Reference on EC 7.6.2.2 - ABC-type xenobiotic transporter and Organism(s) Homo sapiens and UniProt Accession Q5T3U5
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sharom, F.J.; Liu, R.; Romsicki, Y.; Lu, P.
Insight into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies
Biochim. Biophys. Acta
1461
327-345
1999
Homo sapiens, Mus musculus, Rattus norvegicus
Van Veen, H.W.; Konings, W.N.
The ABC family of multidrug transporters in microorganisms
Biochim. Biophys. Acta
1365
31-36
1998
Bacillus subtilis, Saccharomyces cerevisiae, Caenorhabditis elegans, Candida albicans, Cricetulus griseus, Escherichia coli, Entamoeba histolytica, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Levilactobacillus brevis, Lactococcus lactis, Leishmania donovani, Leishmania tarentolae, Staphylococcus aureus, Mycoplasma genitalium, Plasmodium falciparum
Cole, S.P.C.; Deeley, R.G.
Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
Bioessays
20
931-940
1998
Homo sapiens, Mus musculus
Frijters, C.M.G.; Ottenhoff, R.; van Wijland, M.J.A.; van Nieuwkerk, C.; Groen, A.K.; Oude Elferink, R.P.J.
Influence of bile salts on hepatic mdr2 P-glycoprotein expression
Adv. Enzyme Regul.
36
351-363
1996
Homo sapiens, Mus musculus
Keppler, D.; Knig, J.; Buchler, M.
The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes
Adv. Enzyme Regul.
37
321-333
1997
Homo sapiens, Rattus norvegicus
Bellamy, W.T.
P-glycoproteins and multidrug resistance
Annu. Rev. Pharmacol. Toxicol.
36
161-183
1996
Cricetinae, Homo sapiens, Mus musculus
Loe, D.W.; Deeley, R.G.; Cole, S.P.C.
Characterization of vincristine transport by the Mr 190000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione
Cancer Res.
58
5130-5136
1998
Homo sapiens
Zeng, H.; Liu, G.; Rea, P.A.; Kruh, G.D.
Transport of amphipathic anions by human multidrug resistance protein 3
Cancer Res.
60
4779-4784
2000
Homo sapiens
Fernandez-Moreno, M.A.; Carbo, L.; Cuesta, T.; Vallin, C.; Malpartida, F.
A silent ABC transporter isolated from Streptomyces rochei F20 induces multidrug resistance
J. Bacteriol.
180
4017-4023
1998
Homo sapiens, Streptomyces rochei, Streptomyces rochei F20
Wijnholds, J.; Mol, C.A.A.M.; van Deemter, L.; de Haas, M.; Scheffer, G.L.; Baas, F.; Beijnen, J.H.; Scheper, R.J.; Hatse, S.; de Clercq, E.; Balzarini, J.; Borst, P.
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
Proc. Natl. Acad. Sci. USA
97
7476-7481
2000
Homo sapiens
Mao, Q.; Deeley, R.G.; Vole, S.P.C.
Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles
J. Biol. Chem.
275
34166-34172
2000
Homo sapiens
Hipfner, D.R.; Mao, Q.; Qi, W.; Leslie, E.M.; Gao, M.; Deeley, R.G.; Cole, S.P.C.
Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP
J. Biol. Chem.
274
15420-15426
1999
Homo sapiens
Loe, D.W.; Stewart, R.K.; Massey, T.E.; Deeley, R.G.; Cole, S.P.C.
ATP-dependent transport of aflatoxin B1 and its glutathione conjugate by the product of the multidrug resistance protein (MRP) gene
Mol. Pharmacol.
51
1034-1041
1997
Homo sapiens
Paul, S.; Breuninger, L.M.; Kruh, G.D.
ATP-dependent transport of lipophilic cytotoxic drugs by membrane vesicles prepared from MRP-overexpressing HL60/ADR cells
Biochemistry
35
14003-14011
1996
Homo sapiens
Szentpetery, Z.; Sarkadi, B.; Bakos, E.; Varadi, A.
Functional studies on the MRP1 multidrug transporter: characterization of ABC-signature mutant variants
Anticancer Res.
24
449-456
2004
Homo sapiens
Kern, A.; Szentpetery, Z.; Liliom, K.; Bakos, E.; Sarkadi, B.; Varadi, A.
Nucleotides and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1 multidrug transporter
Biochem. J.
380
549-560
2004
Homo sapiens
Wang, E.J.; Casciano, C.N.; Clement, R.P.; Johnson, W.W.
Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein
Drug Metab. Dispos.
29
1080-1083
2001
Homo sapiens
Omote, H.; Al-Shawi, M.K.
A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein
J. Biol. Chem.
277
45688-45694
2002
Homo sapiens
Al-Shawi, M.K.; Polar, M.K.; Omote, H.; Figler, R.A.
Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein
J. Biol. Chem.
278
52629-52640
2003
Cricetulus griseus, Homo sapiens
Garrigues, A.; Escargueil, A.E.; Orlowski, S.
The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane
Proc. Natl. Acad. Sci. USA
99
10347-10352
2002
Homo sapiens
Bodo, A.; Bakos, E.; Szeri, F.; Varadi, A.; Sarkadi, B.
The role of multidrug transporters in drug availability, metabolism and toxicity
Toxicol. Lett.
140-141
133-143
2003
Homo sapiens
Gatlik-Landwojtowicz, E.; Aaenismaa, P.; Seelig, A.
Quantification and characterization of P-glycoprotein-substrate interactions
Biochemistry
45
3020-3032
2006
Homo sapiens
Wang, Y.; Hao, D.; Stein, W.D.; Yang, L.
A kinetic study of rhodamine123 pumping by P-glycoprotein
Biochim. Biophys. Acta
1758
1671-1676
2006
Homo sapiens
Bachmakov, I.; Werner, U.; Endress, B.; Auge, D.; Fromm, M.F.
Characterization of beta-adrenoceptor antagonists as substrates and inhibitors of the drug transporter P-glycoprotein
Fundam. Clin. Pharmacol.
20
273-282
2006
Homo sapiens
Katoh, M.; Suzuyama, N.; Takeuchi, T.; Yoshitomi, S.; Asahi, S.; Yokoi, T.
Kinetic analyses for species differences in P-glycoprotein-mediated drug transport
J. Pharm. Sci.
95
2673-2683
2006
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Lee, Y.M.; Cui, Y.; Koenig, J.; Risch, A.; Jaeger, B.; Drings, P.; Bartsch, H.; Keppler, D.; Nies, A.T.
Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)
Pharmacogenetics
14
213-223
2004
Homo sapiens
Nabekura, T.; Yamaki, T.; Ueno, K.; Kitagawa, S.
Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1
Biochem. Biophys. Res. Commun.
369
363-368
2008
Homo sapiens
Kimura, Y.; Kioka, N.; Kato, H.; Matsuo, M.; Ueda, K.
Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol
Biochem. J.
401
597-605
2007
Homo sapiens
Wan, C.K.; Zhu, G.Y.; Shen, X.L.; Chattopadhyay, A.; Dey, S.; Fong, W.F.
Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells
Biochem. Pharmacol.
72
824-837
2006
Homo sapiens
Shirasaka, Y.; Onishi, Y.; Sakurai, A.; Nakagawa, H.; Ishikawa, T.; Yamashita, S.
Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs
Biol. Pharm. Bull.
29
2465-2471
2006
Homo sapiens
Chang, C.; Bahadduri, P.M.; Polli, J.E.; Swaan, P.W.; Ekins, S.
Rapid identification of P-glycoprotein substrates and inhibitors
Drug Metab. Dispos.
34
1976-1984
2006
Homo sapiens
Feng, B.; Mills, J.B.; Davidson, R.E.; Mireles, R.J.; Janiszewski, J.S.; Troutman, M.D.; de Morais, S.M.
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system
Drug Metab. Dispos.
36
268-275
2008
Homo sapiens, Mus musculus
Lima, S.A.; Tavares, J.; Gameiro, P.; de Castro, B.; Cordeiro-da-Silva, A.
Flurazepam inhibits the P-glycoprotein transport function: an insight to revert multidrug-resistance phenotype
Eur. J. Pharmacol.
581
30-36
2008
Homo sapiens
Mueller, M.; Klein, I.; Kopacsi, S.; Remaley, A.T.; Rajnavoelgyi, E.; Sarkadi, B.; Varadi, A.
Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstane stimulated membrane ATPase activity
FEBS Lett.
580
6139-6144
2006
Homo sapiens
Heikkinen, A.T.; Moenkkoenen, J.
Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics
Int. J. Pharm.
346
169-172
2008
Homo sapiens
Sauna, Z.E.; Nandigama, K.; Ambudkar, S.V.
Exploiting reaction intermediates of the ATPase reaction to elucidate the mechanism of transport by P-glycoprotein (ABCB1)
J. Biol. Chem.
281
26501-26511
2006
Homo sapiens
Zastre, J.; Jackson, J.K.; Wong, W.; Burt, H.M.
Methoxypolyethylene glycol-block-polycaprolactone diblock copolymers reduce P-glycoprotein efflux in the absence of a membrane fluidization effect while stimulating P-glycoprotein ATPase activity
J. Pharm. Sci.
96
864-875
2007
Homo sapiens
Limtrakul, P.; Chearwae, W.; Shukla, S.; Phisalphong, C.; Ambudkar, S.V.
Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
Mol. Cell. Biochem.
296
85-95
2007
Homo sapiens
Collnot, E.M.; Baldes, C.; Wempe, M.F.; Kappl, R.; Huettermann, J.; Hyatt, J.A.; Edgar, K.J.; Schaefer, U.F.; Lehr, C.M.
Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity
Mol. Pharmacol.
4(3)
465-474
2007
Homo sapiens
Fong, W.F.; Wan, C.K.; Zhu, G.Y.; Chattopadhyay, A.; Dey, S.; Zhao, Z.; Shen, X.L.
Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexes
Planta Med.
73
212-220
2007
Homo sapiens
Etheridge, A.S.; Black, S.R.; Patel, P.R.; So, J.; Mathews, J.M.
An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents
Planta Med.
73
731-741
2007
Homo sapiens
Molnar, J.; Kars, M.D.; Guenduez, U.; Engi, H.; Schumacher, U.; Van Damme, E.J.; Peumans, W.J.; Makovitzky, J.; Gyemant, N.; Molnar, P.
Interaction of tomato lectin with ABC transporter in cancer cells: Glycosylation confers functional conformation of P-gp
Acta Histochem.
111
329-333
2009
Homo sapiens
Letourneau, I.J.; Nakajima, A.; Deeley, R.G.; Cole, S.P.
Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter
Biochem. Pharmacol.
75
1659-1669
2008
Homo sapiens
Crowley, E.; OMara, M.L.; Reynolds, C.; Tieleman, D.P.; Storm, J.; Kerr, I.D.; Callaghan, R.
Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1
Biochemistry
48
6249-6254
2009
Homo sapiens
Fong, W.F.; Shen, X.L.; Globisch, C.; Wiese, M.; Chen, G.Y.; Zhu, G.Y.; Yu, Z.L.; Tse, A.K.; Hu, Y.J.
Methoxylation of 3,4-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells
Bioorg. Med. Chem.
16
3694-3703
2008
Homo sapiens
Becker, J.P.; Depret, G.; Van Bambeke, F.; Tulkens, P.M.; Prevost, M.
Molecular models of human P-glycoprotein in two different catalytic states
BMC Struct. Biol.
9
3
2009
Homo sapiens
Hopper-Borge, E.; Xu, X.; Shen, T.; Shi, Z.; Chen, Z.S.; Kruh, G.D.
Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B
Cancer Res.
69
178-184
2009
Homo sapiens
Dong, X.; Mattingly, C.A.; Tseng, M.T.; Cho, M.J.; Liu, Y.; Adams, V.R.; Mumper, R.J.
Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP
Cancer Res.
69
3918-3926
2009
Homo sapiens
Wesolowska, O.; Hendrich, A.B.; Laniapietrzak, B.; Wisniewski, J.; Molnar, J.; Ocsovszki, I.; Michalak, K.
Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids
Cell. Mol. Biol. Lett.
14
199-221
2009
Homo sapiens
Grant, C.E.; Gao, M.; DeGorter, M.K.; Cole, S.P.; Deeley, R.G.
Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
Drug Metab. Dispos.
36
2571-2581
2008
Homo sapiens
Lagas, J.S.; van der Kruijssen, C.M.; van de Wetering, K.; Beijnen, J.H.; Schinkel, A.H.
Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone
Drug Metab. Dispos.
37
129-136
2009
Canis lupus familiaris, Homo sapiens
Rau, S.; Autschbach, F.; Riedel, H.D.; Konig, J.; Kulaksiz, H.; Stiehl, A.; Riemann, J.F.; Rost, D.
Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas
Eur. J. Clin. Invest.
38
134-142
2008
Homo sapiens
Yasunaga, M.; Takemura, M.; Fujita, K.; Yabuuchi, H.; Wada, M.
Molecular cloning and functional characterization of cynomolgus monkey multidrug resistance-associated protein 2 (MRP2)
Eur. J. Pharm. Sci.
35
326-334
2008
Macaca fascicularis, Homo sapiens
Nabekura, T.; Yamaki, T.; Kitagawa, S.
Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
Eur. J. Pharmacol.
600
45-49
2008
Homo sapiens
Koehn, J.; Fountoulakis, M.; Krapfenbauer, K.
Multiple drug resistance associated with function of ABC-transporters in diabetes mellitus: molecular mechanism and clinical relevance
Infect. Disord. Drug Targets
8
109-118
2008
Homo sapiens
Jimenez-Alonso, S.; Perez-Lomas, A.L.; Estevez-Braun, A.; Munoz Martinez, F.; Chavez Orellana, H.; Ravelo, A.G.; Gamarro, F.; Castanys, S.; Lopez, M.
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania
J. Med. Chem.
51
7132-7143
2008
Homo sapiens
Gannon, M.K.; Holt, J.J.; Bennett, S.M.; Wetzel, B.R.; Loo, T.W.; Bartlett, M.C.; Clarke, D.M.; Sawada, G.A.; Higgins, J.W.; Tombline, G.; Raub, T.J.; Detty, M.R.
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide switch for ATPase activity
J. Med. Chem.
52
3328-3341
2009
Homo sapiens
Karla, P.K.; Quinn, T.L.; Herndon, B.L.; Thomas, P.; Pal, D.; Mitra, A.
Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux
J. Ocul. Pharmacol. Ther.
25
121-132
2009
Oryctolagus cuniculus, Homo sapiens
Yang, Z.; Wu, D.; Bui, T.; Ho, R.J.
A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport
J. Pharmacol. Exp. Ther.
327
474-481
2008
Homo sapiens (P08183), Homo sapiens
Conseil, G.; Rothnie, A.J.; Deeley, R.G.; Cole, S.P.
Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1)
Mol. Pharmacol.
75
397-406
2009
Homo sapiens
Kodan, A.; Shibata, H.; Matsumoto, T.; Terakado, K.; Sakiyama, K.; Matsuo, M.; Ueda, K.; Kato, H.
Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells
Protein Expr. Purif.
66
7-14
2009
Homo sapiens
Russel, F.G.; Koenderink, J.B.; Masereeuw, R.
Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
Trends Pharmacol. Sci.
29
200-207
2008
Homo sapiens, Mus musculus
Ali, M.M.; Agha, F.G.; El-Sammad, N.M.; Hassan, S.K.
Modulation of anticancer drug-induced P-glycoprotein expression by naringin
Z. Naturforsch. C
64
109-116
2009
Homo sapiens
Lee, E.; Enomoto, R.; Koshiba, C.; Hirano, H.
Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells
Ann. N. Y. Acad. Sci.
1171
132-136
2009
Homo sapiens
Namanja, H.A.; Emmert, D.; Pires, M.M.; Hrycyna, C.A.; Chmielewski, J.
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer
Biochem. Biophys. Res. Commun.
388
672-676
2009
Homo sapiens
Hemauer, S.J.; Patrikeeva, S.L.; Nanovskaya, T.N.; Hankins, G.D.; Ahmed, M.S.
Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles
Biochem. Pharmacol.
78
1272-1278
2009
Homo sapiens
Zeinyeh, W.; Alameh, G.; Radix, S.; Grenot, C.; Dumontet, C.; Walchshofer, N.
Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux
Bioorg. Med. Chem. Lett.
20
3165-3168
2010
Homo sapiens
Riccioni, R.; Dupuis, M.L.; Bernabei, M.; Petrucci, E.; Pasquini, L.; Mariani, G.; Cianfriglia, M.; Testa, U.
The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor
Blood Cells Mol. Dis.
45
86-92
2010
Homo sapiens
Wei, N.; Sun, H.; Wang, F.; Liu, G.
H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein
Cancer Chemother. Pharmacol.
67
1017-1025
2011
Homo sapiens
Zhang, L.; Ma, S.
