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IUBMB CommentsA pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
glutamic acid decarboxylase, gad65, gad67, glutamate decarboxylase, glutamic acid decarboxylase 65, glutamic acid decarboxylase 67, gad-65, gad-67, glutamate decarboxylase 67, l-glutamate decarboxylase,
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42 kDa biotin-coupled protein
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exhibits both glutamine synthetase activity and glutamate decarboxylase activity
65 kDa glutamic acid decarboxylase
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67 kDa glutamic acid decarboxylase
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Aspartate 1-decarboxylase
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Aspartic alpha-decarboxylase
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Cysteic acid decarboxylase
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Decarboxylase, glutamate
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gamma-Glutamate decarboxylase
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glutamate decarboxylase
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glutamate decarboxylase 1
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glutamate decarboxylase 65
glutamate decarboxylase 67
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glutamate decarboxylase A
glutamate decarboxylase B
Glutamic acid decarboxylase
glutamic acid decarboxylase 65
glutamic acid decarboxylase 67
glutamic acid decarboxylase-65
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glutamic acid decarboxylase-67
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glutamic acid decarboxylase67
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Glutamic decarboxylase
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L-Aspartate-alpha-decarboxylase
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L-glutamate 1-carboxylyase
L-Glutamate alpha-decarboxylase
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L-Glutamate decarboxylase
L-glutamate decarboxylase 65
L-glutamate decarboxylase 67
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L-Glutamic acid decarboxylase
L-Glutamic decarboxylase
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p42
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exhibits both glutamine synthetase activity and glutamate decarboxylase activity
additional information
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GAD belongs to a subset of pyridoxal 5'-phosphate-dependent enzymes classified as group 2
BmGAD
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BmGadB
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BMI_II334
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GAD
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GAD
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655357, 697040, 697049, 697426, 697579, 697617, 697841, 698395, 699151, 699668, 699674
GAD1
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GAD2
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GAD65
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GAD65
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65 kDa isoform of glutamic acid decarboxylase
GAD65
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65-kDa isoform of GAD
GAD65
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65-kilodalton isoform of glutamate decarboxylase
GAD67
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GAD67
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67 kDa form of the glutamic acid decarboxylase
GadA
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GadB
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GADB1
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gadlbhye1
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Glt decarboxylase
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glutamate decarboxylase 65
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glutamate decarboxylase 65
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glutamate decarboxylase 65
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glutamate decarboxylase A
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glutamate decarboxylase A
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glutamate decarboxylase B
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glutamate decarboxylase B
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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695971, 697040, 697049, 697426, 697564, 697572, 697617, 697841, 698395, 698535, 699668, 699674, 703503
Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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Glutamic acid decarboxylase
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glutamic acid decarboxylase 65
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glutamic acid decarboxylase 65
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isoform
glutamic acid decarboxylase 65
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glutamic acid decarboxylase 65
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65 kDa isoform of glutamic acid decarboxylase
glutamic acid decarboxylase 65
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glutamic acid decarboxylase 67
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glutamic acid decarboxylase 67
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glutamic acid decarboxylase 67
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glutamic acid decarboxylase 67
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glutamic acid decarboxylase 67
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glutamic acid decarboxylase 67
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67 kDa form of the glutamic acid decarboxylase
hGAD65
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L-glutamate 1-carboxylyase
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L-glutamate 1-carboxylyase
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L-glutamate 1-carboxylyase
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L-glutamate 1-carboxylyase
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L-Glutamate decarboxylase
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L-Glutamate decarboxylase
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L-glutamate decarboxylase 65
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L-glutamate decarboxylase 65
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L-glutamate decarboxylase 65
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L-Glutamic acid decarboxylase
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L-Glutamic acid decarboxylase
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L-Glutamic acid decarboxylase
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L-Glutamic acid decarboxylase
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L-Glutamic acid decarboxylase
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LbGAD
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LbGadB
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MGAD
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MGAD
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membrane-associated form of L-glutamate decarboxylase
ScGAD
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L-glutamate = 4-aminobutanoate + CO2
L-glutamate = 4-aminobutanoate + CO2
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L-glutamate = 4-aminobutanoate + CO2
reaction proceeds via radical mechanism
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oxidative deamination
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decarboxylation
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-alpha-Methylglutamate
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L-alpha-methylglutamate + O2
laevulinic acid + NH3
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L-Cysteic acid
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L-Cysteine sulfinic acid
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L-Glu
4-Aminobutanoate + CO2
L-glutamate
4-aminobutanoate + CO2
additional information
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L-Asp
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3-5% of the activity with L-Glu
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L-Asp
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Phe or 6-azauracil decrease specificity for L-Glu and increase specificity to L-Asp
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L-Asp
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2% of the activity with L-Glu
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L-Cysteine sulfinic acid
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L-Cysteine sulfinic acid
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8% of the activity with L-Glu
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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rate-limiting enzyme involved in the synthesis of gamma-aminobutyric acid
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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6-azauracil or Phe decrease specificity for L-Glu and increased specificity to L-Asp
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
4-Aminobutanoate + CO2
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L-Glu
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isoenzyme GAD2 may play a unique role in nitrogen metabolism
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L-Glu
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the enzyme is under the control of the asexual developmental cycle
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L-Glu
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production of 4-aminobutanoate, which is the major inhibitory neurotransmitter in the mammalian brain
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L-glutamate
4-aminobutanoate + CO2
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L-glutamate
4-aminobutanoate + CO2
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L-glutamate
4-aminobutanoate + CO2
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L-glutamate
4-aminobutanoate + CO2
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L-glutamate
4-aminobutanoate + CO2
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L-glutamate
4-aminobutanoate + CO2
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L-glutamate
4-aminobutanoate + CO2
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4.1.1.15 glutamate decarboxylase
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