Application | Comment | Organism |
---|---|---|
diagnostics | glutamic acid decarboxylase (GAD) is a rate-limiting enzyme for GABA synthesis and used as a reliable marker for inhibitory interneurons. There are differences in the distribution of inhibitory neurons according to the layer in the hippocampus. GAD67 immunoreactive neurons in the dog CA1 region are markedly decreased in the strata pyramidale and radiatum in aged dogs | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | Canis lupus familiaris | - |
4-aminobutanoate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | determination of GABAergic neurons in the hippocampal CA1 region at various ages of dogs using glutamic acid decarboxylase 67 (GAD67), which is a rate-limiting enzyme for GABA synthesis, and extent of alterations in number and function of inhibitory GABAergic interneurons in the hippocampus as a function of age, overview. GAD67 immunoreactive neurons in 1-year-old dogs are mainly detected in the stratum oriens. In the 6-year-old group, GAD67 immunoreactive neurons are evenly distributed in the CA1 region, and numbers of the neurons are highest among all experimental groups. Thereafter, GAD67 immunoreactive neurons are significantly decreased region with age: GAD67 immunoreactive neurons are scarcely found in the CA1 region in 10-year-old dogs. GAD67 immunoreactive neurons in the dog CA1 region are markedly decreased in the strata pyramidale and radiatum in aged dogs, overview | Canis lupus familiaris | - |
neuron | in the hippocampal CA1 region | Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | - |
Canis lupus familiaris | 4-aminobutanoate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAD67 | - |
Canis lupus familiaris |
glutamic acid decarboxylase 67 | - |
Canis lupus familiaris |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Canis lupus familiaris |
General Information | Comment | Organism |
---|---|---|
physiological function | glutamic acid decarboxylase 67 (GAD67), which is a rate-limiting enzyme for GABA synthesis, GAD67 is responsible for maintaining GABA baseline levels for both neurotransmitter and metabolite. Determination of GABAergic neurons in the hippocampal CA1 region at various ages of dogs using GAD67, and extent of alterations in number and function of inhibitory GABAergic interneurons in the hippocampus as a function of age, overview. The reduction of GAD67 immunoreactive neurons in the hippocampal CA1 region may be closely related to highly susceptibility to memory loss in old aged dogs | Canis lupus familiaris |