3.4.22.38: cathepsin K
This is an abbreviated version!
For detailed information about cathepsin K, go to the full flat file.
Word Map on EC 3.4.22.38
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3.4.22.38
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resorption
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osteoporosis
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osteoclastogenesis
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rankl
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tartrate-resistant
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osteoblast
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collagen
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nfatc1
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rankl-induced
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multinucleated
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mmp-9
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c-fos
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fracture
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trabecular
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pi
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calcitonin
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osteocalcin
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osteoprotegerin
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osteolytic
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resorb
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m-csf
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collagenolytic
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bisphosphonates
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osteoclast-mediated
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trap-positive
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osteoclast-specific
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odanacatib
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oscar
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antiresorptive
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tracp
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lacuna
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ovariectomy-induced
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rankl-mediated
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dc-stamp
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bone-resorbing
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sclerostin
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osteoclast-related
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telopeptide
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osteoclast-like
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osteoclastogenic
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denosumab
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preosteoclasts
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teriparatide
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pharmacology
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anti-osteoclastogenic
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osteosclerosis
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anti-osteoporotic
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atp6v0d2
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medicine
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ranelate
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drug development
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deoxypyridinoline
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rankl-stimulated
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diagnostics
- 3.4.22.38
- resorption
- osteoporosis
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osteoclastogenesis
- rankl
-
tartrate-resistant
- osteoblast
- collagen
- nfatc1
-
rankl-induced
-
multinucleated
- mmp-9
- c-fos
-
fracture
-
trabecular
- pi
- calcitonin
- osteocalcin
- osteoprotegerin
-
osteolytic
-
resorb
- m-csf
-
collagenolytic
- bisphosphonates
-
osteoclast-mediated
-
trap-positive
-
osteoclast-specific
- odanacatib
- oscar
-
antiresorptive
- tracp
- lacuna
-
ovariectomy-induced
-
rankl-mediated
-
dc-stamp
-
bone-resorbing
-
sclerostin
-
osteoclast-related
-
telopeptide
-
osteoclast-like
-
osteoclastogenic
-
denosumab
-
preosteoclasts
-
teriparatide
- pharmacology
-
anti-osteoclastogenic
- osteosclerosis
-
anti-osteoporotic
- atp6v0d2
- medicine
-
ranelate
- drug development
-
deoxypyridinoline
-
rankl-stimulated
- diagnostics
Reaction
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg =
Synonyms
Cat K, Cat-K, cath K, cathepsin K, cathepsin O, Cathepsin O2, cathepsin-K, catK, Ctk, CTSK, Human osteoclast cathepsin K, More, OC-2 protein, rhCK
ECTree
3.4.22.38 cathepsin KAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.22.38 - cathepsin K
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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it is shown by fluorescence microscopy of plaque sections from using human carotid endarterectomy specimens that enzymatically active CatK (positive NIRF signal) localizes primarily in the vicinity of CatK-positive macrophages. Augmented NIRF signal (reflecting CatK activity) colocalizes with disrupted elastin fibers within the media underlying plaques
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biopsy sites, benign lesions, ductal carcinoma in situ, and invasive breast tumors of different stages. Neither epithelial nor stromal expression of CTSK is significantly associated with recurrence-free or overall survival
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left anterior descending coronary arteries with different degrees of atherosclerotic lesions, cathepsin K co-localizes with collagen type I in advanced atherosclerotic lesions especially at the plaque shoulders
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in the dermis, cathepsin K is expressed only under certain circumstances such as scarring or inflammation
cathepsin K, the chemo-attractant stromal-derived factor-1alpha and its C-X-C receptor type 4 are localized in therapy-resistant glioma stem-like cell (GSLC) niches in glioblastoma
