Literature summary for 4.1.1.15 extracted from

Kubo, K.; Nishikawa, K.; Hardy-Yamada, M.; Ishizeki, J.; Yanagawa, Y.; Saito, S.
Altered responses to propofol, but not ketamine, in mice deficient in the 65-kilodalton isoform of glutamate decarboxylase (2009), J. Pharmacol. Exp. Ther., 329, 592-599.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-glutamate	Mus musculus	-	4-aminobutanoate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamate	-	Mus musculus	4-aminobutanoate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
GAD65	65-kilodalton isoform of glutamate decarboxylase	Mus musculus

General Information

General Information	Comment	Organism
malfunction	GAD65 knockout mice show a diminished response to propofol, but not ketamine, indicating that GAD65-mediated 4-aminobutanoate synthesis plays an important role in hypnotic and immobilizing actions of propofol	Mus musculus

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Release 2023.1 (January 2023)