Ligand 4-aminobutanoate

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Basic Ligand Information

Molecular Structure
Picture of 4-aminobutanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO2
4-aminobutanoate
BTCSSZJGUNDROE-UHFFFAOYSA-N
Synonyms:
4-amino-1-butanoic acid, 4-amino-n-butanoate, 4-aminobutanoic acid, 4-aminobutyrate, 4-aminobutyric acid, gamma-amino-n-butyrate, gamma-aminobutanoate, gamma-aminobutanoic acid, gamma-aminobutyrate, gamma-aminobutyric acid


Show all pahtways known for Show all BRENDA pathways known for 4-aminobutanoate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-(gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
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Substrate in Enzyme-catalyzed Reactions (41 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-aminobutyric acid + 2-oxoglutarate + O2 = D-2-hydroxy-4-aminobutyric acid + succinate + CO2
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4-aminobutyric acid + H2O + O2 = 4-oxobutanoate + NH3 + H2O2
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4-aminobutanoate + O2 + H2O = succinate semialdehyde + NH3 + H2O2
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Z-Gln-Gly + gamma-aminobutyric acid = ?
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4-aminobutanoate + pyruvate = 4-oxobutanoate + L-alanine
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4-aminobutyrate + vanillin = vanillylamine + 4-oxobutyrate
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4-aminobutanoate + 2-oxoglutarate = succinic semialdehyde + L-glutamate
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4-aminobutanoate + 2-oxoglutarate = 4-oxobutanoate + L-glutamate
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4-aminobutanoate + pyruvate = succinic semialdehyde + L-alanine
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gamma-amino-n-butyrate + 4,5-dioxopentanoate = 5-aminolevulinate + succinic semialdehyde
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4-aminobutyrate + 2-oxoglutarate = succinic semialdehyde + L-glutamate
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4-aminobutanoate + 2-oxoglutarate = 4-oxobutanoate + D-glutamate
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4-aminobutyrate + 2-oxoglutarate = L-glutamate + acetaldehyde + sulfite
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4-aminobutanoate + 2-oxoglutarate = ? + L-glutamate
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4-aminobutanoate = propylamine + CO2
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ATP + 4-aminobutanoate + tRNALys = AMP + 4-aminobutyryl-tRNALys + diphosphate
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ATP + 4-aminobutanoate + BtrI acyl-carrier protein = ADP + phosphate + 4-aminobutanoyl-S-[BtrI acyl-carrier protein]
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ATP + 4-aminobutyrate + CoA = ADP + phosphate + 4-aminobutyryl-CoA
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ATP + gamma-aminobutyrate + NH4+ = ADP + phosphate + ?
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ATP + gamma-glutamylcysteine + gamma-aminobutyrate = ADP + phosphate + gamma-glutamylcysteinyl-4-aminobutyrate
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Product in Enzyme-catalyzed Reactions (47 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH
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4-aminobutyraldehyde + NAD+ + H2O = 4-aminobutyrate + NADH
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4-aminobutyraldehyde + NAD+ = 4-aminobutanoate + NADH
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5'-phospho-pyridoxyl-4-aminobutyrate + H2O + O2 = pyridoxal 5'-phosphate + 4-aminobutyrate + H2O2
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4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2
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homocarnosine + H2O = 4-aminobutyric acid + L-His
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pantoyl-gamma-aminobutyrate + H2O = 4-aminobutyrate + D-pantoate
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4-aminobutyramide + H2O = 4-aminobutanoate + NH3
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4-aminobutanoyl-CoA + H2O = 4-aminobutanoate + coenzyme A
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4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate
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4-Guanidinobutyrate + H2O = 4-Aminobutyrate + urea
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4-Guanidinobutyrate + H2O = 4-Aminobutyrate + urea
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4-guanidinobutyrate + H2O = 4-aminobutanoate + urea
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4-aminobutyronitrile + H2O = 4-aminobutyric acid + NH3
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4-aminobutyronitrile + H2O = 4-aminobutyric acid + NH3
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L-glutamate = 4-aminobutyric acid + CO2
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Glu = 4-Aminobutanoate + CO2
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Activator in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight activation
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induction during growth with 4-aminobutyrate (GABA)
stimulation, 177% of non-stimulated activity
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5 mM, relative activity 106%
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activates
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hypothesis: stimulate Na+/K+ transport via specific receptor inputs
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Inhibitor in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition
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inhibitor/substrate ratio = 3, 8% inhibition
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GABA, regulates the activity of topo I in mouse cerebellum sections, slightly and transiently inhibits topo I activity
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1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 13%
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3D Structure of Enzyme-Ligand-Complex (PDB) (37 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (34 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
878
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pH 9.8, 22°C

KM Value (68 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
6.66
-
pH 9.8, 22°C
0.51
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pH 8.8, 37°C, cosubstrate 2-oxoglutarate
8.3
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Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
440
-
-
44
-
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1.6
-
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0.00819
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pH and temperature not specified in the publication

References & Links

Links to other databases for 4-aminobutanoate

ChEBI
PubChem
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PubChem