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increased numbers of cathepsin K immunoreactive cells are found in left and right arcuate nucleus of schizophrenics
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in stroma of pulmonary adenocarcinomas, cathepsin K expression is restricted to the desmoplastic fibrous tissue of invasive components, no expression in bronchioloalveolar carcinoma
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immunostaining reveals strong catK expression in most primary melanomas and all cutaneous melanoma metastases. Melanocytic nevi also demonstrates catK expression, but it is less intense than in melanomas. Melanoma lines express both the pro- and the active form of catK
on the dental root side, expression pattern of cathepsin K, high expression level in the age of 4-5 weeks, when physiological root resorption occurs actively, co-expression with matrix metalloproteinase-9
additional information
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visceral, cathepsin K activity gradually increases in the process of adipocyte differentiation
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cathepsin K is increased by a suppressive L-thyroxine therapy and decreases with increasing age, overview
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from ankylosing spondylitis and degenerative disc disease patients, strong expression in the different regions of the spine. Cathepsin K-positive multinucleated cells are located at sites of bone destruction, overview
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articluar, from the metacarpophalangeal and healthy joints, immunohistochemic identification in different regions of the tissue from healthy and osteoarthritic animals, overview
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osteoarthritic and nonarthritic femoral condylar articular, and normal articular
at 3 h post-challenge with Aeromonas hydrophila, the cathepsins K expression is seen only in the heart
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cathepsin K transcripts are highly increased in the lungs after silica treatment compared to cathepsin S, L and B. The upregulation is specific for the fibrotic process
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qunatitative determination of enzyme content by immunohistochemistry, real time RT-PCR and western blotting
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qunatitative determination of enzyme content by immunohistochemistry, real time RT-PCR and western blotting
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cathepsin K is downregulated by the profibrotic growth factor TGF-beta1
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fibroblasts from patients with lung fibrosis contain more cathepsin K activity than those from normal lungs
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cathepsin K is downregulated by the profibrotic growth factor TGF-beta1
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primary lung fibroblasts derived from CTSK-/- mice show a decreased collagenolytic activity
osteoblast-like culture. Osteoblastic cathepsin K may contribute to collagenous matrix maintenance and recycling of improperly processed collagen I
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30355, 30361, 30365, 30366, 654410, 656456, 656457, 656472, 657251, 696654, 697010, 697257, 697775, 698935, 699557, 707899, 708260, 708689, 709855, 717159
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cathepsin K, colocalizes with tartrate-resistant acid phosphatase in osteoclast-resorptive compartments, supporting a role for cathepsin K in the extracellular processing of monomeric tartrate-resistant acid phosphatase in the resorption lacuna
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cathepsin K is one of the cysteine proteases expressed by osteoclasts, particularly at the cell surface adjacent to bone
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cathepsin K is secreted by osteoclasts, when they are resorbing bone
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from either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, mice, phenotypes, overview
localized on the surface of alveolar bone, expression pattern of cathepsin K, no co-expression with matrix metalloproteinase-9
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subcutaneous, the enzyme content is increased by 12fold during adipogenesis
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cathepsin K levels are not significantly increased in serum of patients with ankylosing spondylitis, 6.41 pg/ml in patients and 3.64 pg/ml in healthy controls, overview
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normal skin shows only low levels or no expression of cathepsin K. Dermal fibroblasts in surgical scars shows strong cytoplasmatic expression of cathepsin K. Expresson is most prominent in young scars and declines with time
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cultured neonatal primary fibroblasts show strong cathepsin K staining in the perinuclear endosomal compartment
In goldfish at 6 h post-infection, the cathepsin K is found all the tissues, except in the spleen
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stromal CTSK expression is significantly higher in invasive compared to in situ carcinomas
additional information
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not in cell lines: promyelotic leukemia (HL-60), lymphoblastic leukemia (MOLT-4), Burkitt's lymphoma, lung carcinoma (A549), melanoma G361
additional information
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cathepsin is also found to be strongly expressed in keloids and in dermatofibromas, but not in sclerotic areas of morphea
additional information
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high cathepsin K levels in men with differentiated thyroid cancer on suppressive L-thyroxine therapy, overview
additional information
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media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview
additional information
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media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview
