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Literature summary for 4.1.1.15 extracted from
- Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts (2008), Mol. Biol. Rep., 36, 1469-1474.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene GAD67, cloning of four GAD67 transcripts, GAD67-C1, -C2, -C3, and -C4, produced by alternative splicing and polyadenlyation and translating a GAD protein with truncated pyridoxal 5'-phosphate binding domain, which leads to a lack of glutamate decarboxylase activity, expression in HEK-293 cells | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | Rattus norvegicus | glutamate decarboxylase is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid, the most important inhibitory neurotransmitter in central nervous system | 4-aminobutanoate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| epididymis | initial segment | Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| ovary | - |
Rattus norvegicus | - |
| pancreas | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
| uterus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | - |
Rattus norvegicus | 4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | glutamate decarboxylase is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid, the most important inhibitory neurotransmitter in central nervous system | Rattus norvegicus | 4-aminobutanoate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAD | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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