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Information on EC 2.7.11.31 - [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

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IUBMB Comments
The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) . Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase . GTP can act instead of ATP
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The enzyme appears in viruses and cellular organisms
Synonyms
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase, 3-hydroxy-3-methylglutaryl-CoA reductase kinase, 5'-AMP-activated protein kinase, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5-AMP-activated protein kinase, AAK-2, adenosine 5'-monophosphate-activated protein kinase, adenosine 5-monophosphate-activated protein kinase, adenosine monophosphate-activated protein kinase, adenosine monophosphateactivated protein kinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
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