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Literature summary for 4.1.1.15 extracted from

  • El Idrissi, A.; L'Amoreaux, W.J.
    Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: In vivo functional test for the activity of glutamic acid decarboxylase (2008), Neuroscience, 156, 693-699.
    View publication on PubMed
Search for more literature for 4.1.1.15

Activating Compound

Activating Compound Comment Organism Structure
additional information increased GAD expression in taurine-fed mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
isoniazide isoniazide-induced seizures are mediated primarily through competition with the cofactor pyridoxal 5'-phosphate resulting in the inhibition of GAD activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Mus musculus
-
 4-aminobutanoate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P48320 male FVB/NJ mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain cortex
-
 Mus musculus
-
brain stem
-
 Mus musculus
-
cerebellum
-
 Mus musculus
-
diencephalon
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Mus musculus 4-aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD
-
 Mus musculus
Glutamic acid decarboxylase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus