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Literature summary for 4.1.1.15 extracted from
- Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-immunoreactive neuropil (2009), J. Affect. Disord., 113, 45-55.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | Homo sapiens | GAD is the key enzyme of GABA synthesis, alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders, overview. Increased relative density of GAD-immunoreactive neuropil, suggests the diathesis of GABAergic system specific for depressed suicidal patients | 4-aminobutanoate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes GAD65 and GAD67 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| entorhinal cortex | - |
Homo sapiens | - |
| hippocampus | - |
Homo sapiens | - |
| laterodorsal thalamic nucleus | - |
Homo sapiens | - |
| medial dorsal nucleus of thalamus | - |
Homo sapiens | - |
| additional information | quantitative immunohistochemic analysis GAD-immunoreactive neuropils of GAD65 and GAD67 isozymes in brains of depressed and healthy individuals, overview | Homo sapiens | - |
| prefrontal cortex | orbitofrontal, anterior cingulate, and dorsolateral | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | - |
Homo sapiens | 4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | GAD is the key enzyme of GABA synthesis, alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders, overview. Increased relative density of GAD-immunoreactive neuropil, suggests the diathesis of GABAergic system specific for depressed suicidal patients | Homo sapiens | 4-aminobutanoate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAD | - |
Homo sapiens |
| Glutamic acid decarboxylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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