casein kinase substrate in neurons protein 1
ADP + [protein kinase C and casein kinase substrate in neurons protein 1]phosphate
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-
-
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?
ATP + protein NF-L
ADP + [protein NF-L]phosphate
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-
-
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?
ATP + purine nucleoside phosphorylase
ADP + phosphorylated purine nucleoside phosphorylase
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-
-
?
ATP + rabbit muscle glycogen synthase
ADP + [rabbit muscle glycogen synthase] phosphate
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rabbit muscle glycogen synthase
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-
?
ATP + recombinant human Kv1.5 channel
ADP + phosphorylated recombinant human Kv1.5 channel
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-
-
-
?
ATP + RNA-binding protein HUR
ADP + ?
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inhibits the protein by phosphorylation
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-
?
ATP + S-formylglutathione hydrolase
ADP + phosphorylated S-formylglutathione hydrolase
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-
-
?
ATP + selenium binding protein 1
ADP + phosphorylated selenium binding protein 1
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-
-
?
ATP + synapsin 1
ADP + [synapsin 1] phosphate
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as good substrate as hydroxymethylglutaryl-CoA reductase, relative kinase activity for low-MW kinase 151%, high MW-kinase 103%