Efflux pump inhibitors: a strategy to combat P-glycoprotein and the NorA multidrug resistance pump
ChemMedChem
5
811-822
2010
Homo sapiens
Iwanaga, K.; Hayashi, M.; Hamahata, Y.; Miyazaki, M.; Shibano, M.; Taniguchi, M.; Baba, K.; Kakemi, M.
Furanocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein
Drug Metab. Dispos.
38
1286-1294
2010
Homo sapiens
Hulgan, T.; Donahue, J.P.; Smeaton, L.; Pu, M.; Wang, H.; Lederman, M.M.; Smith, K.; Valdez, H.; Pilcher, C.; Haas, D.W.; Haas, D.W.
Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors
Eur. J. Clin. Pharmacol.
65
1081-1088
2009
Homo sapiens
Choi, D.H.; Chung, J.H.; Choi, J.S.
Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin
Eur. J. Clin. Pharmacol.
66
285-290
2010
Homo sapiens
El-Readi, M.Z.; Hamdan, D.; Farrag, N.; El-Shazly, A.; Wink, M.
Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines
Eur. J. Pharmacol.
626
139-145
2010
Homo sapiens
Zrieki, A.; Farinotti, R.; Buyse, M.
Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo
Eur. J. Pharmacol.
636
189-197
2010
Homo sapiens
Wesolowska, O.; Wisniewski, J.; Sroda, K.; Krawczenko, A.; Bielawska-Pohl, A.; Paprocka, M.; Dus, D.; Michalak, K.
8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1
Eur. J. Pharmacol.
644
32-40
2010
Homo sapiens
Sato, T.; Kodan, A.; Kimura, Y.; Ueda, K.; Nakatsu, T.; Kato, H.
Functional role of the linker region in purified human P-glycoprotein
FEBS J.
276
3504-3516
2009
Homo sapiens
Martelli, C.; Coronnello, M.; Dei, S.; Manetti, D.; Orlandi, F.; Scapecchi, S.; Novella Romanelli, M.; Salerno, M.; Mini, E.; Teodori, E.
Structure-activity relationships studies in a series of N,N-bis(alkanol)amine aryl esters as P-glycoprotein (Pgp) dependent multidrug resistance (MDR) inhibitors
J. Med. Chem.
53
1755-1762
2010
Homo sapiens
Arnaud, O.; Koubeissi, A.; Ettouati, L.; Terreux, R.; Alame?, G.; Grenot, C.; Dumontet, C.; Di Pietro, A.; Paris, J.; Falson, P.
Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein
J. Med. Chem.
53
6720-6729
2010
Homo sapiens, Mus musculus
Collnot, E.M.; Baldes, C.; Schaefer, U.F.; Edgar, K.J.; Wempe, M.F.; Lehr, C.M.
Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access
Mol. Pharm.
7
642-651
2010
Homo sapiens
Yu, L.; Wu, W.K.; Li, Z.J.; Liu, Q.C.; Li, H.T.; Wu, Y.C.; Cho, C.H.
Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via inhibiting P-glycoprotein activity
Mol. Pharmacol.
75
1364-1373
2009
Homo sapiens
Nabekura, T.; Yamaki, T.; Hiroi, T.; Ueno, K.; Kitagawa, S.
Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals
Pharmacol. Res.
61
259-263
2010
Homo sapiens
Jutabha, P.; Wempe, M.F.; Anzai, N.; Otomo, J.; Kadota, T.; Endou, H.
Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux
Pharmacol. Res.
61
76-84
2010
Homo sapiens
Tachibana, T.; Kato, M.; Watanabe, T.; Mitsui, T.; Sugiyama, Y.
Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein
Xenobiotica
39
430-443
2009
Homo sapiens
Loo, T.W.; Bartlett, M.C.; Clarke, D.M.
Human P-glycoprotein is active when the two halves are clamped together in the closed conformation
Biochem. Biophys. Res. Commun.
395
436-440
2010
Homo sapiens
Palmeira, A.; Vasconcelos, M.H.; Paiva, A.; Fernandes, M.X.; Pinto, M.; Sousa, E.
Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones
Biochem. Pharmacol.
83
57-68
2012
Homo sapiens
Wittgen, H.G.; van den Heuvel, J.J.; Krieger, E.; Schaftenaar, G.; Russel, F.G.; Koenderink, J.B.
Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity
Biochem. Pharmacol.
84
366-373
2012
Homo sapiens
Eng, K.T.; Berdis, A.J.
A novel non-natural nucleoside that influences P-glycoprotein activity and mediates drug resistance
Biochemistry
49
1640-1648
2010
Homo sapiens
Ohnuma, S.; Chufan, E.; Nandigama, K.; Jenkins, L.M.; Durell, S.R.; Appella, E.; Sauna, Z.E.; Ambudkar, S.V.
Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5-fluorosulfonylbenzoyl 5-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites
Biochemistry
50
3724-3735
2011
Homo sapiens
Dezi, M.; Fribourg, P.F.; Di Cicco, A.; Arnaud, O.; Marco, S.; Falson, P.; Di Pietro, A.; Levy, D.
The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes
Biochim. Biophys. Acta
1798
2094-2101
2010
Homo sapiens
Nervi, P.; Li-Blatter, X.; Aanismaa, P.; Seelig, A.
P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity
Biochim. Biophys. Acta
1798
515-525
2010
Homo sapiens (P08183)
Loo, T.W.; Bartlett, M.C.; Detty, M.R.; Clarke, D.M.
The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together
J. Biol. Chem.
287
26806-26816
2012
Homo sapiens
Hall, M.D.; Brimacombe, K.R.; Varonka, M.S.; Pluchino, K.M.; Monda, J.K.; Li, J.; Walsh, M.J.; Boxer, M.B.; Warren, T.H.; Fales, H.M.; Gottesman, M.M.
Synthesis and structure-activity evaluation of isatin-beta-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein
J. Med. Chem.
54
5878-5889
2011
Homo sapiens
Luo, S.; Pal, D.; Shah, S.J.; Kwatra, D.; Paturi, K.D.; Mitra, A.K.
Effect of HEPES buffer on the uptake and transport of P-glycoprotein substrates and large neutral amino acids
Mol. Pharm.
7
412-420
2010
Homo sapiens
de Boussac, H.; Orban, T.I.; Varady, G.; Tihanyi, B.; Bacquet, C.; Brozik, A.; Varadi, A.; Sarkadi, B.; Aranyi, T.
Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters
Biochem. Biophys. Res. Commun.
426
172-176
2012
Homo sapiens
Wise, J.G.
Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites
Biochemistry
51
5125-5141
2012
Homo sapiens
Swartz, D.J.; Mok, L.; Botta, S.K.; Singh, A.; Altenberg, G.A.; Urbatsch, I.L.
Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance
Biosci. Rep.
34
e00116
2014
Homo sapiens
Zolnerciks, J.K.; Akkaya, B.G.; Snippe, M.; Chiba, P.; Seelig, A.; Linton, K.J.
The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle
FASEB J.
28
4335-4346
2014
Homo sapiens
Cole, S.P.
Multidrug resistance protein 1 (MRP1, ABCC1), a multitasking ATP-binding cassette (ABC) transporter
J. Biol. Chem.
289
30880-30888
2014
Homo sapiens
Chan, K.F.; Wong, I.L.; Kan, J.W.; Yan, C.S.; Chow, L.M.; Chan, T.H.
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation
J. Med. Chem.
55
1999-2014
2012
Homo sapiens
Ebert, S.P.; Wetzel, B.; Myette, R.L.; Conseil, G.; Cole, S.P.; Sawada, G.A.; Loo, T.W.; Bartlett, M.C.; Clarke, D.M.; Detty, M.R.
Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1)
J. Med. Chem.
55
4683-4699
2012
Homo sapiens
Meyer, M.R.; Orschiedt, T.; Maurer, H.H.
Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein
Toxicol. Lett.
217
137-142
2013
Homo sapiens
Esser, L.; Shukla, S.; Zhou, F.; Ambudkar, S.V.; Xia, D.
Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein
Acta Crystallogr. Sect. F
72
636-641
2016
Homo sapiens
Revalde, J.; Li, Y.; Hawkins, B.; Rosengren, R.; Paxton, J.
Heterocyclic cyclohexanone monocarbonyl analogs of curcumin can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance
Biochem. Pharmacol.
93
305-317
2015
Homo sapiens
Horsey, A.J.; Cox, M.H.; Sarwat, S.; Kerr, I.D.
The multidrug transporter ABCG2 still more questions than answers
Biochem. Soc. Trans.
44
824-830
2016
Homo sapiens (Q9UNQ0), Homo sapiens
Clay, A.T.; Lu, P.; Sharom, F.J.
Interaction of the P-glycoprotein multidrug transporter with sterols
Biochemistry
54
6586-6597
2015
Homo sapiens (P08183)
Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade
Cancer Lett.
370
153-164
2016
Homo sapiens, Homo sapiens (P08183), Homo sapiens (Q2M3G0), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0)
Arana, M.R.; Altenberg, G.
ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1
Curr. Med. Chem.
25
1-17
2017
Homo sapiens (Q2M3G0), Homo sapiens (Q8HXQ5), Homo sapiens (Q9UNQ0)
Murakami, M.; Ohnuma, S.; Fukuda, M.; Chufan, E.E.; Kudoh, K.; Kanehara, K.; Sugisawa, N.; Ishida, M.; Naitoh, T.; Shibata, H.; Iwabuchi, Y.; Ambudkar, S.V.; Unno, M.
Synthetic analogs of curcumin modulate the function of multidrug resistance-linked ATP-binding cassette transporter ABCG2
Drug Metab. Dispos.
45
1166-1177
2017
Homo sapiens (Q9UNQ0)
Beretta, G.L.; Cassinelli, G.; Pennati, M.; Zuco, V.; Gatti, L.
Overcoming ABC transporter-mediated multidrug resistance The dual role of tyrosine kinase inhibitors as multitargeting agents
Eur. J. Med. Chem.
142
271-289
2017
Homo sapiens (O15439), Homo sapiens (P08183), Homo sapiens (P33527), Homo sapiens (Q5T3U5), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0)
Pan, X.; Mei, H.; Qu, S.; Huang, S.; Sun, J.; Yang, L.; Chen, H.
Prediction and characterization of P-glycoprotein substrates potentially bound to different sites by emerging chemical pattern and hierarchical cluster analysis
Int. J. Pharm.
502
61-69
2016
Homo sapiens (P08183)
Wu, C.P.; Hsiao, S.H.; Murakami, M.; Lu, Y.J.; Li, Y.Q.; Huang, Y.H.; Hung, T.H.; Ambudkar, S.V.; Wu, Y.S.
alpha-Mangostin reverses multidrug resistance by attenuating the function of the multidrug resistance-linked ABCG2 transporter
Mol. Pharm.
14
2805-2814
2017
Homo sapiens (Q9UNQ0), Homo sapiens
Enright, E.F.; Govindarajan, K.; Darrer, R.; MacSharry, J.; Joyce, S.A.; Gahan, C.G.M.
Gut microbiota-mediated bile acid transformations alter the cellular response to multidrug resistant transporter substrates in vitro focus on P-glycoprotein
Mol. Pharm.
15
5711-5727
2018
Homo sapiens (P08183), Homo sapiens
Jackson, S.M.; Manolaridis, I.; Kowal, J.; Zechner, M.; Taylor, N.M.I.; Bause, M.; Bauer, S.; Bartholomaeus, R.; Bernhardt, G.; Koenig, B.; Buschauer, A.; Stahlberg, H.; Altmann, K.H.; Locher, K.P.
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2
Nat. Struct. Mol. Biol.
25
333-340
2018
Homo sapiens (Q9UNQ0), Homo sapiens
Taylor, N.M.I.; Manolaridis, I.; Jackson, S.M.; Kowal, J.; Stahlberg, H.; Locher, K.P.
Structure of the human multidrug transporter ABCG2
Nature
546
504-509
2017
Homo sapiens (Q9UNQ0), Homo sapiens
Guan, G.F.; Zhang, D.J.; Zheng, Y.; Wen, L.J.; Yu, D.J.; Lu, Y.Q.; Zhao, Y.
Significance of ATP-binding cassette transporter proteins in multidrug resistance of head and neck squamous cell carcinoma
Oncol. Lett.
10
631-636
2015
Homo sapiens (Q9UNQ0), Homo sapiens
Tocchetti, G.N.; Rigalli, J.P.; Arana, M.R.; Villanueva, S.S.M.; Mottino, A.D.
Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics
Toxicol. Appl. Pharmacol.
303
45-57
2016
Homo sapiens (Q92887), Rattus norvegicus (Q92887)
