Literature summary for 4.1.1.15 extracted from

Luo, Y.; Lathia, J.; Mughal, M.; Mattson, M.P.
SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons (2008), J. Biol. Chem., 283, 24789-24800.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	stromal cell-derived factor alpha, SDF1alpha, rapidly induces the expression of the early growth response gene Egr1, a transcription factor involved in activity-dependent neuronal responses, in a concentration-dependent manner, which increases the expression of GAD67 at both the mRNA and protein levels, and increases the amount and neurite localization of gamma-aminobutyric acid, GABA, in neurons already expressing GABA. SDF1alpha-induced Egr1/GAD67 expression is mediated by the G protein-coupled CXCR4 receptor and activation of the ERK pathway, overview	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
GAD65 and GAD67 expression analysis in embryo and adult hippocampi	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a C-terminal 44-kDa truncated GAD, i.e. GAD44. GAD25 corresponds to the putative regulatory domain of the full-length protein, GAD44 contains the cofactor-binding site and enzymatic activity for synthesis of gamma-butyric acid	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-glutamate	Rattus norvegicus	-	4-aminobutanoate + CO2	-	?
additional information	Rattus norvegicus	SDF1alpha/CXCR4/G protein/ERK signaling induces the expression of the GAD67 system via Egr1 activation, a mechanism that may promote the maturation of GABAergic neurons during development	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isozymes GAD67 and GAD65, encoded by different genes	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	fetal brain: GAD67, adult brain: GAD67 and GAD65	Rattus norvegicus	-
embryo	glutamic acid decarboxylase in E18 embryonic hippocampal neurons	Rattus norvegicus	-
hippocampus	glutamic acid decarboxylase in E18 embryonic hippocampal neurons	Rattus norvegicus	-
neuron	glutamic acid decarboxylase in E18 embryonic hippocampal neurons	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamate	-	Rattus norvegicus	4-aminobutanoate + CO2	-	?
additional information	SDF1alpha/CXCR4/G protein/ERK signaling induces the expression of the GAD67 system via Egr1 activation, a mechanism that may promote the maturation of GABAergic neurons during development	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
GAD65	-	Rattus norvegicus
GAD67	-	Rattus norvegicus
Glutamic acid decarboxylase	-	Rattus norvegicus

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Release 2023.1 (January 2023)