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Information on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)

for references in articles please use BRENDA:EC1.1.1.39

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IUBMB Comments

There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This particular form is found only in the plant kingdom. Unlike EC 1.1.1.38, which catalyses a similar reaction, this enzyme can not bind oxaloacetate, and thus does not decarboxylate exogeneously-added oxaloacetate. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating); and EC 1.1.1.83, D-malate dehydrogenase (decarboxylating).

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes

Synonyms
mitochondrial malic enzyme, cytosolic malic enzyme, malate dehydrogenase (decarboxylating), nad-me1, nad-dependent malic enzyme, nad-me2, m-nad-me, nad-meh, nad-preferring me, nad-preferring malic enzyme, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-malate + NAD+ = pyruvate + CO2 + NADH + H+
show the reaction diagram